MAPKAP1 cdna clone
MAPKAP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Sin1: a member of a conserved family of proteins that have an essential roles in signal transduction from yeast to mammals. An essential component of the mTORC2 complex, which consists of mTOR, LST8, Sin1, Protor (PRR5), and RICTOR, the Rapamycin Insensitive Companion of mTOR. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 regulates the phosphorylation of SGK1 S422 and PKCA S657. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Contains a Ras-binding (RBD) and a pleckstrin homology (PH) domains. Plays an important role in the SAPK signaling pathway by binding directly to both ATF-2 and p38. A genetic knockout of Sin1 abolished Akt-S473 phosphorylation and disrupts the RICTOR-mTOR interaction, but Akt-Thr308 phosphorylation is maintained. Six alternatively-spliced isoforms of the human protein have been reported. All isoforms except 4 can be incorporated into the the mTORC2 complex.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane
Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein kinase binding; Ras GTPase binding
Biological Process: negative regulation of Ras protein signal transduction; phosphoinositide-mediated signaling; substantia nigra development; T cell costimulation
Research Articles on MAPKAP1
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Product Notes
The MAPKAP1 mapkap1 (Catalog #AAA1269221) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccttct tggacaatcc aactatcatt ctagctcata ttcgacagtc acatgtgacc agtgatgaca cgggaatgtg tgagatggtt ctcattgatc atgatgttga cctagagaag attcatcctc cttcaatgcc tggagacagt gggtcagaaa ttcagggaag caatggtgag actcagggct atgtatatgc ccagtcagtc gatattacct caagttggga ctttggtatt agaagacgct caaacacagc tcaaagatta gaacgactcc gaaaagagag acaaaaccag atcaaatgca aaaatattca gtggaaagaa agaaattcta agcaatcagc ccaggagtta aagtcactgt ttgaaaaaaa atctctcaaa gagaagcctc caatttctgg gaagcagtcg atattatctg tacgcctaga acagtgccct ctgcagctga ataacccttt taacgagtat tccaaatttg atggcaaggg tcatgtaggt acaacagcaa ccaagaagat cgatgtctac ctccctctgc actcgagcca ggacagactg ctgccaatga ccgtggtgac aatggccagc gccagggtgc aggacctgat cgggctcatc tgctggcagt atacaagcga aggacgggag ccgaagctca atgacaatgt cagtgcctac tgcctgcata ttgctgagga tgatggggag gtggacaccg atttcccccc gctggattcc aatgagccca ttcataagtt tggcttcagt actttggccc tggttgaaaa gtactcatct cctggtctga catccaaaga gtcactcttt gttcgaataa atgctgctca tggattctcc cttattcagg tggacaacac aaaggttacc atgaaggaaa tcttactgaa ggcagtgaag cgaagaaaag gatcccagaa agtttcaggt tcaagggcag acggggtttt tgaggaggat tcgcaaattg acatagccac agtacaggat atgcttagca gccaccatta caagtcattc aaagtcagca tgatccacag actgcgattc acaaccgacg tacagctagg tatctctgga gacaaagtag agatagaccc tgttacgaat cagaaagcca gcactaagtt ttggattaag cagaaaccca tctcaatcga ttccgacctg ctctgtgcct gtgaccttgc tgaagagaaa agccccagtc acgcaatatt taaactcacg tatctaagca atcacgacta taaacacctc tactttgaat cggacgctgc taccgtcaat gaaattgtgc tcaaggttaa ctacatcctg gaatcgcgag ctagcactgc ccgggctgac tactttgctc aaaaacaaag aaaactgaac agacgtacga gcttcagctt ccagaaggag aagaaatccg ggcagcagtg a. It is sometimes possible for the material contained within the vial of "MAPKAP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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