NCOA3 cdna clone
NCOA3 cDNA Clone
Gene Names
NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Synonyms
NCOA3; NCOA3 cDNA Clone; NCOA3 cdna clone
Sequence
ATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAATTTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAATGATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAATATAAGCAAGAGGACCTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATATTCTGGAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGATTTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTTTCAGGAAAGGTTGTCAATATAGATACAAATTCACTGAGATCCTCCATGAGGCCTGGCTTTGAAGATATAATCCGAAGGTGTATTCAGAGATTTTTTAGTCTAAATGATGGGCAGTCATGGTCCCAGAAACGTCACTATCAAGAAGCTTATCTTAATGGCCATGCAGAAACCCCAGTATATCGATTCTCGTTGGCTGATGGAACTATAGTGACTGCACAGACAAAAAGCAAACTCTTCCGAAATCCTGTAACAAATGATCGACATGGCTTTGTCTCAACCCACTTCCTTCAGAGAGAACAGAATGGATATAGACCAAACCCAAATCCTGTTGGACAAGGGATTAGACCACCTATGGCTGGATGCAACAGTTCGGTAGGCGGCATGAGTATGTCGCCAAACCAAGGCTTACAGATGCCGAGCAGCAGGGCCTATGGCTTGGCAGACCCTAGCACCACAGGGCAGATGAGTGGAGCTAGGTATGGGGGTTCCAGTAACATAGCTTCATTGACCCCTGGGCCAGGCATGCAATCACCATCTTCCTACCAGAACAACAACTATGGGCTCAACATGAGTAGCCCCCCACATGGGAGTCCTGGTCTTGCCCCAAACCAGCAGAATATCATGATTTCTCCTCGTAATCGTGGGAGTCCAAAGATAGCCTCACATCAGTTTTCTCCTGTTGCAGGTGTGCACTCTCCCATGGCATCTTCTGGCAATACTGGGAACCACAGCTTTTCCAGCAGCTCTCTCAGTGCCCTGCAAGCCATCAGTGAAGGTGTGGGGACTTCCCTTTTATCTACTCTGTCATCACCAGGCCCCAAATTGGATAACTCTCCCAATATGAATATTACCCAACCAAGTAAAGTAAGCAATCAGGATTCCAAGAGTCCTCTGGGCTTTTATTGCGACCAAAATCCAGTGGAGAGTTCAATGTGTCAGTCAAATAGCAGAGATCACCTCAGTGACAAAGAAAGTAAGGAGAGCAGTGTTGAGGGGGCAGAGAATCAAAGGGGTCCTTTGGAAAGCAAAGGTCATAAAAAATTACTGCAGTTACTTACCTGTTCTTCTGATGACCGGGGTCATTCCTCCTTGACCAACTCCCCCCTAGATTCAAGTTGTAAAGAATCTTCTGTTAGTGTCACCAGCCCCTCTGGAGTCTCCTCCTCTACATCTGGAGGAGTATCCTCTACATCCAATATGCATGGGTCACTGTTACAAGAGAAGCACCGGATTTTGCACAAGTTGCTGCAGAATGGGAATTCACCAGCTGAGGTAGCCAAGATTACTGCAGAAGCCACTGGGAAAGACACCAGCAGTATAACTTCTTGTGGGGACGGAAATGTTGTCAAGCAGGAGCAGCTAAGTCCTAAGAAGAAGGAGAATAATGCACTTCTTAGATACCTGCTGGACAGGGATGATCCTAGTGATGCACTCTCTAAAGAACTACAGCCCCAAGTGGAAGGAGTGGATAATAAAATGAGTCAGTGCACCAGCTCCACCATTCCTAGCTCAAGTCAAGAGAAAGACCCTAAAATTAAGACAGAGACAAGTGAAGAGGGATCTGGAGACTTGGATAATCTAGATGCTATTCTTGGTGATCTGACTAGTTCTGACTTTTACAATAATTCCATATCCTCAAATGGTAGTCATCTGGGGACTAAGCAACAGGTGTTTCAAGGAACTAATTCTCTGGGTTTGAAAAGTTCACAGTCTGTGCAGTCTATTCGTCCTCCATATAACCGAGCAGTGTCTCTGGATAGCCCTGTTTCTGTTGGCTCAAGTCCTCCAGTAAAAAATATCAGTGCTTTCCCCATGTTACCAAAGCAACCCATGTTGGGTGGGAATCCAAGAATGATGGATAGTCAGGAAAATTATGGCTCAAGTATGGGTGGGCCAAACCGAAATGTGACTGTGACTCAGACTCCTTCCTCAGGAGACTGGGGCTTACCAAACTCAAAGGCCGGCAGAATGGAACCTATGAATTCAAACTCCATGGGAAGACCAGGAGGAGATTATAATACTTCTTTACCCAGACCTGCACTGGGTGGCTCTATTCCCACATTGCCTCTTCGGTCTAATAGCATACCAGGTGCGAGACCAGTATTGCAACAGCAGCAGCAGATGCTTCAAATGAGGCCTGGTGAAATCCCCATGGGAATGGGGGCTAATCCCTATGGCCAAGCAGCAGCATCTAACCAACTGGGTTCCTGGCCCGATGGCATGTTGTCCATGGAACAAGTTTCTCATGGCACTCAAAATAGGCCTCTTCTTAGGAATTCCCTGGATGATCTTGTTGGGCCACCTTCCAACCTGGAAGGCCAGAGTGACGAAAGAGCATTATTGGACCAGCTGCACACTCTTCTCAGCAACACAGATGCCACAGGCCTGGAAGAAATTGACAGAGCTTTGGGCATTCCTGAACTTGTCAATCAGGGACAGGCATTAGAGCCCAAACAGGATGCTTTCCAAGGCCAAGAAGCAGCAGTAATGATGGATCAGAAGGCAGGATTATATGGACAGACATACCCAGCACAGGGGCCTCCAATGCAAGGAGGCTTTCATCTTCAGGGACAATCACCATCTTTTAACTCTATGATGAATCAGATGAACCAGCAAGGCAATTTTCCTCTCCAAGGAATGCACCCACGAGCCAACATCATGAGACCCCGGACAAACACCCCCAAGCAACTTAGAATGCAGCTTCAGCAGAGGCTGCAGGGCCAGCAGTTTTTGAATCAGAGCCGACAGGCACTTGAATTGAAAATGGAAAACCCTACTGCTGGTGGTGCTGCGGTGATGAGGCCTATGATGCAGCCCCAGCAGGGTTTTCTTAATGCTCAAATGGTCGCCCAACGCAGCAGAGAGCTGCTAAGTCATCACTTCCGACAACAGAGGGTGGCTATGATGATGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGCAACAGCAGCAAACCCAGGCCTTCAGCCCACCTCCTAATGTGACTGCTTCCCCCAGCATGGATGGGCTTTTGGCAGGACCCACAATGCCACAAGCTCCTCCGCAACAGTTTCCATATCAACCAAATTATGGAATGGGACAACAACCAGATCCAGCCTTTGGTCGAGTGTCTAGTCCTCCCAATGCAATGATGTCGTCAAGAATGGGTCCCTCCCAGAATCCCATGATGCAACACCCGCAGGCTGCATCCATCTATCAGTCCTCAGAAATGAAGGGCTGGCCATCAGGAAATTTGGCCAGGAACAGCTCCTTTTCCCAGCAGCAGTTTGCCCACCAGGGGAATCCTGCAGTGTATAGTATGGTGCACATGAATGGCAGCAGTGGTCACATGGGACAGATGAACATGAACCCCATGCCCATGTCTGGCATGCCTATGGGTCCTGATCAGAAATACTGCTGA
Sequence Length
4263
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
154,892 Da
NCBI Official Full Name
Homo sapiens nuclear receptor coactivator 3, mRNA
NCBI Official Synonym Full Names
nuclear receptor coactivator 3
NCBI Official Symbol
NCOA3
NCBI Official Synonym Symbols
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
NCBI Protein Information
nuclear receptor coactivator 3
UniProt Protein Name
Nuclear receptor coactivator 3
Protein Family
UniProt Gene Name
NCOA3
UniProt Synonym Gene Names
AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1
UniProt Entry Name
NCOA3_HUMAN
NCBI Description
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Uniprot Description
SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.
Protein type: EC 2.3.1.48; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity
Biological Process: intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on NCOA3
Similar Products
Product Notes
The NCOA3 ncoa3 (Catalog #AAA1269963) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGTGGAT TAGGAGAAAA CTTGGATCCA CTGGCCAGTG ATTCACGAAA ACGCAAATTG CCATGTGATA CTCCAGGACA AGGTCTTACC TGCAGTGGTG AAAAACGGAG ACGGGAGCAG GAAAGTAAAT ATATTGAAGA ATTGGCTGAG CTGATATCTG CCAATCTTAG TGATATTGAC AATTTCAATG TCAAACCAGA TAAATGTGCG ATTTTAAAGG AAACAGTAAG ACAGATACGT CAAATAAAAG AGCAAGGAAA AACTATTTCC AATGATGATG ATGTTCAAAA AGCCGATGTA TCTTCTACAG GGCAGGGAGT TATTGATAAA GACTCCTTAG GACCGCTTTT ACTTCAGGCA TTGGATGGTT TCCTATTTGT GGTGAATCGA GACGGAAACA TTGTATTTGT ATCAGAAAAT GTCACACAAT ACCTGCAATA TAAGCAAGAG GACCTGGTTA ACACAAGTGT TTACAATATC TTACATGAAG AAGACAGAAA GGATTTTCTT AAGAATTTAC CAAAATCTAC AGTTAATGGA GTTTCCTGGA CAAATGAGAC CCAAAGACAA AAAAGCCATA CATTTAATTG CCGTATGTTG ATGAAAACAC CACATGATAT TCTGGAAGAC ATAAACGCCA GTCCTGAAAT GCGCCAGAGA TATGAAACAA TGCAGTGCTT TGCCCTGTCT CAGCCACGAG CTATGATGGA GGAAGGGGAA GATTTGCAAT CTTGTATGAT CTGTGTGGCA CGCCGCATTA CTACAGGAGA AAGAACATTT CCATCAAACC CTGAGAGCTT TATTACCAGA CATGATCTTT CAGGAAAGGT TGTCAATATA GATACAAATT CACTGAGATC CTCCATGAGG CCTGGCTTTG AAGATATAAT CCGAAGGTGT ATTCAGAGAT TTTTTAGTCT AAATGATGGG CAGTCATGGT CCCAGAAACG TCACTATCAA GAAGCTTATC TTAATGGCCA TGCAGAAACC CCAGTATATC GATTCTCGTT GGCTGATGGA ACTATAGTGA CTGCACAGAC AAAAAGCAAA CTCTTCCGAA ATCCTGTAAC AAATGATCGA CATGGCTTTG TCTCAACCCA CTTCCTTCAG AGAGAACAGA ATGGATATAG ACCAAACCCA AATCCTGTTG GACAAGGGAT TAGACCACCT ATGGCTGGAT GCAACAGTTC GGTAGGCGGC ATGAGTATGT CGCCAAACCA AGGCTTACAG ATGCCGAGCA GCAGGGCCTA TGGCTTGGCA GACCCTAGCA CCACAGGGCA GATGAGTGGA GCTAGGTATG GGGGTTCCAG TAACATAGCT TCATTGACCC CTGGGCCAGG CATGCAATCA CCATCTTCCT ACCAGAACAA CAACTATGGG CTCAACATGA GTAGCCCCCC ACATGGGAGT CCTGGTCTTG CCCCAAACCA GCAGAATATC ATGATTTCTC CTCGTAATCG TGGGAGTCCA AAGATAGCCT CACATCAGTT TTCTCCTGTT GCAGGTGTGC ACTCTCCCAT GGCATCTTCT GGCAATACTG GGAACCACAG CTTTTCCAGC AGCTCTCTCA GTGCCCTGCA AGCCATCAGT GAAGGTGTGG GGACTTCCCT TTTATCTACT CTGTCATCAC CAGGCCCCAA ATTGGATAAC TCTCCCAATA TGAATATTAC CCAACCAAGT AAAGTAAGCA ATCAGGATTC CAAGAGTCCT CTGGGCTTTT ATTGCGACCA AAATCCAGTG GAGAGTTCAA TGTGTCAGTC AAATAGCAGA GATCACCTCA GTGACAAAGA AAGTAAGGAG AGCAGTGTTG AGGGGGCAGA GAATCAAAGG GGTCCTTTGG AAAGCAAAGG TCATAAAAAA TTACTGCAGT TACTTACCTG TTCTTCTGAT GACCGGGGTC ATTCCTCCTT GACCAACTCC CCCCTAGATT CAAGTTGTAA AGAATCTTCT GTTAGTGTCA CCAGCCCCTC TGGAGTCTCC TCCTCTACAT CTGGAGGAGT ATCCTCTACA TCCAATATGC ATGGGTCACT GTTACAAGAG AAGCACCGGA TTTTGCACAA GTTGCTGCAG AATGGGAATT CACCAGCTGA GGTAGCCAAG ATTACTGCAG AAGCCACTGG GAAAGACACC AGCAGTATAA CTTCTTGTGG GGACGGAAAT GTTGTCAAGC AGGAGCAGCT AAGTCCTAAG AAGAAGGAGA ATAATGCACT TCTTAGATAC CTGCTGGACA GGGATGATCC TAGTGATGCA CTCTCTAAAG AACTACAGCC CCAAGTGGAA GGAGTGGATA ATAAAATGAG TCAGTGCACC AGCTCCACCA TTCCTAGCTC AAGTCAAGAG AAAGACCCTA AAATTAAGAC AGAGACAAGT GAAGAGGGAT CTGGAGACTT GGATAATCTA GATGCTATTC TTGGTGATCT GACTAGTTCT GACTTTTACA ATAATTCCAT ATCCTCAAAT GGTAGTCATC TGGGGACTAA GCAACAGGTG TTTCAAGGAA CTAATTCTCT GGGTTTGAAA AGTTCACAGT CTGTGCAGTC TATTCGTCCT CCATATAACC GAGCAGTGTC TCTGGATAGC CCTGTTTCTG TTGGCTCAAG TCCTCCAGTA AAAAATATCA GTGCTTTCCC CATGTTACCA AAGCAACCCA TGTTGGGTGG GAATCCAAGA ATGATGGATA GTCAGGAAAA TTATGGCTCA AGTATGGGTG GGCCAAACCG AAATGTGACT GTGACTCAGA CTCCTTCCTC AGGAGACTGG GGCTTACCAA ACTCAAAGGC CGGCAGAATG GAACCTATGA ATTCAAACTC CATGGGAAGA CCAGGAGGAG ATTATAATAC TTCTTTACCC AGACCTGCAC TGGGTGGCTC TATTCCCACA TTGCCTCTTC GGTCTAATAG CATACCAGGT GCGAGACCAG TATTGCAACA GCAGCAGCAG ATGCTTCAAA TGAGGCCTGG TGAAATCCCC ATGGGAATGG GGGCTAATCC CTATGGCCAA GCAGCAGCAT CTAACCAACT GGGTTCCTGG CCCGATGGCA TGTTGTCCAT GGAACAAGTT TCTCATGGCA CTCAAAATAG GCCTCTTCTT AGGAATTCCC TGGATGATCT TGTTGGGCCA CCTTCCAACC TGGAAGGCCA GAGTGACGAA AGAGCATTAT TGGACCAGCT GCACACTCTT CTCAGCAACA CAGATGCCAC AGGCCTGGAA GAAATTGACA GAGCTTTGGG CATTCCTGAA CTTGTCAATC AGGGACAGGC ATTAGAGCCC AAACAGGATG CTTTCCAAGG CCAAGAAGCA GCAGTAATGA TGGATCAGAA GGCAGGATTA TATGGACAGA CATACCCAGC ACAGGGGCCT CCAATGCAAG GAGGCTTTCA TCTTCAGGGA CAATCACCAT CTTTTAACTC TATGATGAAT CAGATGAACC AGCAAGGCAA TTTTCCTCTC CAAGGAATGC ACCCACGAGC CAACATCATG AGACCCCGGA CAAACACCCC CAAGCAACTT AGAATGCAGC TTCAGCAGAG GCTGCAGGGC CAGCAGTTTT TGAATCAGAG CCGACAGGCA CTTGAATTGA AAATGGAAAA CCCTACTGCT GGTGGTGCTG CGGTGATGAG GCCTATGATG CAGCCCCAGC AGGGTTTTCT TAATGCTCAA ATGGTCGCCC AACGCAGCAG AGAGCTGCTA AGTCATCACT TCCGACAACA GAGGGTGGCT ATGATGATGC AGCAGCAGCA GCAGCAGCAA CAGCAGCAGC AGCAGCAGCA GCAGCAGCAA CAGCAACAGC AACAGCAACA GCAGCAACAG CAGCAAACCC AGGCCTTCAG CCCACCTCCT AATGTGACTG CTTCCCCCAG CATGGATGGG CTTTTGGCAG GACCCACAAT GCCACAAGCT CCTCCGCAAC AGTTTCCATA TCAACCAAAT TATGGAATGG GACAACAACC AGATCCAGCC TTTGGTCGAG TGTCTAGTCC TCCCAATGCA ATGATGTCGT CAAGAATGGG TCCCTCCCAG AATCCCATGA TGCAACACCC GCAGGCTGCA TCCATCTATC AGTCCTCAGA AATGAAGGGC TGGCCATCAG GAAATTTGGC CAGGAACAGC TCCTTTTCCC AGCAGCAGTT TGCCCACCAG GGGAATCCTG CAGTGTATAG TATGGTGCAC ATGAATGGCA GCAGTGGTCA CATGGGACAG ATGAACATGA ACCCCATGCC CATGTCTGGC ATGCCTATGG GTCCTGATCA GAAATACTGC TGA. It is sometimes possible for the material contained within the vial of "NCOA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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