Sequence
atgaagcggcgtttggatgaccaggagtcaccggtgtatgcagcccagcagcgtcggatccctggcagcacagaggcttttcctcaccagcaccgggtgcttgcccctgcccctcctgtgtatgaagcagtgtctgagaccatgcagtcagctacgggaattcagtactctgtaacacccagctaccaggtttcagccatgccacagagctccggcagtcatgggcccgctatagcagcagttcatagcagccatcatcacccaacagcggtgcagccccacggaggccaggtggtccagagtcatgctcatccagccccaccagttgcaccagtgcagggacagcagcaatttcagaggctgaaggtggtattcagctctttttcttgggtcaaaaaatttatctttagcaggaaatactggttgcagcttgttggttgtggtggtacaacttctaacctgagatactag
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
Molecular Weight
145,175 Da
NCBI Official Full Name
Homo sapiens SIN3 homolog A, transcription regulator (yeast), mRNA
NCBI Official Synonym Full Names
SIN3 transcription regulator family member A
NCBI Official Symbol
SIN3A
NCBI Official Synonym Symbols
WITKOS
NCBI Protein Information
paired amphipathic helix protein Sin3a
UniProt Protein Name
Paired amphipathic helix protein Sin3a
UniProt Entry Name
SIN3A_HUMAN
NCBI Description
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Uniprot Description
SIN3A: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase.
Protein type: Nucleolus; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: cytoplasm; intercellular bridge; nucleoplasm; nucleus; Sin3 complex
Molecular Function: histone deacetylase activity; protein binding; protein deacetylase activity
Biological Process: activation of innate immune response; cellular lipid metabolic process; histone deacetylation; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of chromatin silencing; positive regulation of defense response to virus by host; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation
Research Articles on SIN3A
Similar Products
Product Notes
The SIN3A sin3a (Catalog #
AAA1274897) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagcggc gtttggatga ccaggagtca ccggtgtatg cagcccagca gcgtcggatc cctggcagca cagaggcttt tcctcaccag caccgggtgc ttgcccctgc ccctcctgtg tatgaagcag tgtctgagac catgcagtca gctacgggaa ttcagtactc tgtaacaccc agctaccagg tttcagccat gccacagagc tccggcagtc atgggcccgc tatagcagca gttcatagca gccatcatca cccaacagcg gtgcagcccc acggaggcca ggtggtccag agtcatgctc atccagcccc accagttgca ccagtgcagg gacagcagca atttcagagg ctgaaggtgg tattcagctc tttttcttgg gtcaaaaaat ttatctttag caggaaatac tggttgcagc ttgttggttg tggtggtaca acttctaacc tgagatacta g.
It is sometimes possible for the material contained within the vial of
"SIN3A, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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