MCEE cdna clone
MCEE cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Uniprot Description
MCEE: Defects in MCEE are a cause of methylmalonyl-CoA epimerase deficiency (MCEED); also known as methylmalonyl-CoA racemase deficiency or methylmalonic aciduria type 3. MCEE deficiency is an autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Belongs to the glyoxalase I family.
Protein type: EC 5.1.99.1; Mitochondrial; Isomerase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: mitochondrial matrix
Molecular Function: methylmalonyl-CoA epimerase activity; protein binding
Biological Process: L-methylmalonyl-CoA metabolic process; short-chain fatty acid catabolic process
Disease: Methylmalonyl-coa Epimerase Deficiency
Research Articles on MCEE
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Product Notes
The MCEE mcee (Catalog #AAA1270556) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcgcggg tgctgaaggc tgcagccgcg aatgccgtag ggcttttttc cagacttcaa gctcccattc caacagtaag agcttcttcc acatcacagc ccttggatca agtgacaggt tctgtgtgga acctgggtcg actcaaccat gtagccatag cagtgccaga tttggaaaag gctgcagcat tttataagaa tattctgggg gcccaggtaa gtgaagcggt ccctcttcct gaacatggag tatctgttgt ttttgtcaac ctgggaaata ccaagatgga actgcttcat ccattgggac ttgacagtcc aattgcaggt tttctgcaga aaaacaaggc tggaggaatg catcacatct gcatcgaggt ggataatatt aatgcagctg tgatggattt gaaaaaaaag aagatccgca gtctaagtga agaggtcaaa ataggagcac atggaaaacc agtgattttt ctccatccta aagactgtgg tggagtcctt gtggaactgg agcaagcttg a. It is sometimes possible for the material contained within the vial of "MCEE, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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