PYHIN1 cdna clone
PYHIN1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
PYHIN1: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. Belongs to the HIN-200 family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q23.1
Research Articles on PYHIN1
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Product Notes
The PYHIN1 pyhin1 (Catalog #AAA1265929) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCAAATA ACTACAAGAA AATTGTTCTA CTGAAAGGAT TAGAGGTCAT CAATGATTAT CATTTTAGAA TTGTTAAGTC CTTACTGAGT AACGATTTAA AACTTAATCC AAAAATGAAA GAAGAGTATG ACAAAATTCA GATTGCTGAC TTGATGGAGG AAAAGTTCCC AGGTGATGCC GGTTTGGGCA AACTAATAGA ATTCTTCAAA GAAATACCAA CACTGGGAGA CCTTGCTGAA ACTCTTAAAA GAGAAAAGTT AAAAGTCAAA GGAATAATCC CATCTAAAAA GACGAAACAG AAAGAAGTGT ATCCTGCTAC ACCTGCATGC ACCCCAAGCA ACCGTCTCAC AGCTAAAGGA GCAGAGGAGA CTCTTGGACC TCAGAAAAGA AAAAAACCAT CTGAAGAAGA GACTGGAACC AAAAGGAGTA AGATGTCCAA AGAGCAGACT CGGCCTTCCT GCTCTGCAGG AGCCAGCACG TCCACAGCCA TGGGCCGTTC CCCACCTCCC CAGACCTCAT CATCAGCTCC ACCCAACACT TCCTCAACTG AGAGCCTAAA ACCATTGGCC AACCGTCACG CAACTGCCAG TAAAAATATT TTCCGAGAAG ACCCAATAAT CGCGATGGTA CTAAATGCAA CAAAAGTATT TAAATATGAA TCCTCAGAAA ATGAGCAAAG AAGAATGTTT CATGCTACAG TGGCTACGCA GACACAGTTC TTTCATGTGA AGGTTTTAAA CATCAACTTG AAGAGGAAAT TCATTAAAAA GAGAATCATC ATTATATCAA ATTATTCCAA ACGTAATAGT CTCCTAGAGG TGAATGAAGC CTCTTCTGTA TCTGAAGCTG GTCCTGACCA AACGTTTGAG GTTCCAAAGG ACATCATCAG AAGAGCAAAG AAAATTCCGA AGATCAATAT TCTTCACAAA CAAACTTCAG GATATATTGT ATATGGATTA TTTATGCTAC ATACGAAAAT TGTAAATAGG AAGACGACAA TCTATGAAAT TCAGGATAAA ACAGGAAGTA TGGCTGTAGT AGGAAAAGGA GAATGCCACA ATATCCCCTG TGAAAAAGGA GATAAGCTTC GACTCTTCTG CTTTCGACTG AGAAAGAGGG AAAATATGTC AAAACTGATG TCAGAAATGC ATAGTTTCAT CCAGATACAG AAAAATACAA ACCAGAGAAG CCATGACTCC AGGAGCATGG CACTACCCCA GGAACAGAGT CAGCATCCAA AACCTTCAGA GGCCAGCACA ACCCTACCTG AAAGCCATCT CAAGACTCCT CAGATGCCAC CAACAACCCC ATCCAGCAGT TCCTTCACCA AGAAGGATGA AACCCACCCA GGAGCACAGT CATCGCCTGC AAACTTTAGA ATCACCTCAC CAACTGTGGC CCCTCCTCTT TCTTCTGACA CTTCCACCAA CCGCCATCCA GCAGTTCCTT AA. It is sometimes possible for the material contained within the vial of "PYHIN1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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