PHF21A cdna clone

PHF21A cDNA Clone

Gene Names

PHF21A; BHC80; BM-006

Synonyms

PHF21A; PHF21A cDNA Clone; PHF21A cdna clone

Ordering
Cat. Num. AAA1275879 For Research Use Only!

Sequence

atggagttgcagactctacaggaggctcttaaagtggaaattcaggttcaccagaaactggttgctcaaatgaagcaggatccacagaatgctgacttaaagaaacagcttcatgaactccaagccaaaatcacagctttgagtgagaaacagaaaagagtagttgaacagctacggaagaacctgatagtaaagcaagaacaaccggacaagttccaaatacagccattgccacaatctgaaaacaaactacaaacagcacagcagcaaccactacagcaactacaacaacagcagcagtaccaccaccaccacgcccagcagtcagctgcagcctctcccaacctgactgcttcacagaagactgtaactacagcttctatgattaccacaaagacactacctctcgtcttgaaagcagcaactgcgaccatgcctgcctctgtggtgggccagagacctaccattgctatggtgaccgccatcaacagtcagaaggctgtgctcagcactgatgtgcagaacacaccagtcaacctccagacgtctagtaaggtcactgggcctggggcagaggctgtccaaattgtggcaaaaaacacagtcactctggttcaggcaacacctcctcagcccatcaaagtaccacagtttatcccccctcctagactcactccacgtccaaactttcttccacaggttcgacccaagcctgtggcccagaataacattcctattgccccagcaccacctcccatgctcgcagctcctcagcttatccagaggcccgtcatgctgaccaagttcacccccacaacccttcccacatcccagaattccatccaccccgtccgtgtcgtcaatgggcagactgcaaccatagccaaaacgttccccatggcccagctcaccagcattgtgatagctactccagggaccagactcgctggacctcaaactgtacagcttagcaagccaagtcttgaaaaacagacagttaaatctcacacagaaacagatgagaaacaaacagagagccgcaccatcaccccacctgctgcacccaaaccaaaacgggaggagaaccctcagaaacttgccttcatggtgtctctagggttggtaacacatgaccatctagaagaaatccaaagcaagaggcaagagcgaaaaagaagaacaacagcaaatccggtctacagtggagcagtctttgagccagagcgtaagaagagtgcagtgacatacctaaacagcacaatgcaccctgggacccggaagagaggtcgtcctccaaaatacaatgcagtgctggggtttggagcccttaccccaacatccccccaatccagtcatcctgactcccctgaaaatgaaaagacagagaccacattcactttccctgcacctgttcagcctgtgtccctgcccagccccacctccacagacggtgatattcatgaggatttttgcagcgtttgcagaaaaagtggccagttactgatgtgcgacacatgttcccgtgtatatcatttggactgcttagacccccctctgaaaacaattcccaagggcatgtggatctgtcccagatgtcaggaccagatgctgaagaaggaagaagcaattccatggcctggaactttagcaattgttcattcctatattgcctacaaagcagcaaaagaagaagagaaacagaagttacttaaatggagttcagatttaaaacaagaacgagaacaactagagcaaaaggtgaaacagctcagcaattccataagtaaatgcatggaaatgaagaacaccatcctggcccggcagaaggagatgcacagctccctggagaaggtaaaacagctgattcgcctcatccacggcatcgacctctccaaacctgtagactctgaggccactgtgggggccatctccaatggcccggactgcaccccccctgccaatgccgccacctccacgccggccccttccccctcctcccagagctgcacagcgaactgtaaccagggggaagagactaaataa

Sequence Length

2043

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

NCBI and Uniprot Product Information

NCBI GI #

34190461

NCBI GeneID

51317

Molecular Weight

74,982 Da

NCBI Official Full Name

Homo sapiens PHD finger protein 21A, mRNA

NCBI Official Synonym Full Names

PHD finger protein 21A

NCBI Official Symbol

PHF21A

NCBI Official Synonym Symbols

BHC80; BM-006

NCBI Protein Information

PHD finger protein 21A

UniProt Protein Name

PHD finger protein 21A

Protein Family

PHD finger protein

UniProt Gene Name

PHF21A

UniProt Synonym Gene Names

BHC80; KIAA1696

UniProt Entry Name

PF21A_HUMAN

NCBI Description

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]

Uniprot Description

PHF21A: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: histone deacetylase complex; nucleoplasm

Molecular Function: chromatin binding; histone binding; histone deacetylase activity; protein binding; transcription cofactor activity

Biological Process: blood coagulation

Research Articles on PHF21A

1. we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2.

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Product Notes

The PHF21A phf21a (Catalog #AAA1275879) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagttgc agactctaca ggaggctctt aaagtggaaa ttcaggttca ccagaaactg gttgctcaaa tgaagcagga tccacagaat gctgacttaa agaaacagct tcatgaactc caagccaaaa tcacagcttt gagtgagaaa cagaaaagag tagttgaaca gctacggaag aacctgatag taaagcaaga acaaccggac aagttccaaa tacagccatt gccacaatct gaaaacaaac tacaaacagc acagcagcaa ccactacagc aactacaaca acagcagcag taccaccacc accacgccca gcagtcagct gcagcctctc ccaacctgac tgcttcacag aagactgtaa ctacagcttc tatgattacc acaaagacac tacctctcgt cttgaaagca gcaactgcga ccatgcctgc ctctgtggtg ggccagagac ctaccattgc tatggtgacc gccatcaaca gtcagaaggc tgtgctcagc actgatgtgc agaacacacc agtcaacctc cagacgtcta gtaaggtcac tgggcctggg gcagaggctg tccaaattgt ggcaaaaaac acagtcactc tggttcaggc aacacctcct cagcccatca aagtaccaca gtttatcccc cctcctagac tcactccacg tccaaacttt cttccacagg ttcgacccaa gcctgtggcc cagaataaca ttcctattgc cccagcacca cctcccatgc tcgcagctcc tcagcttatc cagaggcccg tcatgctgac caagttcacc cccacaaccc ttcccacatc ccagaattcc atccaccccg tccgtgtcgt caatgggcag actgcaacca tagccaaaac gttccccatg gcccagctca ccagcattgt gatagctact ccagggacca gactcgctgg acctcaaact gtacagctta gcaagccaag tcttgaaaaa cagacagtta aatctcacac agaaacagat gagaaacaaa cagagagccg caccatcacc ccacctgctg cacccaaacc aaaacgggag gagaaccctc agaaacttgc cttcatggtg tctctagggt tggtaacaca tgaccatcta gaagaaatcc aaagcaagag gcaagagcga aaaagaagaa caacagcaaa tccggtctac agtggagcag tctttgagcc agagcgtaag aagagtgcag tgacatacct aaacagcaca atgcaccctg ggacccggaa gagaggtcgt cctccaaaat acaatgcagt gctggggttt ggagccctta ccccaacatc cccccaatcc agtcatcctg actcccctga aaatgaaaag acagagacca cattcacttt ccctgcacct gttcagcctg tgtccctgcc cagccccacc tccacagacg gtgatattca tgaggatttt tgcagcgttt gcagaaaaag tggccagtta ctgatgtgcg acacatgttc ccgtgtatat catttggact gcttagaccc ccctctgaaa acaattccca agggcatgtg gatctgtccc agatgtcagg accagatgct gaagaaggaa gaagcaattc catggcctgg aactttagca attgttcatt cctatattgc ctacaaagca gcaaaagaag aagagaaaca gaagttactt aaatggagtt cagatttaaa acaagaacga gaacaactag agcaaaaggt gaaacagctc agcaattcca taagtaaatg catggaaatg aagaacacca tcctggcccg gcagaaggag atgcacagct ccctggagaa ggtaaaacag ctgattcgcc tcatccacgg catcgacctc tccaaacctg tagactctga ggccactgtg ggggccatct ccaatggccc ggactgcacc ccccctgcca atgccgccac ctccacgccg gccccttccc cctcctccca gagctgcaca gcgaactgta accaggggga agagactaaa taa. It is sometimes possible for the material contained within the vial of "PHF21A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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PHF21A cdna clone