LYN cdna clone
LYN cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Description
LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling.
Protein type: EC 2.7.10.2; Oncoprotein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; Src family
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; Golgi apparatus; lipid raft; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; receptor signaling protein tyrosine kinase activity
Biological Process: B cell homeostasis; blood coagulation; central nervous system development; ephrin receptor signaling pathway; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; immune response-regulating cell surface receptor signaling pathway; inflammatory response; innate immune response; leukocyte migration; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of immune response; negative regulation of MAP kinase activity; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; peptidyl-tyrosine phosphorylation; platelet activation; platelet degranulation; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of erythrocyte differentiation; regulation of mast cell activation; regulation of mast cell degranulation; regulation of protein amino acid phosphorylation; response to DNA damage stimulus; response to hormone stimulus; signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on LYN
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Product Notes
The LYN lyn (Catalog #AAA1275944) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggatgta taaaatcaaa agggaaagac agcttgagtg acgatggagt agatttgaag actcaaccag tacgtaatac tgaaagaact atttatgtga gagatccaac gtccaataaa cagcaaaggc cagttccaga atctcagctt ttacctggac agaggtttca aactaaagat ccagaggaac aaggagacat tgtggtagcc ttgtacccct atgatggcat ccacccggac gacttgtctt tcaagaaagg agagaagatg aaagtcctgg aggagcatgg agaatggtgg aaagcaaagt cccttttaac aaaaaaagaa ggcttcatcc ccagcaacta tgtggccaaa ctcaacacct tagaaacaga agagtggttt ttcaaggata taaccaggaa ggacgcagaa aggcagcttt tggcaccagg aaatagcgct ggagctttcc ttattagaga aagtgaaaca ttaaaaggaa gcttctctct gtctgtcaga gactttgacc ctgtgcatgg tgatgttatt aagcactaca aaattagaag tctggataat gggggctatt acatctctcc acgaatcact tttccctgta tcagcgacat gattaaacat taccaaaagc aggcagatgg cttgtgcaga agattggaga aggcttgtat tagtcccaag ccacagaagc catgggataa agatgcctgg gagatccccc gggagtccat caagttggtg aaaaggcttg gcgctgggca gtttggggaa gtctggatgg gttactataa caacagtacc aaggtggctg tgaaaaccct gaagccagga actatgtctg tgcaagcctt cctggaagaa gccaacctca tgaagaccct gcagcatgac aagctcgtga ggctctacgc tgtggtcacc agggaggagc ccatttacat catcaccgag tacatggcca agggcagttt gctggatttc ctgaagagcg atgaaggtgg caaagtgctg cttccaaagc tcattgactt ttctgctcag attgcagagg gaatggcata catcgagcgg aagaactaca ttcaccggga cctgcgagca gctaatgttc tggtctccga gtcactcatg tgcaaaattg cagattttgg ccttgctaga gtaattgaag ataatgagta cacagcaagg gaaggtgcta agttccctat taagtggacg gctccagaag caatcaactt tggatgtttc actattaagt ctgatgtgtg gtcctttgga atcctcctat acgaaattgt cacctatggg aaaattccct acccagggag aactaatgcc gacgtgatga ccgccctgtc ccagggctac aggatgcccc gtgtggagaa ctgcccagat gagctctatg acattatgaa aatgtgctgg aaagaaaagg cagaagagag accaacgttt gactacttac agagcgtcct ggatgatttc tacacagcca cggaagggca ataccagcag cagccttag. It is sometimes possible for the material contained within the vial of "LYN, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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