KLK6 cdna clone
KLK6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Uniprot Description
KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; Nucleolus; EC 3.4.21.-; Secreted
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: cytoplasm; extracellular region; extracellular space; intercellular bridge; microtubule cytoskeleton; nuclear membrane; nucleoplasm
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: positive regulation of G-protein coupled receptor protein signaling pathway; protein processing
Research Articles on KLK6
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Product Notes
The KLK6 klk6 (Catalog #AAA1266805) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagaagc tgatggtggt gctgagtctg attgctgcag cctgggcaga ggagcagaat aagttggtgc atggcggacc ctgcgacaag acatctcacc cctaccaagc tgccctctac acctcgggcc acttgctctg tggtggggtc cttatccatc cactgtgggt cctcacagct gcccactgca aaaaaccgaa tcttcaggtc ttcctgggga agcataacct tcggcaaagg gagagttccc aggagcagag ttctgttgtc cgggctgtga tccaccctga ctatgatgcc gccagccatg accaggacat catgctgttg cgcctggcac gcccagccaa actctctgaa ctcatccagc cccttcccct ggagagggac tgctcagcca acaccaccag ctgccacatc ctgggctggg gcaagacagc agatggtgat ttccctgaca ccatccagtg tgcatacatc cacctggtgt cccgtgagga gtgtgagcat gcctaccctg gccagatcac ccagaacatg ttgtgtgctg gggatgagaa gtacgggaag gattcctgcc agggtgattc tgggggtccg ctggtatgtg gagaccacct ccgaggcctt gtgtcatggg gtaacatccc ctgtggatca aaggagaagc caggagtcta caccaacgtc tgcagataca cgaactggat ccaaaaaacc attcaggcca agtga. It is sometimes possible for the material contained within the vial of "KLK6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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