NET1 cdna clone
NET1 cDNA Clone
Gene Names
NET1; NET1A; ARHGEF8
Synonyms
NET1; NET1 cDNA Clone; NET1 cdna clone
Sequence
atggagcccgagctggcggctcagaagcagcctcgaccgcggaggcgaagccgccgggcctctgggctcagcacggagggagcgacggggccttcggccgacacctccgggtcggagctggacgggagatgttcccttcggagaggcagctccttcacattcttaacacctggccccaactgggacttcactttgaaaagaaaacgcagagagaaagatgatgatgttgtaagccttagcagccttgatctgaaggagccaagcaataaaagagttcgacctctggctcgtgtcacgtccttggcaaatttaatctctcctgtaagaaatggagctgtcagacgttttggtcaaacaatacagtcatttacccttcgtggtgaccacagatccccagcctctgcccagaagttttctagcaggtcaacagtcccaacacccgccaagagaaggagcagtgcactgtggtcagagatgctggacatcaccatgaaggagtctctcaccaccagggagatcagacggcaggaggcaatatatgaaatgtcccgaggtgaacaggatttaattgaggatctcaaacttgcaagaaaggcctaccatgaccccatgttaaagttgtccatcatgtcagaagaggaactcacacatatatttggtgatctggactcttacatacctctgcatgaagatttgttgacaagaataggagaagcaaccaagcctgatggaacagtggagcagattggtcacattctcgtgagctggttaccgcgcttgaatgcctacagaggttactgtagtaaccagctggcagccaaagctcttcttgatcaaaagaaacaggatccaagagtccaagacttcctccagcgatgtctcgagtctcccttcagtcgaaaactagatctttggagtttcctagatatccctcgaagtcgcctagtcaaataccctttactgttaaaagaaattcttaaacacactccaaaagagcaccctgatgttcagcttctggaggatgctatattgataatacagggagtcctctctgatatcaacttgaagaaaggtgaatccgagtgccagtattacatcgacaagctggagtacctggatgaaaagcagagggaccccagaatcgaagcgagcaaagtgctgctgtgccatggggagctgcggagcaagagtggacataaactttacattttcctgtttcaagacatcttggttctgactcggcccgtcacacggaacgaacggcactcttaccaggtttaccggcagccaatcccagtccaagagctagtcctagaagacctgcaggatggagatgtgagaatgggaggctcctttcgaggagctttcagtaactcagagaaagctaaaaatatctttagaattcgcttccatgacccctctccagcccagtctcacactctgcaagccaatgacgtgttccacaagcagcagtggttcaactgtattcgagcggccattgcccccttccagtcggcaggcagtccacctgagctgcagggcctgccggagctgcacgaagagtgtgaggggaaccacccctctgcgaggaaactcacagcccagaggagggcatccacagtttccagtgttactcaggtagaagttgatgaaaacgcttacagatgtggctctggcatgcagatggcagaggacagcaagagcttaaagacacaccagacacagcccggcatccgaagagcgagggacaaagccctttctggtggcaaacggaaagagactttggtgtag
Sequence Length
1791
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
61,885 Da
NCBI Official Full Name
Homo sapiens neuroepithelial cell transforming 1, mRNA
NCBI Official Synonym Full Names
neuroepithelial cell transforming 1
NCBI Official Symbol
NET1
NCBI Official Synonym Symbols
NET1A; ARHGEF8
NCBI Protein Information
neuroepithelial cell-transforming gene 1 protein
UniProt Protein Name
Neuroepithelial cell-transforming gene 1 protein
Protein Family
UniProt Gene Name
NET1
UniProt Synonym Gene Names
ARHGEF8
UniProt Entry Name
ARHG8_HUMAN
NCBI Description
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
NET1: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on NET1
Similar Products
Product Notes
The NET1 net1 (Catalog #AAA1274638) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagcccg agctggcggc tcagaagcag cctcgaccgc ggaggcgaag ccgccgggcc tctgggctca gcacggaggg agcgacgggg ccttcggccg acacctccgg gtcggagctg gacgggagat gttcccttcg gagaggcagc tccttcacat tcttaacacc tggccccaac tgggacttca ctttgaaaag aaaacgcaga gagaaagatg atgatgttgt aagccttagc agccttgatc tgaaggagcc aagcaataaa agagttcgac ctctggctcg tgtcacgtcc ttggcaaatt taatctctcc tgtaagaaat ggagctgtca gacgttttgg tcaaacaata cagtcattta cccttcgtgg tgaccacaga tccccagcct ctgcccagaa gttttctagc aggtcaacag tcccaacacc cgccaagaga aggagcagtg cactgtggtc agagatgctg gacatcacca tgaaggagtc tctcaccacc agggagatca gacggcagga ggcaatatat gaaatgtccc gaggtgaaca ggatttaatt gaggatctca aacttgcaag aaaggcctac catgacccca tgttaaagtt gtccatcatg tcagaagagg aactcacaca tatatttggt gatctggact cttacatacc tctgcatgaa gatttgttga caagaatagg agaagcaacc aagcctgatg gaacagtgga gcagattggt cacattctcg tgagctggtt accgcgcttg aatgcctaca gaggttactg tagtaaccag ctggcagcca aagctcttct tgatcaaaag aaacaggatc caagagtcca agacttcctc cagcgatgtc tcgagtctcc cttcagtcga aaactagatc tttggagttt cctagatatc cctcgaagtc gcctagtcaa atacccttta ctgttaaaag aaattcttaa acacactcca aaagagcacc ctgatgttca gcttctggag gatgctatat tgataataca gggagtcctc tctgatatca acttgaagaa aggtgaatcc gagtgccagt attacatcga caagctggag tacctggatg aaaagcagag ggaccccaga atcgaagcga gcaaagtgct gctgtgccat ggggagctgc ggagcaagag tggacataaa ctttacattt tcctgtttca agacatcttg gttctgactc ggcccgtcac acggaacgaa cggcactctt accaggttta ccggcagcca atcccagtcc aagagctagt cctagaagac ctgcaggatg gagatgtgag aatgggaggc tcctttcgag gagctttcag taactcagag aaagctaaaa atatctttag aattcgcttc catgacccct ctccagccca gtctcacact ctgcaagcca atgacgtgtt ccacaagcag cagtggttca actgtattcg agcggccatt gcccccttcc agtcggcagg cagtccacct gagctgcagg gcctgccgga gctgcacgaa gagtgtgagg ggaaccaccc ctctgcgagg aaactcacag cccagaggag ggcatccaca gtttccagtg ttactcaggt agaagttgat gaaaacgctt acagatgtgg ctctggcatg cagatggcag aggacagcaa gagcttaaag acacaccaga cacagcccgg catccgaaga gcgagggaca aagccctttc tggtggcaaa cggaaagaga ctttggtgta g. It is sometimes possible for the material contained within the vial of "NET1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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