RGS17 cdna clone
RGS17 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Uniprot Description
RGS17: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
Protein type: GAPs, RGS; GAPs
Chromosomal Location of Human Ortholog: 6q25.3
Molecular Function: protein binding
Research Articles on RGS17
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Product Notes
The RGS17 rgs17 (Catalog #AAA1276426) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcgaaaaa ggcagcagtc ccaaaatgaa ggaacacctg ccgtgtctca agctcctgga aaccagaggc ccaacaacac ctgttgcttt tgttggtgct gttgttgcag ctgctcctgc ctcactgtga ggaatgaaga aagaggggaa aatgcgggaa gacccacaca cactacaaaa atggagagta tccaggtcct agaggaatgc caaaacccca ctgcagagga agtcttgtcc tggtctcaaa attttgacaa gatgatgaag gccccagcag gaagaaacct tttcagagag ttcctccgaa cagaatacag tgaagagaac ctacttttct ggcttgcttg tgaagactta aagaaggagc agaacaaaaa agtaattgaa gaaaaggcta ggatgatata tgaagattac atttctatac tatcaccaaa agaggtcagt cttgattctc gagttagaga ggtgatcaat agaaatctgt tggatcccaa tcctcacatg tatgaagatg cccaacttca gatatatact ttaatgcaca gagattcttt tccaaggttt ttgaactctc aaatttataa gtcatttgtt gaaagtactg ctggctcttc ttctgaatct taa. It is sometimes possible for the material contained within the vial of "RGS17, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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