PRPF31 cdna clone
PRPF31 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]
Uniprot Description
PRPF31: Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation. Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant. Belongs to the PRP31 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: Cajal body; nuclear speck; nucleoplasm; nucleus; U4/U6 x U5 tri-snRNP complex
Molecular Function: protein binding; ribonucleoprotein binding; U4 snRNA binding; U4atac snRNA binding
Biological Process: assembly of spliceosomal tri-snRNP; nuclear mRNA splicing, via spliceosome; snoRNA localization
Disease: Retinitis Pigmentosa 11
Research Articles on PRPF31
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Product Notes
The PRPF31 prpf31 (Catalog #AAA1265780) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctctgg cagatgagct cttagctgat ctcgaagagg cagcagaaga ggaggaagga ggaagctatg gggaggaaga agaggagcca gcgatcgagg atgtgcagga ggagacacag ctggatcttt ccggggattc agtcaagacc atcgccaagc tatgggatag taagatgttt gctgagatta tgatgaagat tgaggagtat atcagcaagc aagccaaagc ttcagaagtg atgggaccag tggaggccgc gcctgaatac cgcgtcatcg tggatgccaa caacctgacc gtggagatcg aaaacgagct gaacatcatc cataagttca tccgggataa gtactcaaag agattccctg aactggagtc cttggtcccc aatgcactgg attacatccg cacggtcaag gagctgggca acagcctgga caagtgcaag aacaatgaga acctgcagca gatcctcacc aatgccacca tcatggtcgt cagcgtcacc gcctccacca cccaggggca gcagctgtcg gaggaggagc tggagcggct ggaggaggcc tgcgacatgg cgctggagct gaacgcctcc aagcaccgca tctacgagta tgtggagtcc cggatgtcct tcatcgcacc caacctgtcc atcattatcg gggcatccac ggccgccaag atcatgggtg tggccggcgg cctgaccaac ctctccaaga tgcccgcctg caacatcatg ctgctcgggg cccagcgcaa gacgctgtcg ggcttctcgt ctacctcagt gctgccccac accggctaca tctaccacag tgacatcgtg cagtccctgc caccggatct gcggcggaaa gcggcccggc tggtggccgc caagtgcaca ctggcagccc gtgtggacag tttccacgag agcacagaag ggaaggtggg ctacgaactg aaggatgaga tcgagcgcaa attcgacaag tggcaggagc cgccgcctgt gaagcaggtg aagccgctgc ctgcgcccct ggatggacag cggaagaagc gaggcggccg caggtaccgc aagatgaagg agcggctggg gctgacggag atccggaagc aggccaaccg tatgagcttc ggagagatcg aggaggacgc ctaccaggag gacctgggat tcagcctggg ccacctgggc aagtcgggca gtgggcgtgt gcggcagaca caggtaaacg aggccaccaa ggccaggatc tccaagacgc tgcagcggac cctgcagaag cagagcgtcg tatatggcgg gaagtccacc atccgcgacc gctcctcggg cacggcctcc agcgtggcct tcaccccact ccagggcctg gagattgtga acccacaggc ggcagagaag aaggtggctg aggccaacca gaagtatttc tccagcatgg ctgagttcct caaggtcaag ggcgagaaga gtggccttat gtccacctga. It is sometimes possible for the material contained within the vial of "PRPF31, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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