NANOS2 cdna clone
NANOS2 cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
NANOS2: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. Belongs to the nanos family.
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: protein binding
Biological Process: germ-line stem cell maintenance; mRNA catabolic process; negative regulation of meiosis; negative regulation of translation; spermatogenesis
Research Articles on NANOS2
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Product Notes
The NANOS2 nanos2 (Catalog #AAA1277476) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgcagctgc cacccttcga catgtggaag gactacttca acctgagcca ggtggtgtgg gcgctgatcg caagtcgggg tcaaaggctg gagacccaag agattgagga gccaagtccc gggcctccgc tggggcagga tcaggggctg ggggcgccag gggccaacgg gggcctgggg accctgtgca acttctgcaa gcacaacggg gagtcccgcc acgtctactc ctcacaccag ctgaagacac cggatggcgt ggtggtgtgt cccatcctga ggcactacgt gtgtcccgtg tgcggggcca ccggtgacca ggcccatacg ctcaagtact gcccgcttaa cggtggccag cagtccctct accgccgcag cgggcgcaac tcggccggac gcagggtcaa gcgctga. It is sometimes possible for the material contained within the vial of "NANOS2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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