MASP1 cdna clone
MASP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Description
MASP1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1). 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 3q27-q28
Cellular Component: extracellular region; extracellular space
Molecular Function: calcium ion binding; calcium-dependent protein binding; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, lectin pathway; receptor-mediated endocytosis
Disease: 3mc Syndrome 1
Research Articles on MASP1
Similar Products
Product Notes
The MASP1 masp1 (Catalog #AAA1266846) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGGTGGC TGCTTCTCTA TTATGCTCTG TGCTTCTCCC TGTCAAAGGC TTCAGCCCAC ACCGTGGAGC TAAACAATAT GTTTGGCCAG ATCCAGTCGC CTGGTTATCC AGACTCCTAT CCCAGTGATT CAGAGGTGAC TTGGAATATC ACTGTCCCAG ATGGGTTTCG GATCAAGCTT TACTTCATGC ACTTCAACTT GGAATCCTCC TACCTTTGTG AATATGACTA TGTGAAGGTA GAAACTGAGG ACCAGGTGCT GGCAACCTTC TGTGGCAGGG AGACCACAGA CACAGAGCAG ACTCCCGGCC AGGAGGTGGT CCTCTCCCCT GGCTCCTTCA TGTCCATCAC TTTCCGGTCA GATTTCTCCA ATGAGGAGCG TTTCACAGGC TTTGATGCCC ACTACATGGC TGTGGATGTG GACGAGTGCA AGGAGAGGGA GGACGAGGAG CTGTCCTGTG ACCACTACTG CCACAACTAC ATTGGCGGCT ACTACTGCTC CTGCCGCTTC GGCTACATCC TCCACACAGA CAACAGGACC TGCCGAGTGG AGTGCAGTGA CAACCTCTTC ACTCAAAGGA CTGGGGTGAT CACCAGCCCT GACTTCCCAA ACCCTTACCC CAAGAGCTCT GAATGCCTGT ATACCATCGA GCTGGAGGAG GGTTTCATGG TCAACCTGCA GTTTGAGGAC ATATTTGACA TTGAGGACCA TCCTGAGGTG CCCTGCCCCT ATGACTACAT CAAGATCAAA GTTGGTCCAA AAGTTTTGGG GCCTTTCTGT GGAGAGAAAG CCCCAGAACC CATCAGCACC CAGAGCCACA GTGTCCTGAT CCTGTTCCAT AGTGACAACT CGGGAGAGAA CCGGGGCTGG AGGCTCTCAT ACAGGGCTGC AGGAAATGAG TGCCCAGAGC TACAGCCTCC TGTCCATGGG AAAATCGAGC CCTCCCAAGC CAAGTATTTC TTCAAAGACC AAGTGCTCGT CAGCTGTGAC ACAGGCTACA AAGTGCTGAA GGATAATGTG GAGATGGACA CATTCCAGAT TGAGTGTCTG AAGGATGGGA CGTGGAGTAA CAAGATTCCC ACCTGTAAAA TTGTAGACTG TAGAGCCCCA GGAGAGCTGG AACACGGGCT GATCACCTTC TCTACAAGGA ACAACCTCAC CACATACAAG TCTGAGATCA AATACTCCTG TCAGGAGCCC TATTACAAGA TGCTCAACAA TAACACAGGT ATATATACCT GTTCTGCCCA AGGAGTCTGG ATGAATAAAG TATTGGGGAG AAGCCTACCC ACCTGCCTTC CAGAGTGTGG TCAGCCCTCC CGCTCCCTGC CAAGCCTGGT CAAGAGGATC ATTGGGGGCC GAAATGCTGA GCCCGGCCTC TTCCCGTGGC AGGCCCTGAT AGTGGTGGAG GACACTTCGA GAGTGCCAAA TGACAAGTGG TTTGGGAGTG GGGCCCTGCT CTCTGCGTCC TGGATCCTCA CAGCAGCTCA TGTGCTGCGC TCCCAGCGTA GAGACACCAC GGTGATACCA GTCTCCAAGG AGCATGTCAC CGTCTACCTG GGCTTGCATG ATGTGCGAGA CAAATCGGGG GCAGTCAACA GCTCAGCTGC CCGAGTGGTG CTCCACCCAG ACTTCAACAT CCAAAACTAC AACCACGATA TAGCTCTGGT GCAGCTGCAG GAGCCTGTGC CCCTGGGACC CCACGTTATG CCTGTCTGCC TGCCAAGGCT TGAGCCTGAA GGCCCGGCCC CCCACATGCT GGGCCTGGTG GCCGGCTGGG GCATCTCCAA TCCCAATGTG ACAGTGGATG AGATCATCAG CAGTGGCACA CGGACCTTGT CAGATGTCCT ACAGTATGTC AAGTTACCCG TGGTGCCTCA CGCTGAGTGC AAAACTAGCT ATGAGTCCCG CTCGGGCAAT TACAGCGTCA CGGAGAACAT GTTCTGTGCT GGCTACTACG AGGGCGGCAA AGACACGTGC CTTGGAGATA GCGGTGGGGC CTTTGTCATC TTTGATGACT TGAGCCAGCG CTGGGTGGTG CAAGGCCTGG TGTCCTGGGG GGGACCTGAA GAATGCGGCA GCAAGCAGGT CTATGGAGTC TACACAAAGG TCTCCAATTA CGTGGACTGG GTGTGGGAGC AGATGGGCTT ACCACAAAGT GTTGTGGAGC CCCAGGTGGA ACGGTGA. It is sometimes possible for the material contained within the vial of "MASP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
