NCBI Description
This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. [provided by RefSeq, Jul 2016]
Uniprot Description
7B2: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Belongs to the 7B2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 15q13-q14
Cellular Component: secretory granule
Molecular Function: enzyme inhibitor activity; GTP binding; protein binding; unfolded protein binding
Biological Process: intracellular protein transport; peptide hormone processing; regulation of hormone secretion
Product Notes
The SCG5 scg5 (Catalog #
AAA1268745) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtctcca ggatggtctc taccatgcta tctggcctac tgttttggct ggcatctgga tggactccag catttgctta cagcccccgg acccctgacc gggtctcaga agcagatatc cagaggctgc ttcatggtgt tatggagcaa ttgggcattg ccaggccccg agtggaatat ccagctcacc aggccatgaa tcttgtgggc ccccagagca ttgaaggtgg agctcatgaa ggacttcagc atttgggtcc ttttggcaac atccccaaca tcgtggcaga gttgactgga gacaacattc ctaaggactt tagtgaggat caggggtacc cagaccctcc aaatccctgt cctgttggaa aaacagcaga tgatggatgt ctagaaaaca cccctgacac tgcagagttc agtcgagagt tccagttgca ccagcatctc tctgatccgg aacatgacta tccaggcttg ggcaagtgga acaagaaact cctttacgag aagatgaagg gaggagagag acgaaagcgg aggagtgtca atccatatct acaaggacag agactggata atgttgttgc aaagaagtct gtcccccatt tttcagatga ggataaggat ccagagtaa.
It is sometimes possible for the material contained within the vial of
"SCG5, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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aspect of this datasheet at
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