RNF139 cdna clone
RNF139 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Uniprot Description
RNF139: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. Defects in RNF139 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1) with FHIT. RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained and expressed. Sporadic cases of renal carcinoma, where an acquired mutation in RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified.
Protein type: Ubiquitin conjugating system; Membrane protein, integral; EC 6.3.2.19; Ubiquitin ligase; Membrane protein, multi-pass; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: endoplasmic reticulum; integral to membrane
Molecular Function: ligase activity; protease binding; protein binding; receptor activity; small conjugating protein ligase activity; ubiquitin-protein ligase activity
Biological Process: negative regulation of cell proliferation; negative regulation of translation; proteasomal ubiquitin-dependent protein catabolic process; protein destabilization; protein polyubiquitination; protein ubiquitination; regulation of protein ubiquitination
Disease: Renal Cell Carcinoma, Nonpapillary
Research Articles on RNF139
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Product Notes
The RNF139 rnf139 (Catalog #AAA1273746) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggccg tggggccccc gcagcagcag gtgcggatgg cccatcagca ggtctgggcg gcgctcgaag tggcgctccg ggtgccctgc ctttacatca tcgacgccat cttcaactcc tacccggatt ccagccaaag ccggttctgc atcgtgctcc agatcttcct ccggctcttt ggtgtatttg catccagtat tgttctgatc ttgtcacaac gatcactttt caagttttac acgtacagct cagcctttct gttagctgca acttcagtgt tggtgaatta ttatgcttct ttgcacattg acttctatgg tgcctacaac acgtcagctt ttggaattga gctgcttcct cgaaaaggtc cctcgctgtg gatggcactt atcgttctac agctaacatt tggaattgga tacgttacac tactccagat tcattccatc tattcacaat taattatttt ggatctcttg gttcctgtaa taggcttaat cacagagcta ccattacaca tcagagagac tttactgttt acttcttcct tgattctcac attaaataca gtgtttgtcc tggcagtgaa actgaagtgg ttttattatt ccacacgata tgtttatctt ttggtgaggc acatgtatcg aatttatgga ttacagttat tgatggagga cacatggaag aggattcgtt tcccagacat actacgagtc ttttggctaa caagagttac agctcaggct acagtgttaa tgtacatctt aaggatggca aatgaaactg attccttctt tatttcttgg gatgattttt gggacctcat ttgcaatctt ataattagtg ggtgcgattc tacactaact gtactgggca tgagtgctgt aatttcctca gtagcccatt atttggggct tggaatattg gcctttattg gatcaactga ggaagatgac aggcgtcttg gctttgttgc acctgtttta ttttttattt tggctcttca gactgggtta agtgggctaa gaccagaaga gagacttatt cgcttaagta gaaacatgtg ccttttatta actgcagtcc tgcattttat ccatggaatg acagaccctg tattaatgtc tctcagtgcc tctcatgtgt catcttttcg tagacatttt cctgtgctgt ttgtctctgc ttgcctgttt attcttcctg tcttactcag ttatgttctt tggcatcact atgcactaaa tacatggttg tttgcagtta cagcattttg tgtggaactg tgcttaaaag taattgtttc tctcactgtt tatacgttat tcatgattga tggctactat aatgtcctct gggaaaagct tgacgattat gtctactacg ttcgttcaac aggcagtatt attgaattta tatttggagt tgtaatgttt ggaaatgggg cttacactat gatgtttgag tcgggaagta aaattcgggc ttttatgatg tgcctacatg catattttaa catctactta caagccaaaa atggctggaa gacatttatg aatcgtagga ctgctgtgaa gaaaattaat tcacttcctg aaataaaagg gagccgctta caagaaataa atgatgtatg tgcaatctgc tatcatgagt ttacaacatc tgctcgtatt acaccgtgta atcattattt ccatgcactt tgccttcgga aatggctgta cattcaagat acttgtccaa tgtgccatca gaaagtatac atcgaagatg atatcaagga taattcaaat gtatctaaca acaatggatt tattccaccc aatgaaactc cagaggaagc tgtaagagaa gctgctgctg aatctgacag ggaattgaac gaagatgaca gtacagattg tgatgatgat gttcaaagag aaagaaatgg agtgattcag cacacaggcg cagcagctga agaatttaat gatgatactg actga. It is sometimes possible for the material contained within the vial of "RNF139, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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