KIR2DL1 cdna clone
KIR2DL1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Uniprot Description
KIR2DL1: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Belongs to the immunoglobulin superfamily.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; receptor activity
Biological Process: immune response; natural killer cell inhibitory signaling pathway; regulation of immune response
Research Articles on KIR2DL1
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Product Notes
The KIR2DL1 kir2dl1 (Catalog #AAA1278230) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcgctct tggtcgtcag catggcgtgt gttgggttct tcttgctgca gggggcctgg ccacatgagg gagtccacag aaaaccttcc ctcctggccc acccaggtcg cctggtgaaa tcagaagaga cagtcatcct gcagtgttgg tcagatgtca tgtttgaaca cttccttctg cacagagagg ggatgtttaa cgacactttg cgcctcattg gagaacacca tgatggggtc tccaaggcca acttctccat cagtcgcatg acgcaagacc tggcagggac ctacagatgc tacggttctg ttactcactc cccctatcag gtgtcagctc ccagtgaccc tctggacatc gtgatcatag gtctatatga gaaaccttct ctctcagccc agctgggccc cacggttctg gcaggagaga atgtgacctt gtcctgcagc tcccggagct cctatgacat gtaccatcta tccagggaag gggaggccca tgaacgtagg ctccctgcag ggcccaaggt caacggaaca ttccaggctg actttcctct gggccctgcc acccacggag ggacctacag atgcttcggc tctttccatg actctccata cgagtggtca aagtcaagtg acccactgct tgtttctgtc acaggaaacc cttcaaatag ttggccttca cccactgaac caagctccaa aaccgagagg atgtttcacc acgttggcca agcttgtctg aaactcccaa cctcaagtga tccgaccgtc tcagcatgcc aaagtaaccc ccgacacctg cacattctga ttgggacctc agtggtcatc atcctcttca tcctcctctt ctttctcctt catcgctggt gctccaacaa aaaaaatgct gcggtaatgg accaagagtc tgcaggaaac agaacagcga atagcgagga ctctgatgaa caagaccctc aggaggtgac atacacacag ttgaatcact gcgttttcac acagagaaaa atcactcgcc cttctcagag gcccaagaca cccccaacag atatcatcgt gtacacggaa cttccaaatg ctgagtccag atccaaagtt gtctcctgcc catga. It is sometimes possible for the material contained within the vial of "KIR2DL1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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