ID1 cdna clone

ID1

Cat. Num. AAA200592

• Gene Names: ID1; ID; bHLHb24
• Synonyms: ID1; bHLHb24; ID; ID1 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGAAAGTCG CCAGTGGCAG CACCGCCACC GCCGCCGCGG GCCCCAGCTG CGCGCTGAAG GCCGGCAAGA CAGCGAGCGG TGCGGGCGAG GTGGTGCGCT GTCTGTCTGA GCAGAGCGTG GCCATCTCGC GCTGCGCCGG GGGCGCCGGG GCGCGCCTGC CTGCCCTGCT GGACGAGCAG CAGGTAAACG TGCTGCTCTA CGACATGAAC GGCTGTTACT CACGCCTCAA GGAGCTGGTG CCCACCCTGC CCCAGAACCG CAAGGTGAGC AAGGTGGAGA TTCTCCAGCA CGTCATCGAC TACATCAGGG ACCTTCAGTT GGAGCTGAAC TCGGAATCCG AAGTTGGAAC CCCCGGGGGC CGAGGGCTGC CGGTCCGGGC TCCGCTCAGC ACCCTCAACG GCGAGATCAG CGCCCTGACG GCCGAGGCGG CATGCGTTCC TGCGGACGAT CGCATCTTGT GTCGCTGA; ; Translation Sequence: MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG RGLPVRAPLS TLNGEISALT AEAACVPADD RILCR
• Sequence Length: 155

• Species: Human
• Chromosome Location: 20q11
• OMIM Reference Number: 600349
• cDNA Size: 468bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for ID1 cdna clone

ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation.

Product Categories/Family for ID1 cdna clone

Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 31317299
• NCBI GeneID: 3397
• NCBI Accession #: NP_002156.2
• NCBI GenBank Nucleotide #: NM_002165.3
• UniProt Accession #: P41134
• NCBI Official Full Name: DNA-binding protein inhibitor ID-1 isoform a
• NCBI Official Synonym Full Names: inhibitor of DNA binding 1, HLH protein
• NCBI Official Symbol: ID1
• NCBI Official Synonym Symbols: ID; bHLHb24
• NCBI Protein Information: DNA-binding protein inhibitor ID-1
• UniProt Protein Name: DNA-binding protein inhibitor ID-1
• Protein Family: DNA-binding protein inhibitor
• UniProt Gene Name: ID1
• UniProt Synonym Gene Names: BHLHB24; ID; bHLHb24
• UniProt Entry Name: ID1_HUMAN

NCBI Description

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: nucleoplasm; Golgi apparatus; nucleus

Molecular Function: protein dimerization activity; protein binding; transcription factor activity

Biological Process: circadian rhythm; collagen metabolic process; blood vessel endothelial cell migration; transcription, DNA-dependent; protein destabilization; heart development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; BMP signaling pathway; response to antibiotic; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; blood vessel morphogenesis; negative regulation of osteoblast differentiation; endothelial cell morphogenesis; angiogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis