KCNN4 cdna clone
KCNN4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: plasma membrane; vesicle; voltage-gated potassium channel complex
Molecular Function: calcium-activated potassium channel activity; potassium channel activity; protein binding; protein phosphatase binding
Biological Process: calcium ion transport; defense response; positive regulation of T cell receptor signaling pathway; potassium ion transport; stabilization of membrane potential
Disease: Dehydrated Hereditary Stomatocytosis 2
Research Articles on KCNN4
Similar Products
Product Notes
The KCNN4 kcnn4 (Catalog #AAA1276459) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggcgggg atctggtgct tggcctgggg gccttgagac gccgaaagcg cttgctggag caggagaagt ctctggccgg ctgggcactg gtgctggcag gaactggcat tggactcatg gtgctgcatg cagagatgct gtggttcggg gggtgctcgt gggcgctcta cctgttcctg gttaaatgca cgatcagcat ttccaccttc ttactcctct gcctcatcgt ggcctttcat gccaaagagg tccagctgtt catgaccgac aacgggctgc gggactggcg cgtggcgctg accgggcggc aggcggcgca gatcgtgctg gagctggtgg tgtgtgggct gcacccggcg cccgtgcggg gcccgccgtg cgtgcaggat ttaggggcgc cgctgacctc cccgcagccc tggccgggat tcctgggcca aggggaagcg ctgctgtccc tggccatgct gctgcgtctc tacctggtgc cccgcgccgt gctcctgcgc agcggcgtcc tgctcaacgc ttcctaccgc agcatcggcg ctctcaatca agtccgcttc cgccactggt tcgtggccaa gctttacatg aacacgcacc ctggccgcct gctgctcggc ctcacgcttg gcctctggct gaccaccgcc tgggtgctgt ccgtggccga gaggcaggct gttaatgcca ctgggcacct ttcagacaca ctttggctga tccccatcac attcctgacc atcggctatg gtgacgtggt gccgggcacc atgtggggca agatcgtctg cctgtgcact ggagtcatgg gtgtctgctg cacagccctg ctggtggccg tggtggcccg gaagctggag tttaacaagg cagagaagca cgtgcacaac ttcatgatgg atatccagta taccaaagag atgaaggagt ccgctgcccg agtgctacaa gaagcctgga tgttctacaa acatactcgc aggaaggagt ctcatgctgc ccgcaggcat cagcgcaagc tgctggccgc catcaacgcg ttccgccagg tgcggctgaa acaccggaag ctccgggaac aagtgaactc catggtggac atctccaaga tgcacatgat cctgtatgac ctgcagcaga atctgagcag ctcacaccgg gccctggaga aacagattga cacgctggcg gggaagctgg atgccctgac tgagctgctt agcactgccc tggggccgag gcagcttcca gaacccagcc agcagtccaa gtag. It is sometimes possible for the material contained within the vial of "KCNN4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
