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HLA-DOA cdna clone
HLA-DOA cDNA Clone
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NCBI and Uniprot Product Information
NCBI Description
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
Uniprot Description
HLA-DOA: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: lysosomal membrane; MHC class II protein complex; plasma membrane
Molecular Function: MHC class II receptor activity; protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of antigen processing and presentation of peptide antigen via MHC class II
Research Articles on HLA-DOA
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Product Notes
The HLA-DOA hla-doa (Catalog #AAA1267305) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCCTCA GAGCAGGGCT GGTCCTGGGG TTCCACACCC TGATGACCCT CCTGAGCCCG CAGGAGGCAG GGGCCACCAA GGCTGACCAC ATGGGCTCCT ACGGACCCGC CTTCTACCAG TCTTACGGCG CCTCGGGCCA GTTCACCCAT GAATTTGATG AGGAACAGCT GTTCTCTGTG GACCTGAAGA AAAGCGAGGC CGTGTGGCGT CTGCCTGAGT TTGGCGACTT TGCCCGCTTT GACCCGCAGG GCGGGCTGGC CGGCATCGCC GCAATCAAAG CCCATCTGGA CATCCTGGTG GAGCGCTCCA ACCGCAGCAG AGCCATCAAC GTGCCTCCAC GGGTGACCGT GCTCCCCAAA TCTCGGGTGG AGCTGGGCCA GCCCAACATC CTCATCTGCA TCGTGGACAA CATCTTCCCC CCTGTGATCA ATATCACCTG GCTGCGCAAC GGCCAAACTG TCACTGAGGG AGTGGCCCAG ACCAGCTTCT ATTCCCAGCC TGACCATTTG TTCCGCAAGT TCCACTACCT GCCCTTCGTG CCCTCAGCCG AGGACGTCTA TGACTGCCAG GTGGAGCACT GGGGCCTGGA TGCGCCACTC CTCAGGCATT GGGAGCTCCA GGTGCCTATT CCACCACCAG ATGCCATGGA GACCCTGGTC TGTGCCCTGG GCCTGGCCAT CGGCCTGGTG GGCTTCCTCG TGGGCACCGT CCTCATCATC ATGGGCACAT ATGTGTCCAG TGTCCCCAGG TAA. It is sometimes possible for the material contained within the vial of "HLA-DOA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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