PRKCA cdna clone
PRKCA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Uniprot Description
PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.
Protein type: Kinase, protein; Protein kinase, AGC; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Alpha subfamily
Chromosomal Location of Human Ortholog: 17q22-q23.2
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
Molecular Function: calcium-dependent protein kinase C activity; enzyme binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: adenylate cyclase activation; mitotic nuclear envelope disassembly; negative regulation of adenylate cyclase activity; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; regulation of insulin secretion; regulation of mRNA stability
Research Articles on PRKCA
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Product Notes
The PRKCA prkca (Catalog #AAA1271168) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTGACG TTTTCCCGGG CAACGACTCC ACGGCGTCTC AGGACGTGGC CAACCGCTTC GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TCCACAAGAG GTGCCATGAA TTTGTTACTT TTTCTTGTCC GGGTGCGGAT AAGGGACCCG ACACTGATGA CCCCAGGAGC AAGCACAAGT TCAAAATCCA CACTTACGGA AGCCCCACCT TCTGCGATCA CTGTGGGTCA CTGCTCTATG GACTTATCCA TCAAGGGATG AAATGTGACA CCTGCGATAT GAACGTTCAC AAGCAATGCG TCATCAATGT CCCCAGCCTC TGCGGAATGG ATCACACTGA GAAGAGGGGG CGGATTTACC TAAAGGCTGA GGTTGCTGAT GAAAAGCTCC ATGTCACAGT ACGAGATGCA AAAAATCTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT ATTCCTGATC CCAAGAATGA AAGCAAGCAA AAAACCAAAA CCATCCGCTC CACACTAAAT CCGCAGTGGA ATGAGTCCTT TACATTCAAA TTGAAACCTT CAGACAAAGA CCGACGACTG TCTGTAGAAA TCTGGGACTG GGATCGAACA ACAAGGAATG ACTTCATGGG ATCCCTTTCC TTTGGAGTTT CGGAGCTGAT GAAGATGCCG GCCAGTGGAT GGTACAAGTT GCTTAACCAA GAAGAAGGTG AGTACTACAA CGTACCCATT CCGGAAGGGG ACGAGGAAGG AAACATGGAA CTCAGGCAGA AATTCGAGAA AGCCAAACTT GGCCCTGCTG GCAACAAAGT CATCAGTCCC TCTGAAGACA GGAAACAACC TTCCAACAAC CTTGACCGAG TGAAACTCAC GGACTTCAAT TTCCTCATGG TGTTGGGAAA GGGGAGTTTT GGAAAGGTGA TGCTTGCCGA CAGGAAGGGC ACAGAAGAAC TGTATGCAAT CAAAATCCTG AAGAAGGATG TGGTGATTCA GGATGATGAC GTGGAGTGCA CCATGGTAGA AAAGCGAGTC TTGGCCCTGC TTGACAAACC CCCGTTCTTG ACGCAGCTGC ACTCCTGCTT CCAGACAGTG GATCGGCTGT ACTTCGTCAT GGAATATGTC AACGGTGGGG ACCTCATGTA CCACATTCAG CAAGTAGGAA AATTTAAGGA ACCACAAGCA GTATTCTATG CGGCAGAGAT TTCCATCGGA TTGTTCTTTC TTCATAAAAG AGGAATCATT TATAGGGATC TGAAGTTAGA TAACGTCATG TTGGATTCAG AAGGACATAT CAAAATTGCT GACTTTGGGA TGTGCAAGGA ACACATGATG GATGGAGTCA CGACCAGGAC CTTCTGTGGG ACTCCAGATT ATATCGCCCC AGAGATAATC GCTTATCAGC CGTATGGAAA ATCTGTGGAC TGGTGGGCCT ATGGCGTCCT GTTGTATGAA ATGCTTGCCG GGCAGCCTCC ATTTGATGGT GAAGATGAAG ACGAGCTATT TCAGTCTATC ATGGAGCACA ACGTTTCCTA TCCAAAATCC TTGTCCAAGG AGGCTGTTTC TATCTGCAAA GGACTGATGA CCAAACACCC AGCCAAGCGG CTGGGCTGTG GGCCTGAGGG GGAGAGGGAC GTGAGAGAGC ATGCCTTCTT CCGGAGGATC GACTGGGAAA AACTGGAGAA CAGGGAGATC CAGCCACCAT TCAAGCCCAA AGTGTGTGGC AAAGGAGCAG AGAACTTTGA CAAGTTCTTC ACACGAGGAC AGCCCGTCTT AACACCACCT GATCAGCTGG TTATTGCTAA CATAGACCAG TCTGATTTTG AAGGGTTCTC GTATGTCAAC CCCCAGTTTG TGCACCCCAT CTTACAGAGT GCAGTATGA. It is sometimes possible for the material contained within the vial of "PRKCA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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