PKD2 cdna clone
PKD2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
Uniprot Description
PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: basal cortex; basal plasma membrane; cilium; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; filamentous actin; integral to plasma membrane; intercellular junction; lamellipodium; motile primary cilium; nonmotile primary cilium; plasma membrane
Molecular Function: actinin binding; ATPase binding; calcium ion binding; calcium-induced calcium release activity; cytoskeletal protein binding; HLH domain binding; identical protein binding; phosphoprotein binding; potassium channel activity; protein binding; protein homodimerization activity; receptor binding; voltage-gated calcium channel activity; voltage-gated cation channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity
Biological Process: calcium ion transport; cell cycle arrest; cytoplasmic sequestering of transcription factor; detection of mechanical stimulus; determination of left/right symmetry; embryonic placenta development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; heart development; heart looping; JAK-STAT cascade; liver development; neural tube development; positive regulation of inositol-1,4,5-triphosphate receptor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cAMP metabolic process; regulation of cell proliferation; release of sequestered calcium ion into cytosol; spinal cord development; ureteric bud branching
Disease: Polycystic Kidney Disease 2
Research Articles on PKD2
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Product Notes
The PKD2 pkd2 (Catalog #AAA1278191) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGTGAACT CCAGTCGCGT GCAGCCTCAG CAGCCCGGGG ACGCCAAGCG GCCGCCCGCG CCCCGCGCGC CGGACCCGGG CCGGCTGATG GCTGGCTGCG CGGCCGTGGG CGCCAGCCTC GCCGCCCCGG GCGGCCTCTG CGAGCAGCGG GGCCTGGAGA TCGAGATGCA GCGCATCCGG CAGGCGGCCG CGCGGGACCC CCCGGCCGGA GCCGCGGCCT CCCCTTCTCC TCCGCTCTCG TCGTGCTCCC GGCAGGCGTG GAGCCGCGAT AACCCCGGCT TCGAGGCCGA GGAGGAGGAG GAGGAGGTGG AAGGGGAAGA AGGCGGAATG GTGGTGGAGA TGGACGTAGA GTGGCGCCCG GGCAGCCGGA GGTCGGCCGC CTCCTCGGCC GTGAGCTCCG TGGGCGCGCG GAGCCGGGGG CTTGGGGGCT ACCACGGCGC GGGCCACCCG AGCGGGAGGC GGCGCCGGCG AGAGGACCAG GGCCCGCCGT GCCCCAGCCC AGTCGGCGGC GGGGACCCGC TGCATCGCCA CCTCCCCCTG GAAGGGCAGC CGCCCCGAGT GGCCTGGGCG GAGAGGCTGG TTCGCGGGCT GCGAGGTCTC TGGGGAACAA GACTCATGGA GGAAAGCAGC ACTAACCGAG AGAAATACCT TAAAAGTGTT TTACGGGAAC TGGTCACATA CCTCCTTTTT CTCATAGTCT TGTGCATCTT GACCTACGGC ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA AATGGGAGTT CTAATGTCCA CGTATGA. It is sometimes possible for the material contained within the vial of "PKD2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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