RNF212 cdna clone
RNF212 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Uniprot Description
RNF212: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. 6 human isoforms produced by alternative splicing.
Protein type: Ligase; EC 6.3.2.-; SUMO ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: synaptonemal complex
Biological Process: chiasma formation; meiotic gene conversion; meiotic recombination
Disease: Recombination Rate Quantitative Trait Locus 1
Research Articles on RNF212
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Product Notes
The RNF212 rnf212 (Catalog #AAA1272089) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCAACT GGGTGTTCTG TAATCGCTGC TTCCAGCCGC CCCACAGGAC GTCGTGCTTC AGCCTCACCA ACTGCGGGCA CGTGTACTGC GACGCCTGCC TCGGCAAAGG TAAAAAGAAT GAATGCTTGA TTTGTAAAGC TCCTTGTCGT ACAGTTTTGC TTTCAAAGCA TACCGACGCA GATATCCAGG CATTCTTCAT GAGCATAGAC AGTCTGTGTA AGAAGTACTC CAGGGAAACC TCCCAGATTT TAGAATTTCA AGAAAAACAC AGGAAGAGAT TGTTAGCCTT CTATAGAGAA AAGATTTCTA GGTTGGAAGA ATCCCTTAGG AAGTCAGTGC TGCAGATAGA ACAACTACAA AGTATGAGAT CATCACAACA AACAGCTTTC AGCACAATAA AAAGTTCAGT TTCAACAAAA CCACACGGAT GCCTGCTGCA ACCTCACTCA TCAGCACCCG ACAGACTGGA GTCGATGGAA GTTGATCTCT CTCCTTCTCC GATTAGAAAA TCTGAGATAG CAGCCGGCCC TGCGAGAATC TCCATGATTA GTCCACCTCA AGATGGACGA ATGGGTTGA. It is sometimes possible for the material contained within the vial of "RNF212, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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