NLRP7 cdna clone

NLRP7 cDNA Clone

Gene Names

NLRP7; HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4

Synonyms

NLRP7; NLRP7 cDNA Clone; NLRP7 cdna clone

Ordering
Cat. Num. AAA1268105 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Sequence

ATGACATCGCCCCAGCTAGAGTGGACTCTGCAGACCCTTCTGGAGCAGCTGAACGAGGATGAATTAAAGAGTTTCAAATCCCTTTTATGGGCTTTTCCCCTCGAAGACGTGCTACAGAAGACCCCATGGTCTGAGGTGGAAGAGGCTGATGGCAAGAAACTGGCAGAAATTCTGGTCAACACCTCCTCAGAAAATTGGATAAGGAATGCGACTGTGAACATCTTGGAAGAGATGAATCTCACGGAATTGTGTAAGATGGCAAAGGCTGAGATGATGGAGGACGGACAGGTGCAAGAAATAGATAATCCTGAGCTGGGAGATGCAGAAGAAGACTCGGAGTTAGCAAAGCCAGGTGAAAAGGAAGGATGGAGAAATTCAATGGAGAAACAATCTTTGGTCTGGAAGAACACCTTTTGGCAAGGAGACATTGACAATTTCCATGACGACGTCACTCTGAGAAACCAACGGTTCATTCCATTCTTGAATCCCAGAACACCCAGGAAGCTAACACCTTACACGGTGGTGCTGCACGGCCCCGCAGGCGTGGGGAAAACCACGCTGGCCAAAAAGTGTATGCTGGACTGGACAGACTGCAACCTCAGCCCGACGCTCAGATACGCGTTCTACCTCAGCTGCAAGGAGCTCAGCCGCATGGGCCCCTGCAGTTTTGCAGAGCTGATCTCCAAAGACTGGCCTGAATTGCAGGATGACATTCCAAGCATCCTAGCCCAAGCACAGAGAATCCTGTTCGTGGTCGATGGCCTTGATGAGCTGAAAGTCCCACCTGGGGCGCTGATCCAGGACATCTGCGGGGACTGGGAGAAGAAGAAGCCGGTGCCCGTCCTCCTGGGGAGTTTGCTGAAGAGGAAGATGTTACCCAGGGCAGCCTTGCTGGTCACCACGCGGCCCAGGGCACTGAGGGACCTCCGGATCCTGGCGCAGCAGCCGATCTACGTAAGGGTGGAGGGCTTCCTGGAGGAGGACAGGAGGGCCTATTTCCTGAGACACTTTGGAGACGAGGACCAAGCCATGCGTGCCTTTGAGCTAATGAGGAGCAACGCGGCCCTGTTCCAGCTGGGCTCGGCCCCCGCGGTGTGCTGGATTGTGTGCACGACTCTGAAGCTGCAGATGGAGAAGGGGGAGGACCCGGTCCCCACCTGCCTCACCCGCACGGGGCTGTTCCTGCGTTTCCTCTGCAGCCGGTTCCCGCAGGGCGCACAGCTGCGGGGCGCGCTGCGGACGCTGAGCCTCCTGGCCGCGCAGGGCCTGTGGGCGCAGATGTCCGTGTTCCACCGAGAGGACCTGGAAAGGCTCGGGGTGCAGGAGTCCGACCTCCGTCTGTTCCTGGACGGAGACATCCTCCGCCAGGACAGAGTCTCCAAAGGCTGCTACTCCTTCATCCACCTCAGCTTCCAGCAGTTTCTCACTGCCCTGTTCTACACCCTGGAGAAGGAGGAGGGGGAGGACAGGGACGGCCACGCCTGGGACATCGGGGACGTACAGAAGCTGCTTTCCGGAGAAGAAAGACTCAAGAACCCCGACCTGATTCAAGTAGGACACTTCTTATTCGGCCTCGCTAACGAGAAGAGAGCCAAGGAGTTGGAGGCCACTTTTGGCTGCCGGATGTCACCGGACATCAAACAGGAATTGCTGCAATGCAAAGCACATCTTCATGCAAATAAGCCCTTATCCGTGACCGACCTGAAGGAGGTCTTGGGCTGCCTGTATGAGTCTCAGGAGGAGGAGCTGGCGAAGGTGGTGGTGGCCCCGTTCAAGGAAATTTCTATTCACCTGACAAATACTTCTGAAGTGATGCATTGTTCCTTCAGCCTGAAGCATTGTCAAGACTTGCAGAAACTCTCACTGCAGGTAGCAAAGGGGGTGTTCCTGGAGAATTACATGGATTTTGAACTGGACATTGAATTTGAAAGGTGCACTTACCTAACCATTCCGAACTGGGCTCGGCAGGATCTTCGCTCTCTTCGCCTCTGGACAGATTTCTGCTCTCTCTTCAGCTCAAACAGCAACCTCAAGTTTCTGGAAGTGAAACAAAGCTTCCTGAGTGACTCTTCTGTGCGGATTCTTTGTGACCACGTAACCCGTAGCACCTGTCATCTGCAGAAAGTGGAGATTAAAAACGTCACCCCTGACACCGCGTACCGGGACTTCTGTCTTGCTTTCATTGGGAAGAAGACCCTCACGCACCTGACCCTGGCAGGGCACATCGAGTGGGAACGCACGATGATGCTGATGCTGTGTGACCTGCTCAGAAATCATAAATGCAACCTGCAGTACCTGAGGTTGGGAGGTCACTGTGCCACCCCGGAGCAGTGGGCTGAATTCTTCTATGTCCTCAAAGCCAACCAGTCCCTGAAGCACCTGCGTCTCTCAGCCAATGTGCTCCTGGATGAGGGTGCCATGTTGCTGTACAAGACCATGACACGCCCAAAACACTTCCTGCAGATGTTGTCGTTGGAAAACTGTCGTCTTACAGAAGCCAGTTGCAAGGACCTTGCTGCTGTCTTGGTTGTCAGCAAGAAGCTGACACACCTGTGCTTGGCCAAGAACCCCATTGGGGATACAGGGGTGAAGTTTCTGTGTGAGGGCTTGAGTTACCCTGATTGTAAACTGCAGACCTTGGTGTTACAGCAATGCAGCATAACCAAGCTTGGCTGTAGATACCTCTCAGAGGCGCTCCAAGAAGCCTGCAGCCTCACAAACCTGGACTTGAGTATCAACCAGATAGCTCGTGGATTGTGGATTCTCTGTCAGGCGTTAGAGAATCCAAACTGTAACCTAAAACACCTACGCCTCTGGAGCTGCTCCCTCATGCCTTTCTATTGTCAGCATCTTGGATCTGCTCTCCTCAGCAATCAGAAGCTTGAAACTCTGGACCTGGGCCAGAATCATTTGTGGAAGAGTGGCATAATTAAGCTCTTTGGGGTTCTAAGACAAAGAACTGGATCCTTGAAGATACTCAGGTTGAAGACCTATGAAACTAATTTGGAAATCAAGAAGCTGTTGGAGGAAGTGAAAGAAAAGAATCCCAAGCTGACTATTGATTGCAATGCTTCCGGGGCAACGGCACCTCCGTGCTGTGACTTTTTTTGCTGA

Sequence Length

3114

Vector

Please Inquire

NCBI and Uniprot Product Information

NCBI GI #

80476619

NCBI GeneID

199713

Molecular Weight

118,303 Da

NCBI Official Full Name

Homo sapiens NLR family, pyrin domain containing 7, mRNA

NCBI Official Synonym Full Names

NLR family pyrin domain containing 7

NCBI Official Symbol

NLRP7

NCBI Official Synonym Symbols

HYDM; PAN7; NALP7; NOD12; PYPAF3; CLR19.4

NCBI Protein Information

NACHT, LRR and PYD domains-containing protein 7

UniProt Protein Name

NACHT, LRR and PYD domains-containing protein 7

Protein Family

NACHT, LRR and PYD domains-containing protein

UniProt Gene Name

NLRP7

UniProt Synonym Gene Names

NALP7; NOD12; PYPAF3

UniProt Entry Name

NALP7_HUMAN

NCBI Description

This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

NLRP7: Inhibits CASP1/caspase-1-dependent IL1B secretion. Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 (HYDM1). A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 19q13.42

Disease: Hydatidiform Mole, Recurrent, 1

Research Articles on NLRP7

1. the NLRP7 inflammasome contributes to IL-1beta secretion and induction of pyroptosis in response to M. bovis infection in THP-1 macrophages.

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Product Notes

The NLRP7 nlrp7 (Catalog #AAA1268105) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACATCGC CCCAGCTAGA GTGGACTCTG CAGACCCTTC TGGAGCAGCT GAACGAGGAT GAATTAAAGA GTTTCAAATC CCTTTTATGG GCTTTTCCCC TCGAAGACGT GCTACAGAAG ACCCCATGGT CTGAGGTGGA AGAGGCTGAT GGCAAGAAAC TGGCAGAAAT TCTGGTCAAC ACCTCCTCAG AAAATTGGAT AAGGAATGCG ACTGTGAACA TCTTGGAAGA GATGAATCTC ACGGAATTGT GTAAGATGGC AAAGGCTGAG ATGATGGAGG ACGGACAGGT GCAAGAAATA GATAATCCTG AGCTGGGAGA TGCAGAAGAA GACTCGGAGT TAGCAAAGCC AGGTGAAAAG GAAGGATGGA GAAATTCAAT GGAGAAACAA TCTTTGGTCT GGAAGAACAC CTTTTGGCAA GGAGACATTG ACAATTTCCA TGACGACGTC ACTCTGAGAA ACCAACGGTT CATTCCATTC TTGAATCCCA GAACACCCAG GAAGCTAACA CCTTACACGG TGGTGCTGCA CGGCCCCGCA GGCGTGGGGA AAACCACGCT GGCCAAAAAG TGTATGCTGG ACTGGACAGA CTGCAACCTC AGCCCGACGC TCAGATACGC GTTCTACCTC AGCTGCAAGG AGCTCAGCCG CATGGGCCCC TGCAGTTTTG CAGAGCTGAT CTCCAAAGAC TGGCCTGAAT TGCAGGATGA CATTCCAAGC ATCCTAGCCC AAGCACAGAG AATCCTGTTC GTGGTCGATG GCCTTGATGA GCTGAAAGTC CCACCTGGGG CGCTGATCCA GGACATCTGC GGGGACTGGG AGAAGAAGAA GCCGGTGCCC GTCCTCCTGG GGAGTTTGCT GAAGAGGAAG ATGTTACCCA GGGCAGCCTT GCTGGTCACC ACGCGGCCCA GGGCACTGAG GGACCTCCGG ATCCTGGCGC AGCAGCCGAT CTACGTAAGG GTGGAGGGCT TCCTGGAGGA GGACAGGAGG GCCTATTTCC TGAGACACTT TGGAGACGAG GACCAAGCCA TGCGTGCCTT TGAGCTAATG AGGAGCAACG CGGCCCTGTT CCAGCTGGGC TCGGCCCCCG CGGTGTGCTG GATTGTGTGC ACGACTCTGA AGCTGCAGAT GGAGAAGGGG GAGGACCCGG TCCCCACCTG CCTCACCCGC ACGGGGCTGT TCCTGCGTTT CCTCTGCAGC CGGTTCCCGC AGGGCGCACA GCTGCGGGGC GCGCTGCGGA CGCTGAGCCT CCTGGCCGCG CAGGGCCTGT GGGCGCAGAT GTCCGTGTTC CACCGAGAGG ACCTGGAAAG GCTCGGGGTG CAGGAGTCCG ACCTCCGTCT GTTCCTGGAC GGAGACATCC TCCGCCAGGA CAGAGTCTCC AAAGGCTGCT ACTCCTTCAT CCACCTCAGC TTCCAGCAGT TTCTCACTGC CCTGTTCTAC ACCCTGGAGA AGGAGGAGGG GGAGGACAGG GACGGCCACG CCTGGGACAT CGGGGACGTA CAGAAGCTGC TTTCCGGAGA AGAAAGACTC AAGAACCCCG ACCTGATTCA AGTAGGACAC TTCTTATTCG GCCTCGCTAA CGAGAAGAGA GCCAAGGAGT TGGAGGCCAC TTTTGGCTGC CGGATGTCAC CGGACATCAA ACAGGAATTG CTGCAATGCA AAGCACATCT TCATGCAAAT AAGCCCTTAT CCGTGACCGA CCTGAAGGAG GTCTTGGGCT GCCTGTATGA GTCTCAGGAG GAGGAGCTGG CGAAGGTGGT GGTGGCCCCG TTCAAGGAAA TTTCTATTCA CCTGACAAAT ACTTCTGAAG TGATGCATTG TTCCTTCAGC CTGAAGCATT GTCAAGACTT GCAGAAACTC TCACTGCAGG TAGCAAAGGG GGTGTTCCTG GAGAATTACA TGGATTTTGA ACTGGACATT GAATTTGAAA GGTGCACTTA CCTAACCATT CCGAACTGGG CTCGGCAGGA TCTTCGCTCT CTTCGCCTCT GGACAGATTT CTGCTCTCTC TTCAGCTCAA ACAGCAACCT CAAGTTTCTG GAAGTGAAAC AAAGCTTCCT GAGTGACTCT TCTGTGCGGA TTCTTTGTGA CCACGTAACC CGTAGCACCT GTCATCTGCA GAAAGTGGAG ATTAAAAACG TCACCCCTGA CACCGCGTAC CGGGACTTCT GTCTTGCTTT CATTGGGAAG AAGACCCTCA CGCACCTGAC CCTGGCAGGG CACATCGAGT GGGAACGCAC GATGATGCTG ATGCTGTGTG ACCTGCTCAG AAATCATAAA TGCAACCTGC AGTACCTGAG GTTGGGAGGT CACTGTGCCA CCCCGGAGCA GTGGGCTGAA TTCTTCTATG TCCTCAAAGC CAACCAGTCC CTGAAGCACC TGCGTCTCTC AGCCAATGTG CTCCTGGATG AGGGTGCCAT GTTGCTGTAC AAGACCATGA CACGCCCAAA ACACTTCCTG CAGATGTTGT CGTTGGAAAA CTGTCGTCTT ACAGAAGCCA GTTGCAAGGA CCTTGCTGCT GTCTTGGTTG TCAGCAAGAA GCTGACACAC CTGTGCTTGG CCAAGAACCC CATTGGGGAT ACAGGGGTGA AGTTTCTGTG TGAGGGCTTG AGTTACCCTG ATTGTAAACT GCAGACCTTG GTGTTACAGC AATGCAGCAT AACCAAGCTT GGCTGTAGAT ACCTCTCAGA GGCGCTCCAA GAAGCCTGCA GCCTCACAAA CCTGGACTTG AGTATCAACC AGATAGCTCG TGGATTGTGG ATTCTCTGTC AGGCGTTAGA GAATCCAAAC TGTAACCTAA AACACCTACG CCTCTGGAGC TGCTCCCTCA TGCCTTTCTA TTGTCAGCAT CTTGGATCTG CTCTCCTCAG CAATCAGAAG CTTGAAACTC TGGACCTGGG CCAGAATCAT TTGTGGAAGA GTGGCATAAT TAAGCTCTTT GGGGTTCTAA GACAAAGAAC TGGATCCTTG AAGATACTCA GGTTGAAGAC CTATGAAACT AATTTGGAAA TCAAGAAGCT GTTGGAGGAA GTGAAAGAAA AGAATCCCAA GCTGACTATT GATTGCAATG CTTCCGGGGC AACGGCACCT CCGTGCTGTG ACTTTTTTTG CTGA. It is sometimes possible for the material contained within the vial of "NLRP7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

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