PDLIM7 cdna clone
PDLIM7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Description
PDLIM7: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation e.g (embryonic flat bones mandible and cranium), and endochondral bone formation e.g (embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: actin cytoskeleton; focal adhesion; intercellular junction; nucleus
Molecular Function: protein binding
Biological Process: receptor-mediated endocytosis
Research Articles on PDLIM7
Similar Products
Product Notes
The PDLIM7 pdlim7 (Catalog #AAA1269183) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggattcct tcaaagtagt gctggagggg ccagcacctt ggggcttccg gctgcaaggg ggcaaggact tcaatgtgcc cctctccatt tcccggctca ctcctggggg caaagcggcg caggccggag tggccgtggg tgactgggtg ctgagcatcg atggcgagaa tgcgggtagc ctcacacaca tcgaagctca gaacaagatc cgggcctgcg gggagcgcct cagcctgggc ctcagcaggg cccagccggt tcagagcaaa ccgcagaagg cctccgcccc cgccgcggac cctccgcggt acacctttgc acccagcgtc tccctcaaca agacggcccg gccctttggg gcgcccccgc ccgctgacag cgccccgcag cagaatggac agccgctccg accgctggtc ccagatgcca gcaagcagcg gctgatggag aacacagagg actggcggcc gcggccgggg acaggccagt cgcgttcctt ccgcatcctt gcccacctca caggcaccga gttcatgcaa gacccggatg aggagcacct gaagaaatca agccaggtgc ccaggacaga agccccagcc ccagcctcat ctacacccca ggagccctgg cctggcccta ccgcccccag ccctaccagc cgcccgccct gggctgtgga ccctgcgttt gccgagcgct atgccccgga caaaacgagc acagtgctga cccggcacag ccagccggcc acgcccacgc cgctgcagag ccgcacctcc attgtgcagg cagctgccgg aggggtgcca ggagggggca gcaacaacgg caagactccc gtgtgtcacc agtgccacaa ggtcatccgg ggccgctacc tggtggcgct gggccacgcg taccacccgg aggagtttgt gtgtagccag tgtgggaagg tcctggaaga gggtggcttc tttgaggaga agggcgccat cttctgccca ccatgctatg acgtgcgcta tgcacccagc tgtgccaagt gcaagaagaa gattacaggc gagatcatgc acgccctgaa gatgacctgg cacgtgcact gctttacctg tgctgcctgc aagacgccca tccggaacag ggccttctac atggaggagg gcgtgcccta ttgcgagcga gactatgaga agatgtttgg cacgaaatgc catggctgtg acttcaagat cgacgctggg gaccgcttcc tggaggccct gggcttcagc tggcatgaca cctgcttcgt ctgtgcgata tgtcagatca acctggaagg aaagaccttc tactccaaga aggacaggcc tctctgcaag agccatgcct tctctcatgt gtga. It is sometimes possible for the material contained within the vial of "PDLIM7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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