NET1 cdna clone
NET1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
NET1: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs; Oncoprotein
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on NET1
Similar Products
Product Notes
The NET1 net1 (Catalog #AAA1271909) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtggcac atgatgagac tggaggtctc ctacctatta aaaggaccat acgagtccta gatgtcaata accagtcctt cagagaacaa gaggagccaa gcaataaaag agttcgacct ctggctcgtg tcacgtcctt ggcaaattta atctctcctg taagaaatgg agctgtcaga cgttttggtc aaacaataca gtcatttacc cttcgtggtg accacagatc cccagcctct gcccagaagt tttctagcag gtcaacagtc ccaacacccg ccaagagaag gagcagtgca ctgtggtcag agatgctgga catcaccatg aaggagtctc tcaccaccag ggagatcaga cggcaggagg caatatatga aatgtcccga ggtgaacagg atttaattga ggatctcaaa cttgcaagaa aggcctacca tgaccccatg ttaaagttgt ccatcatgtc agaagaggaa ctcacacata tatttggtga tctggactct tacatacctc tgcatgaaga tttgttgaca agaataggag aagcaaccaa gcctgatgga acagtggagc agattggtca cattctcgtg agctggttac cgcgcttgaa tgcctacaga ggttactgta gtaaccagct ggcagccaaa gctcttcttg atcaaaagaa acaggatcca agagtccaag acttcctcca gcgatgtctc gagtctccct tcagtcgaaa actagatctt tggagtttcc tagatatccc tcgaagtcgc ctagtcaaat accctttact gttaaaagaa attcttaaac acactccaaa agagcaccct gatgttcagc ttctggagga tgctatattg ataatacagg gagtcctctc tgatatcaac ttgaagaaag gtgaatccga gtgccagtat tacatcgaca agctggagta cctggatgaa aagcagaggg accccagaat cgaagcgagc aaagtgctgc tgtgccatgg ggagctgcgg agcaagagtg gacataaact ttacattttc ctgtttcaag acatcttggt tctgactcgg cccgtcacac ggaacgaacg gcactcttac caggtttacc ggcagccaat cccagtccaa gagctagtcc tagaagacct gcaggatgga gatgtgagaa tgggaggctc ctttcgagga gctttcagta actcagagaa agctaaaaat atctttagaa ttcgcttcca tgacccctct ccagcccagt ctcacactct gcaagccaat gacgtgttcc acaagcagca gtggttcaac tgtattcgag cggccattgc ccccttccag tcggcaggca gtccacctga gctgcagggc ctgccggagc tgcacgaaga gtgtgagggg aaccacccct ctgcgaggaa actcacagcc cagaggaggg catccacagt ttccagtgtt actcaggtag aagttgatga aaacgcttac agatgtggct ctggcatgca gatggcagag gacagcaaga gcttaaagac acaccagaca cagcccggca tccgaagagc gagggacaaa gccctttctg gtggcaaacg gaaagagact ttggtgtag. It is sometimes possible for the material contained within the vial of "NET1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
