RPS6 cdna clone

RPS6

Cat. Num. AAA200551

• Gene Names: RPS6; S6
• Synonyms: RPS6; S6; RPS6 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGAAGCTGA ACATCTCCTT CCCAGCCACT GGCTGCCAGA AACTCATTGA AGTGGACGAT GAACGCAAAC TTCGTACTTT CTATGAGAAG CGTATGGCCA CAGAAGTTGC TGCTGACGCT CTGGGTGAAG AATGGAAGGG TTATGTGGTC CGAATCAGTG GTGGGAACGA CAAACAAGGT TTCCCCATGA AGCAGGGTGT CTTGACCCAT GGCCGTGTCC GCCTGCTACT GAGTAAGGGG CATTCCTGTT ACAGACCAAG GAGAACTGGA GAAAGAAAGA GAAAATCAGT TCGTGGTTGC ATTGTGGATG CAAATCTGAG CGTTCTCAAC TTGGTTATTG TAAAAAAAGG AGAGAAGGAT ATTCCTGGAC TGACTGATAC TACAGTGCCT CGCCGCCTGG GCCCCAAAAG AGCTAGCAGA ATCCGCAAAC TTTTCAATCT CTCTAAAGAA GATGATGTCC GCCAGTATGT TGTAAGAAAG CCCTTAAATA AAGAAGGTAA GAAACCTAGG ACCAAAGCAC CCAAGATTCA GCGTCTTGTT ACTCCACGTG TCCTGCAGCA CAAACGGCGG CGTATTGCTC TGAAGAAGCA GCGTACCAAG AAAAATAAAG AAGAGGCTGC AGAATATGCT AAACTTTTGG CCAAGAGAAT GAAGGAGGCT AAGGAGAAGC GCCAGGAACA AATTGCGAAG AGACGCAGAC TTTCCTCTCT GCGAGCTTCT ACTTCTAAGT CTGAATCCAG TCAGAAATAA; ; Translation Sequence: MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS TSKSESSQK
• Sequence Length: 249

• Species: Human
• Chromosome Location: 9p21
• OMIM Reference Number: 180460
• cDNA Size: 750bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for RPS6 cdna clone

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Product Categories/Family for RPS6 cdna clone

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 17158044
• NCBI GeneID: 6194
• NCBI Accession #: NP_001001.2
• NCBI GenBank Nucleotide #: NM_001010.2
• UniProt Accession #: P62753
• NCBI Official Full Name: 40S ribosomal protein S6
• NCBI Official Synonym Full Names: ribosomal protein S6
• NCBI Official Symbol: RPS6
• NCBI Official Synonym Symbols: S6
• NCBI Protein Information: 40S ribosomal protein S6
• UniProt Protein Name: 40S ribosomal protein S6
• Protein Family: 30S ribosomal protein
• UniProt Gene Name: RPS6
• UniProt Entry Name: RS6_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

S6: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family.

Protein type: Translation

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: polysome; small ribosomal subunit; membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; nucleolus; nucleus; ribonucleoprotein complex; cytosol

Molecular Function: protein binding; structural constituent of ribosome; protein kinase binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; erythrocyte development; TOR signaling pathway; translation; viral reproduction; positive regulation of apoptosis; T cell differentiation in the thymus; gastrulation; translational termination; viral infectious cycle; glucose homeostasis; oogenesis stage; T cell proliferation during immune response; translational initiation; ribosomal small subunit assembly and maintenance; viral transcription; activated T cell apoptosis; placenta development; mitosis; mitotic cell cycle checkpoint; ribosomal small subunit biogenesis and assembly; translational elongation; cellular protein metabolic process; mRNA catabolic process, nonsense-mediated decay; insulin receptor signaling pathway; gene expression; rRNA processing; G1/S transition of mitotic cell cycle; negative regulation of apoptosis