PRDM1 cdna clone
PRDM1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation; DNA-binding; Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: protein binding; transcription factor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation
Research Articles on PRDM1
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Product Notes
The PRDM1 prdm1 (Catalog #AAA1270137) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAAAAGA TCTATTCCAG AGGGGAGCTT CACCACTTCA TTGACGGCTT TAATGAAGAG AAAAGCAACT GGATGCGCTA TGTGAATCCA GCACACTCTC CCCGGGAGCA AAACCTGGCT GCGTGTCAGA ACGGGATGAA CATCTACTTC TACACCATTA AGCCCATCCC TGCCAACCAG GAACTTCTTG TGTGGTATTG TCGGGACTTT GCAGAAAGGC TTCACTACCC TTATCCCGGA GAGCTGACAA TGATGAATCT CACACAAACA CAGAGCAGTC TAAAGCAACC GAGCACTGAG AAAAATGAAC TCTGCCCAAA GAATGTCCCA AAGAGAGAGT ACAGCGTGAA AGAAATCCTA AAATTGGACT CCAACCCCTC CAAAGGAAAG GACCTCTACC GTTCTAACAT TTCACCCCTC ACATCAGAAA AGGACCTCGA TGACTTTAGA AGACGTGGGA GCCCCGAAAT GCCCTTCTAC CCTCGGGTCG TTTACCCCAT CCGGGCCCCT CTGCCAGAAG ACTTTTTGAA AGCTTCCCTG GCCTACGGGA TCGAGAGACC CACGTACATC ACTCGCTCCC CCATTCCATC CTCCACCACT CCAAGCCCCT CTGCAAGAAG CAGCCCCGAC CAAAGCCTCA AGAGCTCCAG CCCTCACAGC AGCCCTGGGA ATACGGTGTC CCCTGTGGGC CCCGGCTCTC AAGAGCACCG GGACTCCTAC GCTTACTTGA ACGCGTCCTA CGGCACGGAA GGTTTGGGCT CCTACCCTGG CTACGCACCC CTGCCCCACC TCCCGCCAGC TTTCATCCCC TCGTACAACG CTCACTACCC CAAGTTCCTC TTGCCCCCCT ACGGCATGAA TTGTAATGGC CTGAGCGCTG TGAGCAGCAT GAATGGCATC AACAACTTTG GCCTCTTCCC GAGGCTGTGC CCTGTCTACA GCAATCTCCT CGGTGGGGGC AGCCTGCCCC ACCCCATGCT CAACCCCACT TCTCTCCCGA GCTCGCTGCC CTCAGATGGA GCCCGGAGGT TGCTCCAGCC GGAGCATCCC AGGGAGGTGC TTGTCCCGGC GCCCCACAGT GCCTTCTCCT TTACCGGGGC CGCCGCCAGC ATGAAGGACA AGGCCTGTAG CCCCACAAGC GGGTCTCCCA CGGCGGGAAC AGCCGCCACG GCAGAACATG TGGTGCAGCC CAAAGCTACC TCAGCAGCGA TGGCAGCCCC CAGCAGCGAC GAAGCCATGA ATCTCATTAA AAACAAAAGA AACATGACCG GCTACAAGAC CCTTCCCTAC CCGCTGAAGA AGCAGAACGG CAAGATCAAG TACGAATGCA ACGTTTGCGC CAAGACTTTC GGCCAGCTCT CCAATCTGAA GGTCCACCTG AGAGTGCACA GTGGAGAACG GCCTTTCAAA TGTCAGACTT GCAACAAGGG CTTTACTCAG CTCGCCCACC TGCAGAAACA CTACCTGGTA CACACGGGAG AAAAGCCACA TGAATGCCAG GTCTGCCACA AGAGATTTAG CAGCACCAGC AATCTCAAGA CCCACCTGCG ACTCCATTCT GGAGAGAAAC CATACCAATG CAAGGTGTGC CCTGCCAAGT TCACCCAGTT TGTGCACCTG AAACTGCACA AGCGTCTGCA CACCCGGGAG CGGCCCCACA AGTGCTCCCA GTGCCACAAG AACTACATCC ATCTCTGTAG CCTCAAGGTT CACCTGAAAG GGAACTGCGC TGCGGCCCCG GCGCCTGGGC TGCCCTTGGA AGATCTGACC CGAATCAATG AAGAAATCGA GAAGTTTGAC ATCAGTGACA ATGCTGACCG GCTCGAGGAC GTGGAGGATG ACATCAGTGT GATCTCTGTA GTGGAGAAGG AAATTCTGGC CGTGGTCAGA AAAGAGAAAG AAGAAACTGG CCTGAAAGTG TCTTTGCAAA GAAACATGGG GAATGGACTC CTCTCCTCAG GGTGCAGCCT TTATGAGTCA TCAGATCTAC CCCTCATGAA GTTGCCTCCC AGCAACCCAC TACCTCTGGT ACCTGTAAAG GTCAAACAAG AAACAGTTGA ACCAATGGAT CCTTAA. It is sometimes possible for the material contained within the vial of "PRDM1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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