NDUFA13 cdna clone
NDUFA13 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Uniprot Description
GRIM-19: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC). Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms. Belongs to the complex I NDUFA13 subunit family.
Protein type: Membrane protein, integral; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrial membrane; mitochondrial respiratory chain; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm
Molecular Function: NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; protein binding
Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of protein catabolic process; protein import into mitochondrial inner membrane
Disease: Thyroid Carcinoma, Hurthle Cell
Research Articles on NDUFA13
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Product Notes
The NDUFA13 ndufa13 (Catalog #AAA1274459) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcggcgt caaaggtgaa gcaggacatg cctccgccgg ggggctatgg gcccatcgac tacaaacgga acttgccgcg tcgaggactg tcgggctaca gcatgctggc catagggatt ggaaccctga tctacgggca ctggagcata atgaagtgga accgtgagcg caggcgccta caaatcgagg acttcgaggc tcgcatcgcg ctgttgccac tgttacaggc agaaaccgac cggaggacct tgcagatgct tcgggagaac ctggaggagg aggccatcat catgaaggac gtgcccgact ggaaggtggg ggagtctgtg ttccacacaa cccgctgggt gccccccttg atcggggagc tgtacgggct gcgcaccaca gaggaggctc tccatgccag ccacggcttc atgtggtaca cgtag. It is sometimes possible for the material contained within the vial of "NDUFA13, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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