IL10RA cdna clone
IL10RA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Uniprot Description
IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: integral to membrane
Molecular Function: protein binding; receptor activity; signal transducer activity
Disease: Inflammatory Bowel Disease 28, Autosomal Recessive
Research Articles on IL10RA
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Product Notes
The IL10RA il10ra (Catalog #AAA1267945) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctgccgt gcctcgtagt gctgctggcg gcgctcctca gcctccgtct tggctcagac gctcatggga cagagctgcc cagccctccg tctgtgtggt ttgaagcaga atttttccac cacatcctcc actggacacc catcccaaat cagtctgaaa gtacctgcta tgaagtggca ctcctgaggt atggaataga gtcctggaac tccatctcca actgtagcca gaccctgtcc tatgacctta ccgcagtgac cttggacctg taccacagca atggctaccg ggccagagtg cgggctgtgg acggcagccg gcactccaac tggaccgtca ccaacacccg cttctctgtg gatgaagtga ctctgacagt tggcagtgtg aacctagaga tccacaatgg cttcatcctc gggaagattc agctacccag gcccaagatg gcccccgcaa atgacacata tgaaagcatc ttcagtcact tccgagagta tgagattgcc attcgcaagg tgccgggaaa cttcacgttc acacacaaga aagtaaaaca tgaaaacttc agcctcctaa cctctggaga agtgggagag ttctgtgtcc aggtgaaacc atctgtcgct tcccgaagta acaaggggat gtggtctaaa gaggagtgca tctccctcac caggcagtat ttcaccgtga ccaacgtcat catcttcttt gcctttgtcc tgctgctctc cggagccctc gcctactgcc tggccctcca gctgtatgtg cggcgccgaa agaagctacc cagtgtcctg ctcttcaaga agcccagccc cttcatcttc atcagccagc gtccctcccc agagacccaa gacaccatcc acccgcttga tgaggaggcc tttttgaagg tgtccccaga gctgaagaac ttggacctgc acggcagcac agacagtggc tttggcagca ccaagccatc cctgcagact gaagagcccc agttcctcct ccctgaccct cacccccagg ctgacagaac gctgggaaac ggggagcccc ctgtgctggg ggacagctgc agtagtggca gcagcaatag cacagacagc gggatctgcc tgcaggagcc cagcctgagc cccagcacag ggcccacctg ggagcaacag gtggggagca acagcagggg ccaggatgac agtggcattg acttagttca aaactctgag ggccgggctg gggacacaca gggtggctcg gccttgggcc accacagtcc cccggagcct gaggtgcctg gggaagaaga cccagctgct gtggcattcc agggttacct gaggcagacc agatgtgctg aagagaaggc aaccaagaca ggctgcctgg aggaagaatc gcccttgaca gatggccttg gccccaaatt cgggagatgc ctggttgatg aggcaggctt gcatccacca gccctggcca agggctattt gaaacaggat cctctagaaa tgactctggc ttcctcaggg gccccaacgg gacagtggaa ccagcccact gaggaatggt cactcctggc cttgagcagc tgcagtgacc tgggaatatc tgactggagc tttgcccatg accttgcccc tctaggctgt gtggcagccc caggtggtct cctgggcagc tttaactcag acctggtcac cctgcccctc atctctagcc tgcagtcaag tgagtga. It is sometimes possible for the material contained within the vial of "IL10RA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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