MBL2 cdna clone
MBL2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]
Uniprot Description
MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cell surface; extracellular region; extracellular space
Molecular Function: calcium ion binding; calcium-dependent protein binding; mannose binding; protein binding; receptor binding; serine-type endopeptidase activity
Biological Process: acute-phase response; complement activation; complement activation, lectin pathway; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response; negative regulation of viral reproduction; opsonization
Disease: Mannose-binding Protein Deficiency
Research Articles on MBL2
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Product Notes
The MBL2 mbl2 (Catalog #AAA1268696) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTCCCTGT TTCCATCACT CCCTCTCCTT CTCCTGAGTA TGGTGGCAGC GTCTTACTCA GAAACTGTGA CCTGTGAGGA TGCCCAAAAG ACCTGCCCTG CAGTGATTGC CTGTAGCTCT CCAGGCATCA ACGGCTTCCC AGGCAAAGAT GGGCGTGATG GCACCAAGGG AGAAAAGGGG GAACCAGGCC AAGGGCTCAG AGGCTTACAG GGCCCCCCTG GAAAGTTGGG GCCTCCAGGA AATCCAGGGC CTTCTGGGTC ACCAGGACCA AAGGGCCAAA AAGGAGACCC TGGAAAAAGT CCGGATGGTG ATAGTAGCCT GGCTGCCTCA GAAAGAAAAG CTCTGCAAAC AGAAATGGCA CGTATCAAAA AGTGGCTCAC CTTCTCTCTG GGCAAACAAG TTGGGAACAA GTTCTTCCTG ACCAATGGTG AAATAATGAC CTTTGAAAAA GTGAAGGCCT TGTGTGTCAA GTTCCAGGCC TCTGTGGCCA CCCCCAGGAA TGCTGCAGAG AATGGAGCCA TTCAGAATCT CATCAAGGAG GAAGCCTTCC TGGGCATCAC TGATGAGAAG ACAGAAGGGC AGTTTGTGGA TCTGACAGGA AATAGACTGA CCTACACAAA CTGGAACGAG GGTGAACCCA ACAATGCTGG TTCTGATGAA GATTGTGTAT TGCTACTGAA AAATGGCCAG TGGAATGACG TCCCCTGCTC CACCTCCCAT CTGGCCGTCT GTGAGTTCCC TATCTGA. It is sometimes possible for the material contained within the vial of "MBL2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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