RGS6 cdna clone
RGS6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Uniprot Description
RGS6: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. 11 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cytosol; extrinsic to membrane; plasma membrane
Molecular Function: GTPase activator activity; protein binding
Biological Process: positive regulation of GTPase activity; regulation of G-protein coupled receptor protein signaling pathway
Research Articles on RGS6
Similar Products
Product Notes
The RGS6 rgs6 (Catalog #AAA1272383) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggctcaag gatccgggga tcaaagagca gtgggggttg ctgacccaga ggagagttct ccaaacatga tcgtttactg caaaattgaa gacatcatta caaagatgca agatgacaag acagggggtg tgcccatcag aacagtcaag agctttctct ccaaaatccc cagtgtcgtc acaggtactg acattgtgca gtggcttatg aagaaccttt ccattgagga cccagttgaa gcaatacact tggggagcct tatcgctgcc cagggctaca tctttccaat ctcagaccat gttctcacca tgaaggatga tggcaccttt tatcgtttcc aggctccgta cttctggcct tcgaactgct gggaacctga aaacactgac tatgccatct atctctgtaa gaggacaatg caaaataaag caaggctgga actggcagat tatgaagcag aaaacttagc aagactccag agggcctttg cgaggaagtg ggaattcatc tttatgcaag cagaagcaca agtaaagatt gaccggaaaa aagacaagac agaaaggaaa attttggata gtcaagaacg agccttttgg gatgtccaca ggcctgtgcc aggctgtgtg aacacaacag aaatggatat ccgaaaatgt cgacgtttga agaatccaca aaaggttaaa aagtccgtgt atggcgtgac tgaagagtcc caggcacaga gcccggtgca tgtactcagc caaccaatca ggaaaacaac aaaagaggac atccggaaac agataacatt tttgaacgca cagatcgaca gacattgttt gaaaatgtcc aaagtggctg aaagtttaat tgcctacacg gaacaatatg tggaatatga ccctttgata acaccagctg agccatccaa cccttggatc agcgatgacg ttgctttgtg ggacatagag atgagcaaag agcccagcca acagcgagta aaaagatggg gcttctcttt cgatgagata ttgaaggacc aggtggggcg ggaccagttt ctacgattcc tggagtccga attcagttca gaaaacctca ggttctggct ggctgtccaa gatcttaaga aacaacccct acaggatgtg gccaagaggg tagaagaaat ctggcaagag tttctggctc caggggctcc aagtgcaatc aacctggatt ctcacagcta tgagataacc agtcaaaatg tcaaagatgg agggagatat acatttgaag acgcccagga gcacatctac aagctgatga agagtgacag ctatgcccgc ttcctccggt caaatgctta ccaggatttg ctgctggcca agaagaaggg aaagtcgctg gcgggcaagc gcctcacggg cctgatgcag tcctcctga. It is sometimes possible for the material contained within the vial of "RGS6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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