RNF40 cdna clone
RNF40 cDNA Clone
Synonyms
RNF40; RNF40 cDNA Clone; RNF40 cdna clone
Sequence
atgtctgggccaggcaacaaacgcgccgccggcgacgggggctcagggcccccggaaaagaagctgagtcgtgaggagaagaccaccacgactcttatcgagcccattcgtcttggaggcatctcttccacggaggagatggacctgaaggtactacagttcaagaacaagaaactggcagagcggctggaacaacggcaggcttgtgaagatgaactccgagaacgaattgagaagttggagaagcggcaggccacagatgatgccacactcctcatcgtcaatcgctactgggcccagctggatgaaactgtggaagcccttctccgatgccatgagagccagggggagctgtcttcagcgcctgaggcacctgggacccaggaggggccaacatgtgatgggactcctctcccagagccggggacatcagagctgagagaccccttgctgatgcagctgcggccccctctcagtgagccggccttggcttttgtggtggcactgggtgccagcagcagtgaggaggtggagctggagctgcaaggccgaatggagttctccaaggcagctgtgtctcgtgtggtagaggcctcagaccgcctacagcgccgggtggaggaactctgtcagcgagtgtacagccgaggggacagtgagcccctcagtgaggcggctcaggcacacacccgagagctgggccgtgagaaccggcgactgcaggacttggccactcagctgcaggagaaacaccaccgcatctcattggagtactccgagctccaggataaagtgacatcggcagagaccaaggtgctggagatggagacaacagtggaggacttgcagtgggacatcgagaagctgcggaagcgagagcaaaagctcaataagcacctggcagaggccttagagcagcttaactctggctactatgtatctgggagctcctcaggcttccaggggggccagatcacactcagcatgcagaagtttgagatgctgaatgcagagttagaggaaaaccaggaactggccaacagccgtatggcagagctggagaaactgcaggccgaacttcagggggctgtgcggaccaatgagcgcctcaaggtggccctgcggagccttcctgaggaggtagtgcgggagacgggggagtaccgcatgctgcaggcccaattctcactgctctacaacgagtctctgcaagtgaagacccagctagacgaggctcggggcctgctgctggccacaaagaactcccacctgcgacacatcgagcacatggagagcgacgagctggggctgcagaagaagctacgcacagaggtcattcagctggaggacacgctggcccaggtacgcaaggagtatgagatgctgcgcatcgagtttgagcagaatctggcggccaacgagcaggcggggcccatcaaccgtgagatgcgccacctgattagtagtcttcaaaaccacaaccaccagctaaaaggggacgcccagcgatacaagcggaagcttcgagaagtacaagctgagattggcaagctccgggcccaggccagtggctctgcccactccacccccaacctgggccacccagaggattctggcgtcagtgccccagccccagggaaagaggagggtgggccaggccctgtcagtacccccgacaacagaaaggagatggctccagtgcctggcaccaccactactaccacttcagtgaagaaggaggagctggtcccctctgaagaggacttccagggtataacccctggggcccagggcccttcctcccggggccgagaacctgaggccaggcccaagcgggagcttcgggaacgggaaggtcccagcctaggacctccacctgtagcctccgctctctcaagggctgatcgggagaaggccaaggtggaagaaaccaagcggaaggaatcagaactcctcaagggtctccgagcagagctcaagaaggcccaggagagccagaaggagatgaaactgctgctggatatgtacaagtcagcgcccaaggagcagcgggataaggtgcagctcatggcagcggaacgcaaggctaaggccgaggttgatgagctgcggagccgcatccgggaattggaggagagggatcgaagggagagcaagaagatcgcggatgaggatgccctgcggcgcattcggcaggcagaggagcagatagaacacctgcagcgcaagctgggtgccaccaagcaggaggaggaggctctgctctcagagatggatgtgacaggtcaggcttttgaggacatgcaggaacagaacgggcggctgctacagcagttgcgggaaaaggatgatgccaactttaagctaatgtcagagcggatcaaggccaaccagattcacaagctgctgcgggaggagaaggatgagttgggcgagcaggtccttggcctcaagtcccaggtggatgcccagctgctgactgtgcagaagctggaggagaaggagcgagccttgcagggcagcctcgggggtgtggagaaggagctgacgctgcgcagccaagccctggagctcaacaagcggaaggctgtagaagccgcccagctggccgaggacctgaaggtgcagctggagcacgtgcagactcggctgcgggagatccagccctgcctggcagagagccgggctgctcgtgagaaagagagcttcaacctcaagagggctcaggaggacatctcacggctgcggcgcaagctggaaaagcagaggaaggtggaggtctacgcagatgccgacgaaatcctccaggaggagatcaaggagtacaaggcgcggttgacctgcccctgctgtaacacccgcaagaaggatgcagtccttaccaagtgcttccacgttttctgcttcgagtgcgtgcggggccgctatgaggcccgccagaggaagtgccccaagtgcaacgcggcctttggtgcccacgacttccatcgtatctacatcagctga
Sequence Length
3006
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
102,046 Da
NCBI Official Full Name
Homo sapiens ring finger protein 40, mRNA
UniProt Protein Name
E3 ubiquitin-protein ligase BRE1B
Protein Family
UniProt Gene Name
RNF40
UniProt Synonym Gene Names
BRE1B; KIAA0661; BRE1-B; RBP95
UniProt Entry Name
BRE1B_HUMAN
Uniprot Description
RNF40: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. Belongs to the BRE1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16p11.2-p11.1
Cellular Component: membrane; neuron projection; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function: mRNA 3'-UTR binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: histone H2B ubiquitination; histone monoubiquitination; regulation of mitotic cell cycle; ubiquitin-dependent protein catabolic process
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Product Notes
The RNF40 rnf40 (Catalog #AAA1265926) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctgggc caggcaacaa acgcgccgcc ggcgacgggg gctcagggcc cccggaaaag aagctgagtc gtgaggagaa gaccaccacg actcttatcg agcccattcg tcttggaggc atctcttcca cggaggagat ggacctgaag gtactacagt tcaagaacaa gaaactggca gagcggctgg aacaacggca ggcttgtgaa gatgaactcc gagaacgaat tgagaagttg gagaagcggc aggccacaga tgatgccaca ctcctcatcg tcaatcgcta ctgggcccag ctggatgaaa ctgtggaagc ccttctccga tgccatgaga gccaggggga gctgtcttca gcgcctgagg cacctgggac ccaggagggg ccaacatgtg atgggactcc tctcccagag ccggggacat cagagctgag agaccccttg ctgatgcagc tgcggccccc tctcagtgag ccggccttgg cttttgtggt ggcactgggt gccagcagca gtgaggaggt ggagctggag ctgcaaggcc gaatggagtt ctccaaggca gctgtgtctc gtgtggtaga ggcctcagac cgcctacagc gccgggtgga ggaactctgt cagcgagtgt acagccgagg ggacagtgag cccctcagtg aggcggctca ggcacacacc cgagagctgg gccgtgagaa ccggcgactg caggacttgg ccactcagct gcaggagaaa caccaccgca tctcattgga gtactccgag ctccaggata aagtgacatc ggcagagacc aaggtgctgg agatggagac aacagtggag gacttgcagt gggacatcga gaagctgcgg aagcgagagc aaaagctcaa taagcacctg gcagaggcct tagagcagct taactctggc tactatgtat ctgggagctc ctcaggcttc caggggggcc agatcacact cagcatgcag aagtttgaga tgctgaatgc agagttagag gaaaaccagg aactggccaa cagccgtatg gcagagctgg agaaactgca ggccgaactt cagggggctg tgcggaccaa tgagcgcctc aaggtggccc tgcggagcct tcctgaggag gtagtgcggg agacggggga gtaccgcatg ctgcaggccc aattctcact gctctacaac gagtctctgc aagtgaagac ccagctagac gaggctcggg gcctgctgct ggccacaaag aactcccacc tgcgacacat cgagcacatg gagagcgacg agctggggct gcagaagaag ctacgcacag aggtcattca gctggaggac acgctggccc aggtacgcaa ggagtatgag atgctgcgca tcgagtttga gcagaatctg gcggccaacg agcaggcggg gcccatcaac cgtgagatgc gccacctgat tagtagtctt caaaaccaca accaccagct aaaaggggac gcccagcgat acaagcggaa gcttcgagaa gtacaagctg agattggcaa gctccgggcc caggccagtg gctctgccca ctccaccccc aacctgggcc acccagagga ttctggcgtc agtgccccag ccccagggaa agaggagggt gggccaggcc ctgtcagtac ccccgacaac agaaaggaga tggctccagt gcctggcacc accactacta ccacttcagt gaagaaggag gagctggtcc cctctgaaga ggacttccag ggtataaccc ctggggccca gggcccttcc tcccggggcc gagaacctga ggccaggccc aagcgggagc ttcgggaacg ggaaggtccc agcctaggac ctccacctgt agcctccgct ctctcaaggg ctgatcggga gaaggccaag gtggaagaaa ccaagcggaa ggaatcagaa ctcctcaagg gtctccgagc agagctcaag aaggcccagg agagccagaa ggagatgaaa ctgctgctgg atatgtacaa gtcagcgccc aaggagcagc gggataaggt gcagctcatg gcagcggaac gcaaggctaa ggccgaggtt gatgagctgc ggagccgcat ccgggaattg gaggagaggg atcgaaggga gagcaagaag atcgcggatg aggatgccct gcggcgcatt cggcaggcag aggagcagat agaacacctg cagcgcaagc tgggtgccac caagcaggag gaggaggctc tgctctcaga gatggatgtg acaggtcagg cttttgagga catgcaggaa cagaacgggc ggctgctaca gcagttgcgg gaaaaggatg atgccaactt taagctaatg tcagagcgga tcaaggccaa ccagattcac aagctgctgc gggaggagaa ggatgagttg ggcgagcagg tccttggcct caagtcccag gtggatgccc agctgctgac tgtgcagaag ctggaggaga aggagcgagc cttgcagggc agcctcgggg gtgtggagaa ggagctgacg ctgcgcagcc aagccctgga gctcaacaag cggaaggctg tagaagccgc ccagctggcc gaggacctga aggtgcagct ggagcacgtg cagactcggc tgcgggagat ccagccctgc ctggcagaga gccgggctgc tcgtgagaaa gagagcttca acctcaagag ggctcaggag gacatctcac ggctgcggcg caagctggaa aagcagagga aggtggaggt ctacgcagat gccgacgaaa tcctccagga ggagatcaag gagtacaagg cgcggttgac ctgcccctgc tgtaacaccc gcaagaagga tgcagtcctt accaagtgct tccacgtttt ctgcttcgag tgcgtgcggg gccgctatga ggcccgccag aggaagtgcc ccaagtgcaa cgcggccttt ggtgcccacg acttccatcg tatctacatc agctga. It is sometimes possible for the material contained within the vial of "RNF40, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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