SLC26A5 cdna clone
SLC26A5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Uniprot Description
SLC26A5: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site. Defects in SLC26A5 are the cause of deafness autosomal recessive type 61 (DFNB61). A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to plasma membrane
Molecular Function: anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity
Biological Process: bicarbonate transport; regulation of intracellular pH; regulation of membrane potential; sensory perception of sound
Research Articles on SLC26A5
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Product Notes
The SLC26A5 slc26a5 (Catalog #AAA1266268) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGATCATG CTGAAGAAAA TGAAATCCTT GCAGCAACCC AGAGGTACTA TGTGGAAAGG CCTATCTTTA GTCATCCGGT CCTCCAGGAA AGACTACACA CAAAGGACAA GGTTCCTGAT TCCATTGCGG ATAAGCTGAA ACAGGCATTC ACATGTACTC CTAAAAAAAT AAGAAATATC ATTTATATGT TCCTACCCAT AACTAAATGG CTGCCAGCAT ACAAATTCAA GGAATATGTG TTGGGTGACT TGGTCTCAGG CATAAGCACA GGGGTGCTTC AGCTTCCTCA AGGCTTAGCC TTTGCAATGC TGGCAGCTGT GCCTCCAATA TTTGGCCTGT ACTCTTCATT TTACCCTGTT ATCATGTATT GTTTTCTTGG AACCTCCAGA CACATATCCA TAGGTCCTTT TGCTGTTATT AGCCTGATGA TTGGTGGTGT AGCTGTTCGA TTAGTACCAG ATGATATAGT CATTCCAGGA GGAGTAAATG CAACCAATGG CACAGAGGCC AGAGATGCCT TGAGAGTGAA AGTCGCCATG TCTGTGACCT TACTTTCAGG AATCATTCAG TTTTGCCTAG GTGTCTGTAG GTTTGGATTT GTGGCCATAT ATCTCACAGA GCCTCTGGTC CGTGGGTTTA CCACCGCAGC AGCTGTGCAT GTCTTCACCT CCATGTTAAA ATATCTGTTT GGAGTTAAAA CAAAGCGGTA CAGTGGAATC TTTTCCGTGG TGTATAGTAC AGTTGCTGTG TTGCAGAATG TTAAAAACCT CAACGTGTGT TCCCTAGGCG TCGGGCTGAT GGTTTTTGGT TTGCTGTTGG GTGGCAAGGA GTTTAATGAG AGATTTAAAG AGAAATTGCC GGCGCCTATT CCTTTAGAGT TCTTTGCGGT CGTAATGGGA ACTGGCATTT CAGCTGGGTT TAACTTGAAA GAATCATACA ATGTGGATGT CGTTGGAACA CTTCCTCTAG GGCTGCTACC TCCAGCCAAT CCGGACACCA GCCTCTTCCA CCTTGTGTAC GTAGATGCCA TTGCCATAGC CATCGTTGGA TTTTCAGTGA CCATCTCCAT GGCCAAGACC TTAGCAAATA AACATGGCTA CCAGGTTGAC GGCAATCAGG AGCTCATTGC CCTGGGACTG TGCAATTCCA TTGGCTCACT CTTCCAGACC TTTTCAATTT CATGCTCCTT GTCTCGAAGC CTTGTTCAGG AGGGAACCGG TGGGAAGACA CAGCTTGCAG GTTGTTTGGC CTCATTAATG ATTCTGCTGG TCATATTAGC AACTGGATTC CTCTTTGAAT CATTGCCCCA GACCATCTGG CTTACCACTT TTGTGTCCTC CTTGTTCCTG GGATTGGACT ATGGTTTGAT CACTGCTGTG ATCATTGCTC TGCTGACTGT GATTTACAGA ACACAGAGGT GA. It is sometimes possible for the material contained within the vial of "SLC26A5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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