RAPGEF4 cdna clone
RAPGEF4 cDNA Clone
Gene Names
RAPGEF4; EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
Synonyms
RAPGEF4; RAPGEF4 cDNA Clone; RAPGEF4 cdna clone
Sequence
atggtcgctgcgcacgctgcccattcttcctcctctgccgagtggatcgcctgcctggataaaagaccactggagcgatccagcgaagatgtggatataatcttcactcgactgaaagaagttaaagcttttgagaaatttcacccaaatctccttcatcagatttgcttatgtggttattatgagaatctggaaaagggaataacattatttcgccagggtgatattggaacaaactggtatgctgtcctggcagggtctttggatgttaaagtatctgagaccagcagtcaccaggatgctgtgaccatctgtaccctgggaattgggacggcctttggagagtccattctggacaacacaccccgccatgcaaccatcgttaccagggagagcagtgaactgctccgcatcgagcagaaggacttcaaggcactatgggagaaatatcgacagtatatggcaggacttctggctcctccttatggtgttatggaaacgggctctaacaatgacaggattcctgacaaggagaacacacctctcattgaacctcacgttcctcttcgtcctgctaacaccattaccaaggtcccttcagagaagatcctcagagctggaaaaattttacgaaatgccattctctctcgagcacctcacatgataagagatagaaaataccacctaaagacatacagacaatgctgtgtgggaactgaactggtggactggatgatgcagcagacaccatgtgttcactcccggactcaagctgttggcatgtggcaagtcctgttagaagatggtgttctcaaccacgtggaccaggagcaccatttccaagacaaatatttattctatcgatttctggatgatgagcacgaggatgcccctttgcctactgaggaggagaagaaggagtgtgatgaggagctccaggacaccatgctgctgctgtcacagatgggccccgacgcccacatgaggatgatccttcgcaaaccacctggccagaggactgtggatgacctagagattatctatgaggagcttcttcatattaaagccttatcccatctttctaccacagtgaaacgagagttagcaggtgttctcatttttgagtctcacgccaaaggagggactgtgttgtttaaccagggggaagaaggtacctcctggtacattattctaaaaggatcagtgaatgtagtcatttacggcaagggtgtggtctgcaccctgcatgaaggagatgacttcggcaagttagcactagtgaatgatgccccacgagctgcctctatcgtcttacgagaagataactgccatttcttaagagtagacaaggaggatttcaaccggatcctaagggacgtggaggcgaatacagtcagacttaaagaacatgaccaagatgtcttggtgctggagaaggtcccagcagggaacagagcttctaatcaaggaaactcacagcctcagcaaaagtatactgtgatgtcaggaacacctgaaaaaattttagagcattttctagaaacaatacgccttgaggcaactttaaatgaagcaacagattctgttttaaatgactttattatgatgcactgtgtttttatgccaaatacccagctttgcccggcactggtggcccactaccacgcacagccttcacaaggtacagaacaggagaaaatggattatgccctcaacaataagaggcgagtcatccgcctggttctacagtgggctgccatgtatggagacctcctgcaagaggatgacgtgtctatggccttcctggaggagttttatgtatctgtatcagatgatgcccggatgattgctgccctcaaggagcaactgccagagttggagaagattgtcaagcaaatctcagaagatgcaaaggcaccacaaaagaagcacaaggttcttttgcaacagttcaatacgggcgatgagagagcccagaagcgccagcctatccgcggctctgatgaagttctgtttaaggtctattgcatggaccccacctacacaaccattcgggtgccagtggccacttcggtgaaggaagtcatcagtgcagttgccgacaagctgggctccggggagggcctgatcatagtcaagatgagttccggaggagaaaaggtggtgctcaaacctaatgatgtttcagtatttatgacgctcaccattaatggacgcctgtttgcttgcccgcgagagcaattcgattcactgactcccttaccagaacaggaaggcccaactgttggaacagtgggaacttttgaactgatgagctccaaagatttagcataccagatgacaatttatgattgggaactcttcaactgcgtgcatgagctggagctaatctatcacacatttggaaggcataattttaaaaagaccacagcaaacttggatttgttcctgaggagatttaatgaaattcagttttgggtcgtcactgagatctgcctttgttctcagctcagcaagcgtgttcagctattaaaaaaatttattaagatagcagcccactgtaaggagtataaaaatctgaattccttttttgccatcgtcatgggactaagtaacgttgctgtgagccgcttggcactaacgtgggagaaactgccaagcaagttcaagaagttctatgcggagtttgaaagtttaatggacccttcaaggaaccacagggcctacaggctgacagtagctaagctggaacctcctctcatccccttcatgcctttgctcattaaagatatgacatttactcatgaggggaacaagacgttcattgacaatctagtaaactttgaaaaaatgcgcatgattgcaaatacggccagaacagtgagatactacaggagccaacccttcaatcctgatgcagctcaagctaataagaaccatcaggatgtccggagttatgtacggcaattaaatgtgattgacaaccagagaactttatcacagatgtcacacagattagagcctcgtcgaccatag
Sequence Length
3036
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
96,269 Da
NCBI Official Full Name
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4, mRNA
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 4
NCBI Official Symbol
RAPGEF4
NCBI Official Synonym Symbols
EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
NCBI Protein Information
rap guanine nucleotide exchange factor 4
UniProt Protein Name
Rap guanine nucleotide exchange factor 4
Protein Family
UniProt Gene Name
RAPGEF4
UniProt Synonym Gene Names
CGEF2; EPAC2; EPAC 2; cAMP-GEFII
UniProt Entry Name
RPGF4_HUMAN
Uniprot Description
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: GEFs, Ras; GEFs
Chromosomal Location of Human Ortholog: 2q31-q32
Cellular Component: membrane; plasma membrane
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: G-protein coupled receptor protein signaling pathway; regulation of insulin secretion
Research Articles on RAPGEF4
Similar Products
Product Notes
The RAPGEF4 rapgef4 (Catalog #AAA1271031) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtcgctg cgcacgctgc ccattcttcc tcctctgccg agtggatcgc ctgcctggat aaaagaccac tggagcgatc cagcgaagat gtggatataa tcttcactcg actgaaagaa gttaaagctt ttgagaaatt tcacccaaat ctccttcatc agatttgctt atgtggttat tatgagaatc tggaaaaggg aataacatta tttcgccagg gtgatattgg aacaaactgg tatgctgtcc tggcagggtc tttggatgtt aaagtatctg agaccagcag tcaccaggat gctgtgacca tctgtaccct gggaattggg acggcctttg gagagtccat tctggacaac acaccccgcc atgcaaccat cgttaccagg gagagcagtg aactgctccg catcgagcag aaggacttca aggcactatg ggagaaatat cgacagtata tggcaggact tctggctcct ccttatggtg ttatggaaac gggctctaac aatgacagga ttcctgacaa ggagaacaca cctctcattg aacctcacgt tcctcttcgt cctgctaaca ccattaccaa ggtcccttca gagaagatcc tcagagctgg aaaaatttta cgaaatgcca ttctctctcg agcacctcac atgataagag atagaaaata ccacctaaag acatacagac aatgctgtgt gggaactgaa ctggtggact ggatgatgca gcagacacca tgtgttcact cccggactca agctgttggc atgtggcaag tcctgttaga agatggtgtt ctcaaccacg tggaccagga gcaccatttc caagacaaat atttattcta tcgatttctg gatgatgagc acgaggatgc ccctttgcct actgaggagg agaagaagga gtgtgatgag gagctccagg acaccatgct gctgctgtca cagatgggcc ccgacgccca catgaggatg atccttcgca aaccacctgg ccagaggact gtggatgacc tagagattat ctatgaggag cttcttcata ttaaagcctt atcccatctt tctaccacag tgaaacgaga gttagcaggt gttctcattt ttgagtctca cgccaaagga gggactgtgt tgtttaacca gggggaagaa ggtacctcct ggtacattat tctaaaagga tcagtgaatg tagtcattta cggcaagggt gtggtctgca ccctgcatga aggagatgac ttcggcaagt tagcactagt gaatgatgcc ccacgagctg cctctatcgt cttacgagaa gataactgcc atttcttaag agtagacaag gaggatttca accggatcct aagggacgtg gaggcgaata cagtcagact taaagaacat gaccaagatg tcttggtgct ggagaaggtc ccagcaggga acagagcttc taatcaagga aactcacagc ctcagcaaaa gtatactgtg atgtcaggaa cacctgaaaa aattttagag cattttctag aaacaatacg ccttgaggca actttaaatg aagcaacaga ttctgtttta aatgacttta ttatgatgca ctgtgttttt atgccaaata cccagctttg cccggcactg gtggcccact accacgcaca gccttcacaa ggtacagaac aggagaaaat ggattatgcc ctcaacaata agaggcgagt catccgcctg gttctacagt gggctgccat gtatggagac ctcctgcaag aggatgacgt gtctatggcc ttcctggagg agttttatgt atctgtatca gatgatgccc ggatgattgc tgccctcaag gagcaactgc cagagttgga gaagattgtc aagcaaatct cagaagatgc aaaggcacca caaaagaagc acaaggttct tttgcaacag ttcaatacgg gcgatgagag agcccagaag cgccagccta tccgcggctc tgatgaagtt ctgtttaagg tctattgcat ggaccccacc tacacaacca ttcgggtgcc agtggccact tcggtgaagg aagtcatcag tgcagttgcc gacaagctgg gctccgggga gggcctgatc atagtcaaga tgagttccgg aggagaaaag gtggtgctca aacctaatga tgtttcagta tttatgacgc tcaccattaa tggacgcctg tttgcttgcc cgcgagagca attcgattca ctgactccct taccagaaca ggaaggccca actgttggaa cagtgggaac ttttgaactg atgagctcca aagatttagc ataccagatg acaatttatg attgggaact cttcaactgc gtgcatgagc tggagctaat ctatcacaca tttggaaggc ataattttaa aaagaccaca gcaaacttgg atttgttcct gaggagattt aatgaaattc agttttgggt cgtcactgag atctgccttt gttctcagct cagcaagcgt gttcagctat taaaaaaatt tattaagata gcagcccact gtaaggagta taaaaatctg aattcctttt ttgccatcgt catgggacta agtaacgttg ctgtgagccg cttggcacta acgtgggaga aactgccaag caagttcaag aagttctatg cggagtttga aagtttaatg gacccttcaa ggaaccacag ggcctacagg ctgacagtag ctaagctgga acctcctctc atccccttca tgcctttgct cattaaagat atgacattta ctcatgaggg gaacaagacg ttcattgaca atctagtaaa ctttgaaaaa atgcgcatga ttgcaaatac ggccagaaca gtgagatact acaggagcca acccttcaat cctgatgcag ctcaagctaa taagaaccat caggatgtcc ggagttatgt acggcaatta aatgtgattg acaaccagag aactttatca cagatgtcac acagattaga gcctcgtcga ccatag. It is sometimes possible for the material contained within the vial of "RAPGEF4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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