SQSTM1 cdna clone
SQSTM1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Uniprot Description
SQSTM1: an adapter protein which binds ubiquitin, shuttling proteins to the proteasome. Co-localizes along with the E3 ubiquitin ligase, TRAF6, to aggregates from Alzheimer's disease brains but not in control brain. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Forms ternary complexes with PKCZ and Kv-beta2 or PKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with EBI3, LCK, RASA1, PKCZ , PKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MEK5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MEK5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: autophagic vacuole; cytoplasm; cytosol; inclusion body; nucleoplasm; PML body
Molecular Function: identical protein binding; protein binding; protein kinase binding; protein kinase C binding; receptor tyrosine kinase binding; SH2 domain binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: autophagy; endosome transport; macroautophagy; negative regulation of apoptosis; positive regulation of apoptosis; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; protein localization; regulation of I-kappaB kinase/NF-kappaB cascade; response to stress; ubiquitin-dependent protein catabolic process
Disease: Frontotemporal Dementia And/or Amyotrophic Lateral Sclerosis 3; Paget Disease Of Bone
Research Articles on SQSTM1
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Product Notes
The SQSTM1 sqstm1 (Catalog #AAA1266709) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccatgt cctacgtgaa ggatgacatc ttccgaatct acattaaaga gaaaaaagag tgccggcggg accaccgccc accgtgtgct caggaggcgc cccgcaacat ggtgcacccc aatgtgatct gcgatggctg caatgggcct gtggtaggaa cccgctacaa gtgcagcgtc tgcccagact acgacttgtg tagcgtctgc gagggaaagg gcttgcaccg ggggcacacc aagctcgcat tccccagccc cttcgggcac ctgtctgagg gcttctcgca cagccgctgg ctccggaagg tgaaacacgg acacttcggg tggccaggat gggaaatggg tccaccagga aactggagcc cacgtcctcc tcgtgcaggg gaggcccgcc ctggccccac ggcagaatca gcttctggtc catcggagga tccgagtgtg aatttcctga agaacgttgg ggagagtgtg gcagctgccc ttagccctct gggcattgaa gttgatatcg atgtggagca cggagggaaa agaagccgcc tgacccccgt ctctccagag agttccagca cagaggagaa gagcagctca cagccaagca gctgctgctc tgatcccagc aagccgggtg ggaatgttga gggcgccacg cagtctctgg cggagcagat gagaaagatc gccttggagt ccgaggggcg ccctgaggaa cagatggagt cggataactg ttcaggagga gatgatgact ggacccatct gtcttcaaaa gaagtggacc cgtctacagg tgaactccag tccctacaga tgccagaatc cgaagggcca agctctctgg acccctccca ggagggaccc acagggctga aggaagctgc cttgtaccca catctcccgc cagaggctga cccgcggctg attgagtccc tctcccagat gctgtccatg ggcttctctg atgaaggcgg ctggctcacc aggctcctgc agaccaagaa ctatgacatc ggagcggctc tggacaccat ccagtattca aagcatcccc cgccgttgtg a. It is sometimes possible for the material contained within the vial of "SQSTM1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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