SLC22A1 cdna clone
SLC22A1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
Uniprot Description
SLC22A1: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: acetylcholine transmembrane transporter activity; dopamine transmembrane transporter activity; norepinephrine transmembrane transporter activity; organic cation transmembrane transporter activity; protein binding; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity
Biological Process: dopamine transport; multidrug transport; neurotransmitter transport; norepinephrine transport; organic cation transport
Research Articles on SLC22A1
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Product Notes
The SLC22A1 slc22a1 (Catalog #AAA1270898) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcccaccg tggatgacat tctggagcag gttggggagt ctggctggtt ccagaagcaa gccttcctca tcttatgcct gctgtcggct gcctttgcgc ccatctgtgt gggcatcgtc ttcctgggtt tcacacctga ccaccactgc cagagtcctg gggtggctga gctgagccag cgctgtggct ggagccctgc ggaggagctg aactatacag tgccaggcct ggggcccgcg ggcgaggcct tccttggcca gtgcaggcgc tatgaagtgg actggaacca gagcgccctc agctgtgtag accccctggc tagcctggcc accaacagga gccacctgcc gctgggtccc tgccaggatg gctgggtgta tgacacgccc ggctcttcca tcgtcactga gttcaacctg gtgtgtgctg actcctggaa gctggacctc tttcagtcct gtttgaatgc gggcttcttc tttggctctc tcggtgttgg ctactttgca gacaggtttg gccgtaagct gtgtctcctg ggaactgtgc tggtcaacgc ggtgtcgggc gtgctcatgg ccttctcgcc caactacatg tccatgctgc tcttccgcct gctgcagggc ctggtcagca agggcaactg gatggctggc tacaccctaa tcacagaatt tgttggctcg ggctccagaa gaacggtggc gatcatgtac cagatggcct tcacggtggg gctggtggcg cttaccgggc tggcctacgc cctgcctcac tggcgctggc tgcagctggc agtctccctg cccaccttcc tcttcctgct ctactactgg tgtgtgccgg agtcccctcg gtggctgtta tcacaaaaaa gaaacactga agcaataaag ataatggacc acatcgctca aaagaatggg aagttgcctc ctgctgattt aaagatgctt tccctcgaag aggatgtcac cgaaaagctg agcccttcat ttgcagacct gttccgcacg ccgcgcctga ggaagcgcac cttcatcctg atgtacctgt ggttcacgga ctctgtgctc tatcaggggc tcatcctgca catgggcgcc accagcggga acctctacct ggatttcctt tactccgctc tggtcgaaat cccgggggcc ttcatagccc tcatcaccat tgaccgcgtg ggccgcatct accccatggc catgtcaaat ttgttggcgg gggcagcctg cctcgtcatg atttttatct cacctgacct gcactggtta aacatcataa tcatgtgtgt tggccgaatg ggaatcacca ttgcaataca aatgatctgc ctggtgaatg ctgagctgta ccccacattc gtcaggaacc tcggagtgat ggtgtgttcc tccctgtgtg acataggtgg gataatcacc cccttcatag tcttcaggct gagggaggtc tggcaagcct tgcccctcat tttgtttgcg gtgttgggcc tgcttgccgc gggagtgacg ctacttcttc cagagaccaa gggggtcgct ttgccagaga ccatgaagga cgccgagaac cttgggagaa aagcaaagcc caaagaaaac acgatttacc ttaaggtcca aacctcagaa ccctcgggca cctga. It is sometimes possible for the material contained within the vial of "SLC22A1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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