SYNCRIP cdna clone
SYNCRIP cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
Uniprot Description
NSAP1: a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.
Protein type: Spliceosome; RNA splicing; RNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: membrane; nucleus; ribonucleoprotein complex
Molecular Function: protein binding; RNA binding
Biological Process: negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing; RNA splicing
Research Articles on SYNCRIP
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Product Notes
The SYNCRIP syncrip (Catalog #AAA1272622) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctacag aacatgttaa tggaaatggt actgaagagc ccatggatac tacttctgca gttatccatt cagaaaattt tcagacattg cttgatgctg gtttaccaca gaaagttgct gaaaaactag atgaaattta cgttgcaggg ctagttgcac atagtgattt agatgaaaga gctattgaag ctttaaaaga attcaatgaa gacggtgcat tggcagttct tcaacagttt aaagacagtg atctctctca tgttcagaac aaaagtgcct ttttatgtgg agtcatgaag acttacaggc agagagaaaa acaagggacc aaagtagcag attctagtaa aggaccagat gaggcaaaaa ttaaggcact cttggaaaga acaggctaca cacttgatgt gaccactgga cagaggaagt atggaggacc acctccagat tccgtttatt caggtcagca gccttctgtt ggcactgaga tatttgtggg aaagatccca agagatctat ttgaggatga acttgttcca ttatttgaga aagctggacc tatatgggat cttcgtctaa tgatggatcc actcactggt ctcaatagag gttatgcgtt tgtcactttt tgtacaaaag aagcagctca ggaggctgtt aaactgtata ataatcatga aattcgttct ggaaaacata ttggtgtctg catctcagtt gccaacaata ggctttttgt gggctctatt cctaagagta aaaccaagga acagattctt gaagaattta gcaaagtaac agagggtctt acagacgtca ttttatacca ccaaccggat gacaagaaaa aaaacagagg cttttgcttt cttgaatatg aagatcacaa aacagctgcc caggtaaaag tgctgtttgt acgcaacctt gccaatactg taacagaaga gattttagaa aaggcattta gtcagtttgg gaaactggaa cgagtgaaga agttaaaaga ttatgcgttc attcattttg atgagcgaga tggtgctgtc aaggctatgg aagaaatgaa tggcaaagac ttggagggag aaaatattga aattgttttt gccaagccac cagatcagaa aaggaaagaa agaaaagctc agaggcaagc agcaaaaaat caaatgtatg acgattacta ctattatggt ccacctcata tgccccctcc aacaagaggt cgagggcgtg gaggtagagg tggttatgga tatcctccag attattatgg atatgaagat tattatgatt attatggtta tgattaccat aactatcgtg gtggatatga agatccatac tatggttatg aagattttca agttggagct agaggaaggg gtggtagagg agcaaggggt gctgctccat ccagaggtcg tggggctgct cctccccgcg gtagagccgg ttattcacag agaggaggtc ctggatcagc aagaggcgtt cgaggtgcga gaggaggtgc ccaacaacaa agaggccgcg ggcagggaaa aggggtcgag gccggtcctg acctgttaca atga. It is sometimes possible for the material contained within the vial of "SYNCRIP, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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