ITGAE cdna clone
ITGAE cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Uniprot Description
ITGAE: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Belongs to the integrin alpha chain family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: plasma membrane
Biological Process: extracellular matrix organization and biogenesis
Research Articles on ITGAE
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Product Notes
The ITGAE itgae (Catalog #AAA1267252) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGTGGCTCT TCCACACTCT GCTCTGCATA GCCAGCCTGG CCCTGCTGGC CGCTTTCAAT GTGGATGTGG CCCGGCCCTG GCTCACGCCC AAGGGAGGTG CCCCTTTCGT GCTCAGCTCC CTTCTGCACC AAGACCCCAG CACCAACCAG ACCTGGCTCC TGGTCACCAG CCCCAGAACC AAGAGGACAC CAGGGCCCCT CCATCGATGT TCCCTTGTCC AGGATGAAAT CCTTTGCCAT CCTGTAGAGC ATGTCCCCAT CCCCAAGGGG AGGCACCGGG GAGTGACCGT TGTCCGGAGC CACCACGGTG TTTTGATATG CATTCAAGTG CTGGTCCGGC GGCCTCACAG CCTCAGCTCA GAACTCACAG GCACCTGTAG CCTCCTGGGC CCTGACCTCC GTCCCCAGGC TCAGGCCAAC TTCTTCGACC TTGAAAATCT CCTGGATCCA GATGCACGTG TGGACACTGG AGACTGCTAC AGCAACAAAG AAGGCGGTGG AGAAGACGAT GTGAACACAG CCAGGCAGCG CCGGGCTCTG GAGAAGGAGG AGGAGGAAGA CAAGGAGGAG GAGGAAGACG AGGAGGAGGA GGAAGCTGGC ACCGAGATTG CCATCATCCT GGATGGCTCA GGAAGCATTG ATCCCCCAGA CTTTCAGAGA GCCAAAGACT TCATCTCCAA CATGATGAGG AACTTCTATG AAAAGTGTTT TGAGTGCAAC TTTGCCTTGG TGCAGTATGG AGGAGTGATC CAGACTGAGT TTGACCTTCG GGACAGCCAG GATGTGATGG CCTCCCTCGC CAGAGTCCAG AACATCACTC AAGTGGGGAG TGTCACCAAG ACTGCCTCAG CCATGCAACA CGTCTTAGAC AGCATCTTCA CCTCAAGCCA CGGCTCCAGG AGAAAGGCAT CCAAGGTCAT GGTGGTGCTC ACCGATGGTG GCATATTCGA GGACCCCCTC AACCTTACGA CAGTCATCAA CTCCCCCAAA ATGCAGGGTG TTGAGCGCTT TGCCATTGGG GTGGGAGAAG AATTTAAGAG TGCTAGGACT GCGAGGGAAC TGAACCTGAT CGCCTCAGAC CCGGATGAGA CCCATGCTTT CAAGGTGACC AACTACATGG CGCTGGATGG GCTGCTGAGC AAACTGCGGT ACAACATCAT CAGCATGGAA GGCACGGTTG GAGACGCCCT TCACTACCAG CTGGCACAGA TTGGCTTCAG TGCTCAGATC CTGGATGAGC GGCAGGTGCT GCTCGGCGCC GTCGGGGCCT TTGACTGGTC CGGAGGGGCG TTGCTCTACG ACACACGCAG CCGCCGGGGC CGCTTCCTGA ACCAGACAGC GGCGGCGGCG GCAGACGCGG AGGCTGCGCA GTACAGCTAC CTGGGTTACG CTGTGGCCGT GCTGCACAAG ACCTGCAGCC TCTCCTACGT CGCGGGGGCT CCACAGTACA AACATCATGG GGCCGTGTTT GAGCTCCAGA AGGAGGGCAG AGAGGCCAGC TTCCTGCCAG TGCTGGAGGG AGAGCAGATG GGGTCCTATT TTGGCTCTGA GCTGTGCCCT GTGGACATTG ACATGGATGG AAGCACGGAC TTCTTGCTGG TGGCTGCTCC ATTTTACCAC GTTCATGGAG AAGAAGGCAG AGTCTACGTG TACCGTCTCA GCGAGCAGGA TGGTTCTTTC TCCTTGGCAC GCATACTGAG TGGGCACCCC GGGTTCACCA ATGCCCGCTT TGGCTTTGCC ATGGCGGCTA TGGGGGATCT CAGTCAGGAT AAGCTCACAG ATGTGGCCAT CGGGGCCCCC CTGGAAGGTT TTGGGGCAGA TGATGGTGCC AGCTTCGGCA GTGTGTATAT CTACAATGGA CACTGGGACG GCCTCTCCGC CAGCCCCTCG CAGCGGATCA GAGCCTCCAC GGTGGCCCCA GGACTCCAGT ACTTCGGCAT GTCCATGGCT GGTGGCTTTG ATATTAGTGG CGACGGCCTT GCCGACATCA CCGTGGGCAC TCTGGGCCAG GCGGTTGTGT TCCGCTCCCG GCCTGTGGTT CGCCTGAAGG TCTCCATGGC CTTCACCCCC AGCGCACTGC CCATCGGCTT CAACGGCGTC GTGAATGTCC GTTTATGTTT TGAAATCAGC TCTGTAACCA CAGCCTCTGA GTCAGGCCTC CGTGAGGCAC TTCTCAACTT CACGCTGGAT GTGGATGTGG GGAAGCAGAG GAGACGGCTG CAGTGTTCAG ACGTAAGAAG CTGTCTGGGC TGCCTGAGGG AGTGGAGCAG CGGATCCCAG CTTTGTGAGG ACCTCCTGCT CATGCCCACA GAGGGAGAGC TCTGTGAGGA GGACTGCTTC TCCAATGCCA GTGTCAAAGT CAGCTACCAG CTCCAGACCC CTGAGGGACA GACGGACCAT CCCCAGCCCA TCCTGGACCG CTACACTGAG CCCTTTGCCA TCTTCCAGCT GCCCTATGAG AAGGCCTGCA AGAATAAGCT GTTTTGTGTC GCAGAATTAC AGTTGGCCAC CACCGTCTCT CAGCAGGAGT TGGTGGTGGG TCTCACAAAG GAGCTGACCC TGAACATTAA CCTAACTAAC TCCGGGGAAG ATTCCTACAT GACAAGCATG GCCTTGAATT ACCCCAGAAA CCTGCAGTTG AAGAGGATGC AAAAGCCTCC CTCTCCAAAC ATTCAGTGTG ATGACCCTCA GCCGGTTGCT TCTGTCCTGA TCATGAACTG CAGGATTGGT CACCCCGTCC TCAAGAGGTC ATCTGCTCAT GTTTCAGTCG TTTGGCAGCT AGAGGAGAAT GCCTTTCCAA ACAGGACAGC AGACATCACT GTGACTGTCA CCAATTCCAA TGAAAGACGG TCTTTGGCCA ACGAGACCCA CACCCTTCAA TTCAGGCATG GCTTCGTTGC AGTTCTGTCC AAACCATCCA TAATGTACGT GAACACAGGC CAGGGGCTTT CTCACCACAA AGAATTCCTC TTCCATGTAC ATGGGGAGAA CCTCTTTGGA GCAGAATACC AGTTGCAAAT TTGCGTCCCA ACCAAATTAC GAGGTCTCCA GGTTGCAGCA GTGAAGAAGC TGACGAGGAC TCAGGCCTCC ACGGTGTGCA CCTGGAGTCA GGAGCGCGCT TGTGCGTACA GTTCGGTTCA GCATGTGGAA GAATGGCATT CAGTGAGCTG TGTCATCGCT TCAGATAAAG AAAATGTCAC CGTGGCTGCA GAGATCTCCT GGGATCACTC TGAGGAGTTA CTAAAAGATG TAACTGAACT GCAGATCCTT GGTGAAATAT CTTTCAACAA ATCTCTATAT GAGGGACTGA ATGCAGAGAA CCACAGAACT AAGATCACTG TCGTCTTCCT GAAAGATGAG AAGTACCATT CTTTGCCTAT CATCATTAAA GGCAGCGTTG GTGGACTTCT GGTGTTGATC GTGATTCTGG TCATCCTGTT CAAGTGTGGC TTTTTTAAAA GAAAATATCA ACAACTGAAC TTGGAGAGCA TCAGGAAGGC CCAGCTGAAA TCAGAGAATC TGCTCGAAGA AGAGAATTAG. It is sometimes possible for the material contained within the vial of "ITGAE, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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