KCNJ10 cdna clone
KCNJ10 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
Uniprot Description
Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, potassium
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ATP-activated inward rectifier potassium channel activity; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding
Biological Process: potassium ion import; potassium ion transport
Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Research Articles on KCNJ10
Similar Products
Product Notes
The KCNJ10 kcnj10 (Catalog #AAA1268990) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACGTCAG TTGCCAAGGT GTATTACAGT CAGACCACTC AGACAGAAAG CCGGCCCCTA ATGGGCCCAG GGATACGACG GCGGAGAGTC CTGACAAAAG ATGGTCGCAG CAACGTGAGA ATGGAGCACA TTGCCGACAA GCGCTTCCTC TACCTCAAGG ACCTGTGGAC AACCTTCATT GACATGCAGT GGCGCTACAA GCTTCTGCTC TTCTCTGCGA CCTTTGCAGG CACATGGTTC CTCTTTGGCG TGGTGTGGTA TCTGGTAGCT GTGGCACATG GGGACCTGCT GGAGCTGGAC CCCCCGGCCA ACCACACCCC CTGTGTGGTA CAGGTGCACA CACTCACTGG AGCCTTCCTC TTCTCCCTTG AATCCCAAAC CACCATTGGC TATGGCTTCC GCTACATCAG TGAGGAATGT CCACTGGCCA TTGTGCTTCT TATTGCCCAG CTGGTGCTCA CCACCATCCT GGAAATCTTC ATCACAGGTA CCTTCCTGGC GAAGATTGCC CGGCCCAAGA AGCGGGCTGA GACCATTCGT TTCAGCCAGC ATGCAGTTGT GGCCTCCCAC AATGGCAAGC CCTGCCTCAT GATCCGAGTT GCCAATATGC GCAAAAGCCT CCTCATTGGC TGCCAGGTGA CAGGAAAACT GCTTCAGACC CACCAAACCA AGGAAGGGGA GAACATCCGG CTCAACCAGG TCAATGTGAC TTTCCAAGTA GACACAGCCT CTGACAGCCC CTTCCTTATT CTACCCCTTA CCTTCTATCA TGTGGTAGAT GAGACCAGTC CCTTGAAAGA TCTCCCTCTT CGCAGTGGTG AGGGTGACTT TGAGCTGGTG CTGATCCTAA GTGGGACAGT GGAGTCCACC AGTGCCACCT GTCAGGTGCG CACTTCCTAC CTGCCAGAGG AGATCCTTTG GGGCTACGAG TTCACACCTG CCATCTCACT GTCAGCCAGT GGTAAATACA TAGCTGACTT TAGCCTTTTT GACCAAGTTG TGAAAGTGGC CTCTCCTAGT GGCCTCCGTG ACAGCACTGT ACGCTACGGA GACCCTGAAA AGCTCAAGTT GGAGGAGTCA TTAAGGGAGC AAGCTGAGAA GGAGGGCAGT GCCCTTAGTG TGCGCATCAG CAATGTCTGA. It is sometimes possible for the material contained within the vial of "KCNJ10, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
