TAF5 cdna clone
TAF5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Description
TAF5: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. Belongs to the WD repeat TAF5 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10q24-q25.2
Cellular Component: actin cytoskeleton; intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; transcription factor TFIID complex
Molecular Function: histone acetyltransferase activity; protein binding; protein dimerization activity; transcription factor activity
Biological Process: chromatin modification; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation; transcription initiation from RNA polymerase II promoter
Research Articles on TAF5
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Product Notes
The TAF5 taf5 (Catalog #AAA1273977) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCGGCGC TGGCGGAGGA GCAGACGGAG GTGGCGGTCA AGCTAGAGCC TGAGGGACCG CCAACGCTGC TACCTCCGCA GGCGGGGGAC GGCGCAGGCG AGGGTAGCGG CGGCACTACC AACAACGGCC CCAACGGCGG CGGCGGGAAC GTTGCGGCGT CGTCGTCCAC TGGCGGGGAT GGCGGGACCC CCAAGCCCAC GGTGGCTGTC TCCGCCGCTG CCCCGGCGGG GGCGGCCCCG GTGCCCGCCG CTGCTCCGGA CGCCGGCGCT CCGCATGACC GACAGACTCT ACTGGCCGTG CTGCAGTTCC TACGGCAGAG CAAACTCCGC GAGGCCGAAG AGGCGCTGCG CCGTGAGGCC GGGCTGCTGG AGGAGGCAGT GGCGGGCTCC GGAGCCCCGG GAGAGGTGGA CAGCGCCGGC GCTGAGGTGA CCAGCGCGCT TCTCAGCCGG GTGACCGCCT CGGCCCCTGG CCCTGCGGCC CCCGACCCTC CGGGCACTGG CGCTTCGGGG GCCACGGTCG TCTCAGGTTC AGCCTCAGGT CCTGCGGCTC CGGGTAAAGT TGGAAGTGTT GCTGTGGAAG ACCAGCCAGA TGTCAGTGCC GTGTTGTCAG CCTACAACCA ACAAGGAGAT CCCACAATGT ATGAAGAATA CTATAGTGGA CTGAAACACT TCATTGAATG TTCCCTGGAC TGCCATCGGG CAGAGTTGTC CCAACTTTTT TATCCTCTGT TTGTGCACAT GTACTTGGAG CTAGTCTACA ATCAACATGA GAATGAAGCA AAGTCATTCT TTGAGAAGTT CCATGGAGAT CAGGAATGTT ATTACCAGGA TGACCTACGA GTATTATCTA GTCTTACCAA AAAGGAACAC ATGAAAGGGA ATGAGACCAT GTTGGATTTT CGAACAAGTA AATTTGTTCT GCGTATTTCC CGTGACTCGT ACCAACTCTT GAAGAGGCAT CTTCAGGAGA AACAGAACAA TCAGATATGG AACATAGTTC AGGAGCACCT CTACATTGAC ATCTTTGATG GGATGCCGCG TAGTAAGCAA CAGATAGATG CGATGGTGGG AAGTTTGGCA GGAGAGGCTA AACGAGAGGC AAACAAATCA AAGGTATTTT TTGGTTTATT AAAAGAACCA GAAATTGAGG TACCTTTGGA TGACGAGGAT GAAGAGGGAG AAAATGAAGA AGGAAAACCT AAAAAGAAGA AGCCTAAAAA AGATAGTATT GGATCCAAAA GCAAAAAACA AGATCCCAAT GCTCCACCTC AGAACAGAAT CCCTCTTCCT GAGTTGAAAG ATTCAGATAA GTTGGATAAG ATAATGAATA TGAAAGAAAC CACCAAACGA GTGCGCCTTG GGCCGGACTG CTTACCCTCC ATTTGTTTCT ATACATTTCT CAATGCTTAC CAGGGTCTCA CTGCAGTGGA TGTCACTGAT GATTCTAGTC TGATTGCTGG AGGTTTTGCA GATTCAACTG TCAGAGTGTG GTCGGTAACA CCCAAAAAGC TTCGTAGTGT CAAACAAGCA TCAGATCTTA GTCTTATAGA CAAAGAATCA GATGATGTCT TAGAAAGAAT CATGGATGAG AAAACAGCAA GTGAGTTGAA GATTTTGTAT GGTCACAGTG GGCCTGTCTA CGGAGCCAGC TTCAGTCCGG ATAGGAACTA TCTGCTTTCC TCTTCAGAGG ACGGAACTGT TAGATTGTGG AGCCTTCAAA CATTTACTTG TTTGGTGGGA TATAAAGGAC ACAACTATCC AGTATGGGAC ACACAATTTT CTCCATATGG ATATTATTTT GTGTCAGGGG GCCATGACCG AGTAGCTCGG CTCTGGGCTA CAGACCACTA TCAGCCTTTA AGAATATTTG CCGGCCATCT TGCTGATGTG AATTGTACCA GATTCCATCC AAATTCTAAT TATGTTGCTA CGGGCTCTGC AGACAGAACT GTGCGGCTCT GGGACGTCCT GAATGGTAAC TGTGTAAGGA TCTTCACTGG ACACAAGGGA CCAATTCATT CCTTGACATT TTCTCCCAAT GGGAGATTCC TGGCTACAGG AGCAACAGAT GGCAGAGTGC TTCTTTGGGA TATTGGACAT GGTTTGATGG TTGGAGAATT AAAAGGCCAC ACTGATACAG TCTGTTCACT TAGGTTTAGT AGAGATGGTG AAATTTTGGC ATCAGGTTCA ATGGATAATA CAGTTCGATT ATGGGATGCT ATCAAAGCCT TTGAAGATTT AGAGACCGAT GACTTTACTA CAGCCACTGG GCATATAAAT TTACCTGAGA ATTCACAGGA GTTATTGTTG GGAACATATA TGACCAAATC AACACCAGTT GTACACCTTC ATTTTACTCT AAGAAACCTG GTTCTAGCTG CAGGAGCTTA TAGTCCACAA TAA. It is sometimes possible for the material contained within the vial of "TAF5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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