PDE11A cdna clone
PDE11A cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PDE11A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2). Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome. Belongs to the cyclic nucleotide phosphodiesterase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; EC 3.1.4.35; Mitochondrial; EC 3.1.4.17; Phosphodiesterase
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Disease: Pigmented Nodular Adrenocortical Disease, Primary, 2
Research Articles on PDE11A
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Product Notes
The PDE11A pde11a (Catalog #AAA1275121) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCAGCCT CCCGCCTGGA CTTTGGGGAG GTGGAAACTT TCCTGGACAG GCACCCAGAG TTGTTTGAAG ATTACTTGAT GCGGAAGGGG AAGCAGGAGA TGGTTGAAAA GTGGCTGCAG AGGCACAGTC AGGGTCAGGG GGCTTTAGGT CCAAGGCCCT CTTTGGCTGG TACCAGCAGC TTGGCTCACA GCACCTGCAG AGGTGGCAGC AGCGTTGGTG GTGGCACTGG ACCAAATGGC TCTGCCCACA GCCAGCCCCT TCCCGGTGGC GGGGACTGTG GTGGGGTTCC CTTGAGTCCC AGCTGGGCCG GTGGCAGCAG GGGCGATGGG AACCTGCAGC GGAGAGCTTC TCAGAAAGAG CTAAGGAAGA GTTTTGCCCG CTCCAAGGCC ATCCACGTGA ACAGGACCTA CGATGAACAG GTGACCTCCC GGGCTCAGGA ACCCCTGAGT AGTGTACGAC GGAGGGCACT TCTCCGGAAG GCAAGCTCCC TGCCCCCCAC CACAGCCCAT ATTCTCAGTG CGCTGCTGGA ATCGAGAGTG AATCTGCCTC AGTATCCCCC TACAGCCATC GACTACAAGT GCCATCTGAA AAAGCATAAT GAGCGTCAGT TCTTTCTGGA ATTGGTCAAA GATATCTCCA ATGACCTTGA CCTCACCAGC CTGAGCTACA AGATTCTCAT CTTTGTCTGC CTTATGGTGG ATGCTGACCG CTGCTCTCTT TTCCTGGTGG AAGGGGCAGC TGCTGGCAAG AAGACCTTGG TCTCCAAATT CTTTGATGTG CATGCAGGAA CCCCTCTGCT GCCTTGCAGC AGCACAGAGA ACTCAAATGA GGTGCAGGTC CCCTGGGGCA AAGGTATCAT TGGCTATGTC GGGGAGCATG GAGAAACGGT CAACATTCCT GATGCCTACC AGGATCGACG ATTCAATGAT GAAATCGACA AGCTAACTGG ATACAAGACA AAATCATTAT TGTGCATGCC TATCCGAAGC AGTGATGGTG AGATTATTGG TGTGGCCCAA GCGATAAATA AGATTCCTGA AGGAGCTCCA TTTACTGAAG ATGATGAAAA AGTTATGCAG ATGTATCTTC CATTTTGTGG AATCGCCATA TCTAACGCTC AGCTCTTTGC TGCCTCAAGG AAAGAATATG AAAGAAGCAG AGCTTTGCTA GAGGTGGTTA ATGACCTCTT TGAAGAACAG ACTGACCTGG AGAAAATTGT CAAGAAAATA ATGCATCGGG CCCAAACTCT GCTGAAATGT GAACGCTGTT CTGTTTTACT CCTAGAGGAC ATCGAATCAC CAGTGGTGAA ATTTACCAAA TCCTTTGAAT TGATGTCCCC AAAGTGCAGT GCTGATGCTG AGAACAGTTT CAAAGAAAGC ATGGAGAAAT CATCATACTC CGACTGGCTA ATAAATAACA GCATTGCTGA GCTGGTTGCT TCAACAGGCC TTCCAGTGAA CATCAGTGAT GCCTACCAGG ATCCGCGCTT TGATGCAGAG GCAGACCAGA TATCTGGTTT TCACATAAGA TCTGTTCTTT GTGTCCCTAT TTGGAATAGC AACCACCAAA TAATTGGAGT GGCTCAAGTG TTAAACAGAC TTGATGGGAA ACCTTTTGAT GATGCAGATC AACGACTTTT TGAGGCTTTT GTCATCTTTT GTGGACTTGG CATCAACAAC ACAATTATGT ATGATCAAGT GAAGAAGTCC TGGGCCAAGC AGTCTGTGGC TCTTGATGTG CTATCATACC ATGCAACATG TTCAAAAGCT GAAGTTGACA AGTTTAAGGC AGCCAACATC CCTCTGGTGT CAGAACTTGC CATCGATGAC ATTCATTTTG ATGACTTTTC TCTCGACGTT GATGCCATGA TCACAGCTGC TCTCCGGATG TTCATGGAGC TGGGGATGGT ACAGAAATTT AAAATTGACT ATGAGACACT GTGTAGGTGG CTTTTGACAG TGAGGAAAAA CTATCGGATG GTTCTATACC ACAACTGGAG ACATGCCTTC AACGTGTGTC AGCTGATGTT CGCGATGTTA ACCACTGCTG GGTTTCAAGA CATTCTGACC GAGGTGGAAA TTTTAGCGGT GATTGTGGGA TGCCTGTGTC ATGACCTCGA CCACAGGGGA ACCAACAATG CCTTCCAAGC TAAGAGTGGC TCTGCCCTGG CCCAACTCTA TGGAACCTCT GCTACCTTGG AGCATCACCA TTTCAACCAC GCCGTGATGA TCCTTCAAAG TGAGGGTCAC AATATCTTTG CTAACCTGTC CTCCAAGGAA TATAGTGACC TTATGCAGCT TTTGAAGCAG TCAATATTGG CAACAGACCT CACGCTGTAC TTTGAGAGGA GAACTGAATT CTTTGAACTT GTCAGTAAAG GAGAATACGA TTGGAACATC AAAAACCATC GTGATATATT TCGATCAATG TTAATGACAG CCTGTGACCT TGGAGCCGTG ACCAAACCGT GGGAGATCTC CAGACAGGTG GCAGAACTTG TAACCAGTGA GTTCTTCGAA CAAGGAGATC GGGAGAGATT AGAGCTCAAA CTCACTCCTT CAGCAATTTT TGATCGGAAC CGGAAGGATG AACTGCCTCG GTTGCAACTG GAGTGGATTG ATAGCATCTG CATGCCTTTG TATCAGGCAC TGGTGAAGGT CAACGTGAAA CTGAAGCCGA TGCTAGATTC AGTAGCTACA AACAGAAGTA AGTGGGAAGA GCTACACCAA AAACGACTGC TGGCCTCAAC TGCCTCATCC TCCTCCCCTG CCAGTGTTAT GGTAGCCAAG GAAGACAGGA ACTAA. It is sometimes possible for the material contained within the vial of "PDE11A, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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