MUTYH cdna clone
MUTYH cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Hydrolase; DNA repair, damage; Tumor suppressor; EC 3.2.2.-
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding
Biological Process: depurination; DNA repair; mismatch repair
Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma
Research Articles on MUTYH
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Product Notes
The MUTYH mutyh (Catalog #AAA1268739) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgacaccgc tcgtctcccg cctgagtcgt ctgtgggcca tcatgaggaa gccacgagca gccgtgggaa gtggtcacag gaagcaggca gccagccagg aagggaggca gaagcatgct aagaacaaca gtcaggccaa gccttctgcc tgtgatggcc tggccaggca gccggaagag gtggtattgc aggcctctgt ctcctcatac catctattca gagacgtagc tgaagtcaca gccttccgag ggagcctgct aagctggtac gaccaagaga aacgggacct accatggaga agacgggcag aagatgagat ggacctggac aggcgggcat atgctgtgtg ggtctcagag gtcatgctgc agcagaccca ggttgccact gtgatcaact actataccgg atggatgcag aagtggccta cactgcagga cctggccagt gcttccctgg aggaggtgaa tcaactctgg gctggcctgg gctactattc tcgtggccgg cggctgcagg agggagctcg gaaggtggta gaggagctag ggggccacat gccacgtaca gcagagaccc tgcagcagct cctgcctggc gtggggcgct acacagctgg ggccattgcc tctatcgcct ttggccaggc aaccggtgtg gtggatggca acgtagcacg ggtgctgtgc cgtgtccgag ccattggtgc tgatcccagc agcacccttg tttcccagca gctctggggt ctagcccagc agctggtgga cccagcccgg ccaggagatt tcaaccaagc agccatggag ctaggggcca cagtgtgtac cccacagcgc ccactgtgca gccagtgccc tgtggagagc ctgtgccggg cacgccagag agtggagcag gaacagctct tagcctcagg gagcctgtcg ggcagtcctg acgtggagga gtgtgctccc aacactggac agtgccacct gtgcctgcct ccctcggagc cctgggacca gaccctggga gtggtcaact tccccagaaa ggccagccgc aagcccccca gggaggagag ctctgccacc tgtgttctgg aacagcctgg ggcccttggg gcccaaattc tgctggtgca gaggcccaac tcaggtctgc tggcaggact gtgggagttc ccgtccgtga cctgggagcc ctcagagcag cttcagcgca aggccctgct gcaggaacta cagcgttggg ctgggcccct cccagccacg cacctccggc accttgggga ggttgtccac accttctctc acatcaagct gacatatcaa gtatatgggc tggccttgga agggcagacc ccagtgacca ccgtaccacc aggtgctcgc tggctgacgc aggaggaatt tcacaccgca gctgtttcca ccgccatgaa aaaggttttc cgtgtgtatc agggccaaca gccagggacc tgtatgggtt ccaaaaggtc ccaggtgtcc tctccgtgca gtcggaaaaa gccccgcatg ggccagcaag tcctggataa tttctttcgg tctcacatct ccactgatgc acacagcctc aacagtgcag cccagtga. It is sometimes possible for the material contained within the vial of "MUTYH, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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