RPS3 cdna clone
RPS3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Description
RPS3: a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer.
Protein type: EC 4.2.99.18; Ribosomal; RNA-binding; Apoptosis; Translation
Chromosomal Location of Human Ortholog: 11q13.3-q13.5
Cellular Component: cytoplasm; cytosol; extracellular matrix; focal adhesion; membrane; mitochondrial inner membrane; mitochondrial matrix; nucleolus; nucleoplasm; nucleus; plasma membrane; polysome; ribonucleoprotein complex; ribosome
Molecular Function: damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; kinase binding; microtubule binding; mRNA binding; oxidized purine DNA binding; oxidized pyrimidine DNA binding; protein binding; protein kinase A binding; protein kinase binding; RNA binding; structural constituent of ribosome; SUMO binding; transcription factor binding; tubulin binding
Biological Process: chromosome segregation; DNA damage response, detection of DNA damage; mRNA catabolic process, nonsense-mediated decay; negative regulation of DNA repair; negative regulation of protein ubiquitination; negative regulation of translation; positive regulation of DNA repair; positive regulation of endodeoxyribonuclease activity; positive regulation of JNK activity; positive regulation of microtubule polymerization; regulation of apoptosis; response to DNA damage stimulus; response to oxidative stress; rRNA processing; spindle assembly; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Research Articles on RPS3
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Product Notes
The RPS3 rps3 (Catalog #AAA1277584) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcagtgc aaatatccaa gaagaggaag tttgtcgctg atggcatctt caaagctgaa ctgaatgagt ttcttactcg ggagctggct gaagatggct actctggagt tgaggtgcga gttacaccaa ccaggacaga aatcattatc ttagccacca gaacacagaa tgttcttggt gagaagggcc ggcggattcg ggaactgact gctgtagttc agaagaggtt tggctttcca gagggcagtg tagagcttta tgctgaaaag gtggccacta gaggtctgtg tgccattgcc caggcagagt ctctgcgtta caaactccta ggagggcttg ctgtgcggag ggcctgctat ggtgtgctgc ggttcatcat ggagagtggg gccaaaggct gcgaggttgt ggtgtctggg aaactccgag gacagagggc taaatccatg aagtttgtgg atggcctgat gatccacagc ggagaccctg ttaactacta cgttgacact gctgtgcgcc acgtgttgct cagacagggt gtgctgggca tcaaggtgaa gatcatgctg ccctgggacc caactggtaa gattggccct aagaagcccc tgcctgacca cgtgagcatt gtggaaccca aagatgagat actgcccacc acccccatct cagaacagaa gggtgggaag ccagagccgc ctgccatgcc ccagccagtc cccacagcat aa. It is sometimes possible for the material contained within the vial of "RPS3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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