POLR3E cdna clone
POLR3E cDNA Clone
Gene Names
POLR3E; SIN; RPC5
Synonyms
POLR3E; POLR3E cDNA Clone; POLR3E cdna clone
Sequence
atggccaatgaagaggatgacccagttgtacaggagatcgatgtgtacttggccaagagtctggcggaaaagctgtatctatttcagtaccctgtgcgtccagcctcgatgacctacgatgacattccgcacctctcagccaagatcaagcccaagcagcagaaggtagagcttgagatggccatcgacaccctgaaccccaactattgccgcagcaaaggggagcagattgcgctgaacgtggacggggcctgcgccgacgagaccagcacgtattcctcgaagctgatggacaagcagaccttctgctcttcccagaccaccagtaacacatcccgttatgccgctgcactctacaggcaaggtgagctccacctgacacctttacatggcatcctgcagctgcggcccagcttctcctacctggataaggctgacgccaagcaccgggagagggaggcggccaacgaggcaggggactcttcacaggatgaggcggaagacgatgttaagcagatcacggtgcggttctcccggccggagtcagagcaggcccgccagcgccgtgtgcagtcctatgagttcctgcagaagaagcacgcagaggagccctgggtccacctgcattactatggcctgagggacagtcgctctgagcatgagcgtcagtacctgctgtgccccggctcaagcggggtggagaacacggagctcgtcaagtcacccagtgagtacctgatgatgctgatgccacccagccaggaggaggagaaagacaagcctgtggcccccagcaacgtcctgtcgatggcccagctgcgcacgctgcccctggccgatcagatcaagatcctgatgaagaatgtgaaggtcatgccttttgccaacttgatgagcctcctgggcccctccatcgattccgtggctgttctgcggggcatccagaaggtggcgatgttggtccaagggaactgggtggtgaagagtgacatcctataccccaaggactcgtccagccctcacagcggcgtgcctgctgaggtgctctgcaggggccgagacttcgttatgtggaagttcacgcagagccgctgggtggttaggaaagaggtggcaaccgtgaccaaactctgcgccgaggatgtgaaggacttcctggagcacatggccgtggtgaggatcaacaaaggctgggagttcattctgccttatgatggggagttcatcaagaagcacccggatgtggtccagcggcagcacatgctgtggacgggtatccaggccaaactggaaaaagtctataatcttgtaaaggaaaccatgccaaagaagccggatgcacaatcagggcctgccgggctggtctgtggggaccagcggatccaagtagccaaaaccaaggcccagcagaaccacgcgttgctggagcgggagctgcagcggcggaaggagcagctgcgggtgcctgcggtcccgcccggtgtgcggatcaaggaggagcccgtgagcgaggagggcgaggaggacgaggagcaggaggcggaggaggagcccatggacacttcccccagcggcctccacagcaagctggccaacgggctgcctctcgggcgggctgcgggcacagacagcttcaacgggcacccgccccagggctgcgccagcacccctgtggctcgggaactgaaggccttcgtggaggccacctttcagagacagtttgtgctcacgctgagcgaactcaagcgcctcttcaatctgcacttggccagcctgccccccggccacacactcttcagcggcatctcggaccgcatgctacaggacacggtgctggccgccggttgcaagcagatactggtgccttttcccccccagactgctgcttccccggatgagcagaaggtgtttgccctctgggagtctggagacatgagtgatcaggactgctgtgtaagctatggtggcatgtggtaccttaaagggacagtacagtcttga
Sequence Length
2001
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
75,758 Da
NCBI Official Full Name
Homo sapiens polymerase (RNA) III (DNA directed) polypeptide E (80kD), mRNA
NCBI Official Synonym Full Names
RNA polymerase III subunit E
NCBI Official Symbol
POLR3E
NCBI Official Synonym Symbols
SIN; RPC5
NCBI Protein Information
DNA-directed RNA polymerase III subunit RPC5
UniProt Protein Name
DNA-directed RNA polymerase III subunit RPC5
Protein Family
UniProt Gene Name
POLR3E
UniProt Synonym Gene Names
KIAA1452; RNA polymerase III subunit C5
UniProt Entry Name
RPC5_HUMAN
Uniprot Description
POLR3E: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; Transcription initiation complex; EC 2.7.7.6
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nucleoplasm
Biological Process: positive regulation of interferon type I production
Research Articles on POLR3E
Similar Products
Product Notes
The POLR3E polr3e (Catalog #AAA1267767) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccaatg aagaggatga cccagttgta caggagatcg atgtgtactt ggccaagagt ctggcggaaa agctgtatct atttcagtac cctgtgcgtc cagcctcgat gacctacgat gacattccgc acctctcagc caagatcaag cccaagcagc agaaggtaga gcttgagatg gccatcgaca ccctgaaccc caactattgc cgcagcaaag gggagcagat tgcgctgaac gtggacgggg cctgcgccga cgagaccagc acgtattcct cgaagctgat ggacaagcag accttctgct cttcccagac caccagtaac acatcccgtt atgccgctgc actctacagg caaggtgagc tccacctgac acctttacat ggcatcctgc agctgcggcc cagcttctcc tacctggata aggctgacgc caagcaccgg gagagggagg cggccaacga ggcaggggac tcttcacagg atgaggcgga agacgatgtt aagcagatca cggtgcggtt ctcccggccg gagtcagagc aggcccgcca gcgccgtgtg cagtcctatg agttcctgca gaagaagcac gcagaggagc cctgggtcca cctgcattac tatggcctga gggacagtcg ctctgagcat gagcgtcagt acctgctgtg ccccggctca agcggggtgg agaacacgga gctcgtcaag tcacccagtg agtacctgat gatgctgatg ccacccagcc aggaggagga gaaagacaag cctgtggccc ccagcaacgt cctgtcgatg gcccagctgc gcacgctgcc cctggccgat cagatcaaga tcctgatgaa gaatgtgaag gtcatgcctt ttgccaactt gatgagcctc ctgggcccct ccatcgattc cgtggctgtt ctgcggggca tccagaaggt ggcgatgttg gtccaaggga actgggtggt gaagagtgac atcctatacc ccaaggactc gtccagccct cacagcggcg tgcctgctga ggtgctctgc aggggccgag acttcgttat gtggaagttc acgcagagcc gctgggtggt taggaaagag gtggcaaccg tgaccaaact ctgcgccgag gatgtgaagg acttcctgga gcacatggcc gtggtgagga tcaacaaagg ctgggagttc attctgcctt atgatgggga gttcatcaag aagcacccgg atgtggtcca gcggcagcac atgctgtgga cgggtatcca ggccaaactg gaaaaagtct ataatcttgt aaaggaaacc atgccaaaga agccggatgc acaatcaggg cctgccgggc tggtctgtgg ggaccagcgg atccaagtag ccaaaaccaa ggcccagcag aaccacgcgt tgctggagcg ggagctgcag cggcggaagg agcagctgcg ggtgcctgcg gtcccgcccg gtgtgcggat caaggaggag cccgtgagcg aggagggcga ggaggacgag gagcaggagg cggaggagga gcccatggac acttccccca gcggcctcca cagcaagctg gccaacgggc tgcctctcgg gcgggctgcg ggcacagaca gcttcaacgg gcacccgccc cagggctgcg ccagcacccc tgtggctcgg gaactgaagg ccttcgtgga ggccaccttt cagagacagt ttgtgctcac gctgagcgaa ctcaagcgcc tcttcaatct gcacttggcc agcctgcccc ccggccacac actcttcagc ggcatctcgg accgcatgct acaggacacg gtgctggccg ccggttgcaa gcagatactg gtgccttttc ccccccagac tgctgcttcc ccggatgagc agaaggtgtt tgccctctgg gagtctggag acatgagtga tcaggactgc tgtgtaagct atggtggcat gtggtacctt aaagggacag tacagtcttg a. It is sometimes possible for the material contained within the vial of "POLR3E, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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