ITGB3 cdna clone
ITGB3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Uniprot Description
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex
Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding
Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing
Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To
Research Articles on ITGB3
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Product Notes
The ITGB3 itgb3 (Catalog #AAA1275023) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCGAGCGC GGCCGCGGCC CCGGCCGCTC TGGGCGACTG TGCTGGCGCT GGGGGCGCTG GCGGGCGTTG GCGTAGGAGG GCCCAACATC TGTACCACGC GAGGTGTGAG CTCCTGCCAG CAGTGCCTGG CTGTGAGCCC CATGTGTGCC TGGTGCTCTG ATGAGGCCCT GCCTCTGGGC TCACCTCGCT GTGACCTGAA GGAGAATCTG CTGAAGGATA ACTGTGCCCC AGAATCCATC GAGTTCCCAG TGAGTGAGGC CCGAGTACTA GAGGACAGGC CCCTCAGCGA CAAGGGCTCT GGAGACAGCT CCCAGGTCAC TCAAGTCAGT CCCCAGAGGA TTGCACTCCG GCTCCGGCCA GATGATTCGA AGAATTTCTC CATCCAAGTG CGGCAGGTGG AGGATTACCC TGTGGACATC TACTACTTGA TGGACCTGTC TTACTCCATG AAGGATGATC TGTGGAGCAT CCAGAACCTG GGTACCAAGC TGGCCACCCA GATGCGAAAG CTCACCAGTA ACCTGCGGAT TGGCTTCGGG GCATTTGTGG ACAAGCCTGT GTCACCATAC ATGTATATCT CCCCACCAGA GGCCCTCGAA AACCCCTGCT ATGATATGAA GACCACCTGC TTGCCCATGT TTGGCTACAA ACACGTGCTG ACGCTAACTG ACCAGGTGAC CCGCTTCAAT GAGGAAGTGA AGAAGCAGAG TGTGTCACGG AACCGAGATG CCCCAGAGGG TGGCTTTGAT GCCATCATGC AGGCTACAGT CTGTGATGAA AAGATTGGCT GGAGGAATGA TGCATCCCAC TTGCTGGTGT TTACCACTGA TGCCAAGACT CATATAGCAT TGGACGGAAG GCTGGCAGGC ATTGTCCAGC CTAATGACGG GCAGTGTCAT GTTGGTAGTG ACAATCATTA CTCTGCCTCC ACTACCATGG ATTATCCCTC TTTGGGGCTG ATGACTGAGA AGCTATCCCA GAAAAACATC AATTTGATCT TTGCAGTGAC TGAAAATGTA GTCAATCTCT ATCAGAACTA TAGTGAGCTC ATCCCAGGGA CCACAGTTGG GGTTCTGTCC ATGGATTCCA GCAATGTCCT CCAGCTCATT GTTGATGCTT ATGGGAAAAT CCGTTCTAAA GTAGAGCTGG AAGTGCGTGA CCTCCCTGAA GAGTTGTCTC TATCCTTCAA TGCCACCTGC CTCAACAATG AGGTCATCCC TGGCCTCAAG TCTTGTATGG GACTCAAGAT TGGAGACACG GTGAGCTTCA GCATTGAGGC CAAGGTGCGA GGCTGTCCCC AGGAGAAGGA GAAGTCCTTT ACCATAAAGC CCGTGGGCTT CAAGGACAGC CTGATCGTCC AGGTCACCTT TGATTGTGAC TGTGCCTGCC AGGCCCAAGC TGAACCTAAT AGCCATCGCT GCAACAATGG CAATGGGACC TTTGAGTGTG GGGTATGCCG TTGTGGGCCT GGCTGGCTGG GATCCCAGTG TGAGTGCTCA GAGGAGGACT ATCGCCCTTC CCAGCAGGAC GAATGCAGCC CCCGGGAGGG TCAGCCCGTC TGCAGCCAGC GGGGCGAGTG CCTCTGTGGT CAATGTGTCT GCCACAGCAG TGACTTTGGC AAGATCACGG GCAAGTACTG CGAGTGTGAC GACTTCTCCT GTGTCCGCTA CAAGGGGGAG ATGTGCTCAG GCCATGGCCA GTGCAGCTGT GGGGACTGCC TGTGTGACTC CGACTGGACC GGCTACTACT GCAACTGTAC CACGCGTACT GACACCTGCA TGTCCAGCAA TGGGCTGCTG TGCAGCGGCC GCGGCAAGTG TGAATGTGGC AGCTGTGTCT GTATCCAGCC GGGCTCCTAT GGGGACACCT GTGAGAAGTG CCCCACCTGC CCAGATGCCT GCACCTTTAA GAAAGAATGT GTGGAGTGTA AGAAGTTTGA CCGGGGAGCC CTACATGACG AAAATACCTG CAACCGTTAC TGCCGTGACG AGATTGAGTC AGTGAAAGAG CTTAAGGACA CTGGCAAGGA TGCAGTGAAT TGTACCTATA AGAATGAGGA TGACTGTGTC GTCAGATTCC AGTACTATGA AGATTCTAGT GGAAAGTCCA TCCTGTATGT GGTAGAAGAG CCAGAGTGTC CCAAGGGCCC TGACATCCTG GTGGTCCTGC TCTCAGTGAT GGGGGCCATT CTGCTCATTG GCCTTGCCGC CCTGCTCATC TGGAAACTCC TCATCACCAT CCACGACCGA AAAGAATTCG CTAAATTTGA GGAAGAACGC GCCAGAGCAA AATGGGACAC AGCCAACAAC CCACTGTATA AAGAGGCCAC GTCTACCTTC ACCAATATCA CGTACCGGGG CACTTAA. It is sometimes possible for the material contained within the vial of "ITGB3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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