SNX1 cdna clone
SNX1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
SNX1: May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cell-cell adherens junction; cytoplasm; early endosome membrane; endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; membrane; protein complex; retromer complex; vesicle
Molecular Function: epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: intracellular protein transport; receptor internalization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis
Research Articles on SNX1
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Product Notes
The SNX1 snx1 (Catalog #AAA1275849) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgtcgg gtggtggtgg ctgtagcgct tcggagagac tgcctccgcc cttccccggc ctggagccgg agtccgaggg ggcggccggg ggatcagaac ccgaggctgg ggacagcgac accgaggggg aggacatttt caccggcgcc gcggtggtca gtaaacatca gtctccaaag ataactacat cccttcttcc catcaacaat ggctccaaag aaaatgggat ccatgaagaa caagaccaag agccacagga tctctttgca gatgccacag tggagctatc cttggacagc acacaaaata atcagaagaa ggtgctagcc aaaacactca tttctcttcc tcctcaggaa gccacaaatt cttcgaagcc ccagccaacc tatgaggagc tagaggaaga agaacaggag gatcaatttg atttgacagt cggtataact gatcctgaga agatagggga tggtatgaat gcatatgtag cctacaaagt tacaacacag acaagcttac cattgttcag aagcaaacag tttgcagtaa aaagaagatt tagtgacttt ctgggtcttt atgagaagct ttccgagaag cactctcaga atggcttcat tgtccctcca cccccggaga agagcctcat agggatgaca aaagtgaaag ttgggaagga agattcttct tctgcagaat ttcttgaaaa acggagggcc gctttagaaa ggtaccttca gaggattgta aatcatccta ccatgttaca ggaccctgac gtcagagagt tcttggaaaa agaagagctg ccacgtgccg tgggtaccca gacattgagt ggtgctggtc tcctcaagat gttcaacaaa gccacagatg ccgtcagcaa aatgaccatc aagatgaatg aatcagacat ttggtttgag gagaagctcc aggaggtaga gtgtgaggag cagcgcttac ggaaactgca tgctgttgta gaaactctag tcaaccatag gaaagagcta gcgctgaaca cagcccagtt tgcaaagagt ctagccatgc ttgggagctc tgaggacaac acggcattgt cacgggcact ctcccagctg gctgaggtgg aagaaaaaat tgagcagctc caccaggaac aggccaacaa tgacttcttc ctccttgctg agctcctgag tgactacatt cgcctcctgg ccatagtccg cgctgccttc gaccagcgca tgaagacatg gcagcgctgg caggatgccc aagccacact gcagaagaag cgggaggccg aggctcggct gctgtgggcc aacaagcctg ataagctgca gcaggccaag gacgagatcc tcgagtggga gtctcgggtg actcaatatg aaagggactt cgagaggatt tcaacagtgg tccgaaaaga agtgatacgg tttgagaaag agaaatccaa ggacttcaag aaccacgtga tcaagtacct tgagacactc ctttactcac agcagcagct ggcaaagtac tgggaagcct tccttcctga ggcaaaggcc atctcctaa. It is sometimes possible for the material contained within the vial of "SNX1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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