RFWD3 cdna clone
RFWD3 cDNA Clone
Gene Names
RFWD3; RNF201
Synonyms
RFWD3; RFWD3 cDNA Clone; RFWD3 cdna clone
Sequence
atggccagcagccaagggggaccagccctcctccagcctgttcctgctgatgtggtcagcagccagggggtaccatccatcctccagccagctcctgctgaggtgatcagcagccaagcgacaccacccctgctccagcctgctccgcaactgtctgttgacctgacagaagtggaggtcttgggagaagacactgtggagaacatcaatccaagaacttcagaacaacataggcagggatctgatggtaatcacaccatcccagcatcttcgttgcattcaatgaccaacttcatcagcggactgcagagacttcatggcatgctggaattcctgagaccttcatcttcaaaccacagtgtagggccaatgagaacaagaaggagggtatctgcttcacggagggcaagagccggagggtctcagaggacagacagtgccaggttgagagcaccattggatgcttactttcaggtgagcaggacccagcctgacttgccagctaccacttatgattcagagactaggaatcctgtatctgaagagttgcaggtgtctagtagttctgattctgacagtgacagctctgcagagtatggaggggttgttgaccaggcagaggaatctggagctgtcattttagaagagcaactagcaggtgtctcagcagagcaagaagttacatgtatcgatggaggcaagaccctccccaaacagccatctccccagaagtctgagcctctgctaccttctgcttctatggatgaggaagaaggggacacttgtacaatatgtctggaacagtggaccaatgctggggaccaccggctctcagcattacgctgtgggcatctctttgggtataggtgcatttccacgtggcttaaaggacaagtacgaaaatgtccccagtgcaacaagaaagccaggcacagtgacattgtcgtcctttatgcccgaaccctgagagctttggacactagtgaacaggagcgcatgaaaagttccctactgaaggaacagatgctaaggaaacaggccgagttagaatcagcacagtgccgactccaactgcaggtcctcactgataagtgcactaagcttcaaaggcgtgttcaggacttgcaaaaacttacgtcacatcaaagtcagaatttacagcaacccaggggctcccaagcatgggtcctgagctgctcaccctccagccagggccagcacaagcacaagtaccacttccaaaagaccttcacagtatctcaggcaggaaactgccggatcatggcatactgtgatgctctgagctgcctggtgatatcacagccttctcctcaggcctcttttcttccaggctttggtgttaagatgttgagtactgccaacatgaagagcagtcagtacattccgatgcatggcaaacagatccgtggactggcgtttagcagttacctcagaggcttgctactctctgcttccctagacaacactattaaactgaccagcctggagacaaataccgtggtccagacttataatgctggacgtcctgtctggagctgttgctggtgtcttgatgaggctaactacatctatgctggactggccaatggttcaattctggtatatgacgtgcgaaacacgagcagtcatgtgcaggagttagtagctcagaaagccagatgcccactggtctccctgtcatacatgcccagagctgcctcagctgcatttccatatggtggggtgctggctggaaccttggaggatgcttcattctgggaacagaaaatggacttttctcattggcctcatgtgctgcccttggagccagggggctgcatagactttcagacagagaacagctcccggcactgtcttgtgacctacaggcctgataaaaatcacaccaccatacgaagtgtgctgatggaaatgtcctaccgactggatgacactggaaatccaatctgctcctgccagcctgtacatacattttttggaggacctacttgcaaactattgaccaaaaatgccattttccaaagcccagagaatgatggcaacatcctggtgtgtactggggatgaagcagcaaattctgccctgctgtgggatgctgccagtggctcgttgctccaggacctacagaccgatcagcctgtgttggacatctgcccatttgaggtgaaccgtaacagctacttggctaccttaacagagaagatggtccacacctataagtgggagtga
Sequence Length
2250
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
85,094 Da
NCBI Official Full Name
Homo sapiens ring finger and WD repeat domain 3, mRNA
NCBI Official Synonym Full Names
ring finger and WD repeat domain 3
NCBI Official Symbol
RFWD3
NCBI Official Synonym Symbols
RNF201
NCBI Protein Information
E3 ubiquitin-protein ligase RFWD3
UniProt Protein Name
E3 ubiquitin-protein ligase RFWD3
Protein Family
UniProt Gene Name
RFWD3
UniProt Synonym Gene Names
RNF201
UniProt Entry Name
RFWD3_HUMAN
Uniprot Description
RFWD3: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: p53 binding; protein binding; ubiquitin-protein ligase activity
Biological Process: G1 DNA damage checkpoint; positive regulation of defense response to virus by host; protein ubiquitination; response to ionizing radiation
Research Articles on RFWD3
Similar Products
Product Notes
The RFWD3 rfwd3 (Catalog #AAA1271919) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccagca gccaaggggg accagccctc ctccagcctg ttcctgctga tgtggtcagc agccaggggg taccatccat cctccagcca gctcctgctg aggtgatcag cagccaagcg acaccacccc tgctccagcc tgctccgcaa ctgtctgttg acctgacaga agtggaggtc ttgggagaag acactgtgga gaacatcaat ccaagaactt cagaacaaca taggcaggga tctgatggta atcacaccat cccagcatct tcgttgcatt caatgaccaa cttcatcagc ggactgcaga gacttcatgg catgctggaa ttcctgagac cttcatcttc aaaccacagt gtagggccaa tgagaacaag aaggagggta tctgcttcac ggagggcaag agccggaggg tctcagagga cagacagtgc caggttgaga gcaccattgg atgcttactt tcaggtgagc aggacccagc ctgacttgcc agctaccact tatgattcag agactaggaa tcctgtatct gaagagttgc aggtgtctag tagttctgat tctgacagtg acagctctgc agagtatgga ggggttgttg accaggcaga ggaatctgga gctgtcattt tagaagagca actagcaggt gtctcagcag agcaagaagt tacatgtatc gatggaggca agaccctccc caaacagcca tctccccaga agtctgagcc tctgctacct tctgcttcta tggatgagga agaaggggac acttgtacaa tatgtctgga acagtggacc aatgctgggg accaccggct ctcagcatta cgctgtgggc atctctttgg gtataggtgc atttccacgt ggcttaaagg acaagtacga aaatgtcccc agtgcaacaa gaaagccagg cacagtgaca ttgtcgtcct ttatgcccga accctgagag ctttggacac tagtgaacag gagcgcatga aaagttccct actgaaggaa cagatgctaa ggaaacaggc cgagttagaa tcagcacagt gccgactcca actgcaggtc ctcactgata agtgcactaa gcttcaaagg cgtgttcagg acttgcaaaa acttacgtca catcaaagtc agaatttaca gcaacccagg ggctcccaag catgggtcct gagctgctca ccctccagcc agggccagca caagcacaag taccacttcc aaaagacctt cacagtatct caggcaggaa actgccggat catggcatac tgtgatgctc tgagctgcct ggtgatatca cagccttctc ctcaggcctc ttttcttcca ggctttggtg ttaagatgtt gagtactgcc aacatgaaga gcagtcagta cattccgatg catggcaaac agatccgtgg actggcgttt agcagttacc tcagaggctt gctactctct gcttccctag acaacactat taaactgacc agcctggaga caaataccgt ggtccagact tataatgctg gacgtcctgt ctggagctgt tgctggtgtc ttgatgaggc taactacatc tatgctggac tggccaatgg ttcaattctg gtatatgacg tgcgaaacac gagcagtcat gtgcaggagt tagtagctca gaaagccaga tgcccactgg tctccctgtc atacatgccc agagctgcct cagctgcatt tccatatggt ggggtgctgg ctggaacctt ggaggatgct tcattctggg aacagaaaat ggacttttct cattggcctc atgtgctgcc cttggagcca gggggctgca tagactttca gacagagaac agctcccggc actgtcttgt gacctacagg cctgataaaa atcacaccac catacgaagt gtgctgatgg aaatgtccta ccgactggat gacactggaa atccaatctg ctcctgccag cctgtacata cattttttgg aggacctact tgcaaactat tgaccaaaaa tgccattttc caaagcccag agaatgatgg caacatcctg gtgtgtactg gggatgaagc agcaaattct gccctgctgt gggatgctgc cagtggctcg ttgctccagg acctacagac cgatcagcct gtgttggaca tctgcccatt tgaggtgaac cgtaacagct acttggctac cttaacagag aagatggtcc acacctataa gtgggagtga. It is sometimes possible for the material contained within the vial of "RFWD3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
