LGALS9 cdna clone
LGALS9 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
galectin-9: Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytoplasm; extracellular space; intracellular; nucleus
Molecular Function: carbohydrate binding; disaccharide binding; enzyme binding; galactose binding; signal transducer activity
Biological Process: activation of NF-kappaB transcription factor; female pregnancy; inflammatory response; maternal process involved in pregnancy; natural killer cell tolerance induction; negative regulation of activated T cell proliferation; negative regulation of chemokine production; negative regulation of interferon-gamma production; negative regulation of mast cell degranulation; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-4 production; positive regulation of NF-kappaB import into nucleus; positive regulation of virion penetration into host cell; regulation of interleukin-4 production; regulation of interleukin-5 production; response to lipopolysaccharide; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway
Research Articles on LGALS9
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Product Notes
The LGALS9 lgals9 (Catalog #AAA7046744) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCTTCA GCGGTTCCCA GGCTCCCTAC CTGAGTCCAG CTGTCCCCTT TTCTGGGACT ATTCAAGGAG GTCTCCAGGA CGGACTTCAG ATCACTGTCA ATGGGACCGT TCTCAGCTCC AGTGGAACCA GGTTTGCTGT GAACTTTCAG ACTGGCTTCA GTGGAAATGA CATTGCCTTC CACTTCAACC CTCGGTTTGA AGATGGAGGG TACGTGGTGT GCAACACGAG GCAGAACGGA AGCTGGGGGC CCGAGGAGAG GAAGACACAC ATGCCTTTCC AGAAGGGGAT GCCCTTTGAC CTCTGCTTCC TGGTGCAGAG CTCAGATTTC AAGGTGATGG TGAACGGGAT CCTCTTCGTG CAGTACTTCC ACCGCGTGCC CTTCCACCGT GTGGACACCA TCTCCGTCAA TGGCTCTGTG CAGCTGTCCT ACATCAGCTT CCAGCCTCCC GGCGTGTGGC CTGCCAACCC GGCTCCCATT ACCCAGACAG TCATCCACAC AGTGCAGAGC GCCCCTGGAC AGATGTTCTC TACTCCCGCC ATCCCACCTA TGATGTACCC CCACCCCGCC TATCCGATGC CTTTCATCAC CACCATTCTG GGAGGGCTGT ACCCATCCAA GTCCATCCTC CTGTCAGGCA CTGTCCTGCC CAGTGCTCAG AGGTTCCACA TCAACCTGTG CTCTGGGAAC CACATCGCCT TCCACCTGAA CCCCCGTTTT GATGAGAATG CTGTGGTCCG CAACACCCAG ATCGACAACT CCTGGGGGTC TGAGGAGCGA AGTCTGCCCC GAAAAATGCC CTTCGTCCGT GGCCAGAGCT TCTCAGTGTG GATCTTGTGT GAAGCTCACT GCCTCAAGGT GGCCGTGGAT GGTCAGCACC TGTTTGAATA CTACCATCGC CTGAGGAACC TGCCCACCAT CAACAGACTG GAAGTGGGGG GCGACATCCA GCTGACCCAT GTGCAGACAT AG. It is sometimes possible for the material contained within the vial of "LGALS9, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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