MYH7 cdna clone
MYH7 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]
Uniprot Description
MYH7: Muscle contraction. Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: muscle myosin complex; myosin complex; sarcomere
Molecular Function: actin-dependent ATPase activity; ATPase activity; microfilament motor activity; protein binding
Biological Process: adult heart development; ATP metabolic process; cardiac muscle contraction; muscle contraction; muscle filament sliding; regulation of heart rate; regulation of slow-twitch skeletal muscle contraction; regulation of the force of heart contraction; regulation of the force of skeletal muscle contraction; skeletal muscle contraction; striated muscle contraction; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Dilated, 1s; Cardiomyopathy, Familial Hypertrophic, 1; Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Distal, 1; Myopathy, Myosin Storage; Myopathy, Myosin Storage, Autosomal Recessive; Scapuloperoneal Myopathy, Myh7-related
Research Articles on MYH7
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Product Notes
The MYH7 myh7 (Catalog #AAA1273006) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggagatt cggagatggc agtctttggg gctgccgccc cctacctgcg caagtcagag aaggagcggc tagaagcgca gaccaggcct tttgacctca agaaggatgt cttcgtgcct gatgacaaac aggagtttgt caaggccaag atcgtgtctc gagagggtgg caaagtcact gccgagactg agtatggcaa gacagtgacc gtgaaggagg accaggtgat gcagcagaac ccacccaagt tcgacaaaat cgaggacatg gccatgctga ccttcctgca tgagcccgcg gtgctctaca acctcaagga tcgctacggc tcctggatga tctacaccta ctcgggcctc ttctgtgtca ccgtcaaccc ttacaagtgg ctgccggtgt acactcctga ggtggtggct gcctaccggg gcaagaagag gagcgaggcc ccgccccaca tcttctccat ctccgacaac gcctatcagt acatgctgac agacagagaa aaccagtcca tcctgatcac cggagaatcc ggagcaggga agacagtcaa caccaagagg gtcatccagt actttgctgt tattgcagcc attggggacc gcagcaagaa ggaccagagc ccgggcaagg gcaccctgga ggaccagatc atccaggcca accctgctct ggaggccttt ggcaatgcca agaccgtccg gaacgacaac tcctcccgct ttgggaaatt cattcgaatt cattttgggg caacaggaaa gttggcatct gcagacatag agacctatct tctggaaaaa tccagagtta ttttccagct gaaagcagag agagattatc acattttcta ccaaatcctg tctaacaaaa agcctgagct gctggacatg ctgctgatca ccaacaaccc ctacgattat gcattcatct cccaaggaga gaccaccgtg gcctccattg atgacgctga ggagctcatg gccactgata acgcttttga tgtgctgggc ttcacttcag aggagaaaaa ctccatgtat aagctgacag gtgccatcat gcactttgga aacatgaagt tcaagctgaa gcagcgggag gagcaggcgg agccagacgg cactgaagag gctgacaagt ctgcctacct catggggctg aactcagccg acctgctcaa ggggctgtgc caccctcggg tgaaagtggg caatgagtac gtcaccaagg ggcagaatgt ccagcaggtg atatatgcca ctggggcact ggccaaggca gtgtatgaga ggatgttcaa ctggatggtg acgcgcatca atgccaccct ggagaccaag cagccacgcc agtacttcat aggagtcctg gacatcgctg gcttcgagat cttcgatttc aacagctttg agcagctctg catcaacttc accaacgaga agctgcagca gttcttcaac caccacatgt ttgtgctgga gcaggaggag tacaagaagg agggcatcga gtggacattc attgactttg gcatggacct gcaggcctgc attgacctca tcgagaagcc catgggcatc atgtccatcc tggaagagga gtgcatgttc cccaaggcca ccgacatgac cttcaaggcc aagctgtttg acaaccacct gggcaaatcc gccaacttcc agaagccacg caatatcaag gggaagcctg aagcccactt ctccctgatc cactatgccg gcatcgtgga ctacaacatc attggctggc tgcagaagaa caaggatcct ctcaatgaga ctgtcgtggg cttgtatcag aagtcttccc tcaagctgct cagcaccctg tttgccaact atgctggggc tgatgcgcct attgagaagg gcaaaggcaa ggccaagaaa ggctcgtcct ttcagactgt gtcagctctg cacagggaaa atctgaacaa gctgatgacc aacttgcgct ccacccatcc ccactttgta cgttgtatca tccctaatga gacaaagtct ccaggggtga tggacaaccc cctggtcatg caccagctgc gctgcaatgg tgtgctggag ggcatccgca tctgcaggaa aggcttcccc aaccgcatcc tctacgggga cttccggcag aggtatcgca tcctgaaccc agcggccatc cctgagggac agttcattga tagcaggaag ggggcagaga agctgctcag ctccctggac attgatcaca accagtacaa gtttggccac accaaggtgt tcttcaaggc cgggctgctg gggctgctgg aggaaatgag ggacgagagg ctgagccgca tcatcacgcg tatccaggcc cagtcccgag gtgtgctcgc cagaatggag tacaaaaagc tgctggaacg tagagactcc ctgctggtaa tccagtggaa cattcgggcc ttcatggggg tcaagaattg gccctggatg aagctctact tcaagatcaa gccgctgctg aagagtgcag aaagagagaa ggagatggcc tccatgaagg aggagttcac acgcctcaaa gaggcgctag agaagtccga ggctcgccgc aaggagctgg aggagaagat ggtgtccctg ctgcaggaga agaatgacct gcagctccaa gtgcaggcgg aacaagacaa cctggcagat gctgaggagc gctgtgatca gctgatcaaa aacaagattc agctggaggc caaggtgaag gagatgaacg agaggctgga ggatgaggag gagatgaatg ctgagctcac tgccaagaag cgcaagctgg aagatgagtg ctcagagctc aaaagggaca tcgatgatct ggagctgaca ctggccaaag tggagaagga gaaacacgca acagagaaca aggtgaaaaa cctgacagag gagatggctg ggctggatga gatcatcgcc aagctgacca aggagaagaa agctctgcaa gaggcccacc aacaggctct ggatgacctt caggccgagg aggacaaggt caacaccctg actaaggcca aagtcaagct ggagcagcaa gtggatgatc tggaaggatc cctggagcaa gagaagaagg tgcgcatgga cctggagcga gcgaagcgga agctggaggg cgacctgaag ctgacccagg agagcatcat ggacctggag aatgacaagc agcagctgga tgagcggctg aaaaaaaaag actttgagct gaatgctctc aacgcaagga ttgaggatga acaggccctc ggcagccagc tgcagaagaa gctcaaggag cttcaggcac gcatcgagga gctggaggag gagctggagg ccgagcgcac cgccagggct aaggtggaga agctgcgctc agacctgtct cgggagctgg aggagatcag cgagcggctg gaagaggccg gcggggccac gtccgtgcag atcgagatga acaagaagcg cgaggccgag ttccagaaga tgcggcggga cctggaggag gccacgctgc agcacgaggc cactgccgcg gccctgcgca agaagcacgc cgacagcgtg gccgagctgg gcgagcagat cgacaacctg cagcgggtga agcagaagct ggagaaggag aagagcgagt tcaagctgga gctggatgac gtcacctcca acatggagca gatcatcaag gccaaggcta acctggagaa gatgtgccgg accttggaag accagatgaa tgagcaccgg agcaaggcgg aggagaccca gcgttctgtc aacgacctca ccagccagcg ggccaagttg caaaccgaga atggtgagct gtcccggcag ctggatgaga aggaggcact gatctcccag ctgacccgag gcaagctcac ctacacccag cagctggagg acctcaagag gcagctggag gaggaggtta aggcgaagaa cgccctggcc cacgcactgc agtcggcccg gcatgactgc gacctgctgc gggagcagta cgaggaggag acggaggcca aggccgagct gcagcgcgtc ctttccaagg ccaactcgga ggtggcccag tggaggacca agtatgagac ggacgccatt cagcggactg aggagctcga ggaggccaag aagaagctgg cccagcggct gcaggaagct gaggaggccg tggaggctgt taatgccaag tgctcctcgc tggagaagac caagcaccgg ctacagaatg agatcgagga cttgatggtg gacgtagagc gctccaatgc tgctgctgca gccctggaca agaagcagag gaacttcgac aagatcctgg ccgagtggaa gcagaagtat gaggagtcgc agtcggagct ggagtcctcg cagaaggagg ctcgctccct cagcacagag ctcttcaaac tcaagaacgc ctatgaggag tccctggaac atctggagac cttcaagcgg gagaacaaaa acctgcagga ggagatctcc gacttgactg agcagttggg ttccagcgga aagactatcc atgagctgga gaaggtccga aagcagctgg aggccgagaa gatggagctg cagtcagccc tggaggaggc cgaggcctcc ctggagcacg aggagggcaa gatcctccgg gcccagctgg agttcaacca gatcaaggca gagatcgagc ggaagctggc agagaaggac gaggagatgg aacaggccaa gcgcaaccac ctgcgggtgg tggactcgct gcagacctcc ctggacgcag agacacgcag ccgcaacgag gccctgaggg tgaagaagaa gatggaagga gacctcaatg agatggagat ccagctcagc cacgccaacc gcatggccgc cgaggcccag aagcaagtca agagcctcca gagcttgttg aaggacaccc agattcagct ggacgatgca gtccgtgcca acgacgacct gaaggagaac atcgccatcg tggagcggcg caacaacctg ctgcaggctg agctggagga gttgcgtgcc gtggtggagc agacagagcg gtcccggaag ctggcggagc aggagctgat tgagactagt gagcgggtgc agctgctgca ttcccagaac accagcctca tcaaccagaa gaagaagatg gatgctgacc tgtcccagct ccagactgaa gtggaggagg cagtgcagga gtgcaggaat gctgaggaga aggccaagaa ggccatcacg gatgccgcca tgatggcaga ggagctgaag aaggagcagg acaccagcgc ccacctggag cgcatgaaga agaacatgga acagaccatt aaggacctgc agcaccggct ggacgaagcc gagcagatcg ccctcaaggg cggcaagaag cagctgcaga agctggaagc gcgggtgcgg gagctggaga atgagctgga ggccgagcag aagcgcaacg cagagtcggt gaagggcatg aggaagagcg agcggcgcat caaggagctc acctaccaga cggaggagga caggaaaaac ctgctgcggc tgcaggacct ggtagacaag ctgcagctaa aggtcaaggc ctacaagcgc caggccgagg aggcggagga gcaagccaac accaacctgt ccaagttccg caaggtgcag cacgagctgg atgaggcaga ggagcgggcg gacatcgccg agtcccaggt caacaagctg cgggccaaga gccgtgacat tggcacgaag ggcttgaatg aggagtag. It is sometimes possible for the material contained within the vial of "MYH7, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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