NR2C1 cdna clone
NR2C1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: nucleoplasm
Molecular Function: DNA binding; protein binding; receptor activity
Biological Process: transcription initiation from RNA polymerase II promoter
Research Articles on NR2C1
Similar Products
Product Notes
The NR2C1 nr2c1 (Catalog #AAA1269520) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaacca tagaagaaat tgcacatcaa attattgaac aacagatggg agagattgtt acagagcagc aaactgggca gaaaatccag attgtgacag cacttgatca taatacccaa ggcaagcagt tcattctgac aaatcacgac ggctctactc caagcaaagt cattctggcc aggcaagatt ccactccggg aaaagttttc cttacaactc cagatgcagc aggtgtcaac cagttatttt ttaccactcc tgatctgtct gcacaacacc tgcagctcct aacagataat tctccagacc aaggaccaaa taaggttttt gatctttgcg tagtatgtgg agacaaagca tcaggacgtc attatggagc agtaacttgt gaaggctgca aaggattttt taaaagaagc atccgaaaaa atttagtata ttcatgtcga ggatcaaagg attgtattat taataagcac caccgaaacc gctgtcaata ctgcaggtta cagagatgta ttgcgtttgg aatgaagcaa gactctgtcc aatgtgaaag aaaacccatt gaagtatcac gagaaaaatc ttccaactgt gccgcttcaa cagaaaaaat ctatatccga aaggaccttc gtagcccatt aactgcaact ccaacttttg taacagatag tgaaagtaca aggtcaacag gactgttaga ttcaggaatg ttcatgaata ttcatccatc tggagtaaaa actgagtcag ctgtgctgat gacatcagat aaggctgaat catgtcaggg agatttaagt acattggcca atgtggttac atcattagcg aatcttggaa aaactaaaga tctttctcaa aatagtaatg aaatgtctat gattgaaagc ttaagcaatg atgatacctc tttgtgtgaa tttcaagaaa tgcagaccaa cggtgatgtt tcaagggcat ttgacactct tgcaaaagca ttgaatcctg gagagagcac agcctgccag agctcagtag cgggcatgga aggaagtgta cacctaatca ctggagattc aagcataaat tacaccgaaa aagaggggcc acttctcagc gattcacatg tagctttcag gctcaccatg ccttctccta tgcctgagta cctgaatgtg cactacattg gggagtctgc ctccagactg ctgttcttat caatgcactg ggcactttcg attccttctt tccaggctct agggcaagaa aacagcatat cactggtgaa agcttactgg aatgaacttt ttactcttgg tcttgcccag tgctggcaag tgatgaatgt agcaactata ttagcaacat ttgtcaattg tcttcacaat agtcttcaac aagcagaggg gtaa. It is sometimes possible for the material contained within the vial of "NR2C1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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